Cara (10mg) 30 Tablets

Leflunomide, a medication primarily used in the treatment of rheumatoid arthritis, exerts its therapeutic effects through the inhibition of dihydroorotate dehydrogenase (DHODH), an enzyme crucial for the de novo synthesis of pyrimidines. By blocking DHODH, leflunomide impedes the production of pyrimidine nucleotides, which are essential for the rapid proliferation of lymphocytes, particularly activated T-cells. This mechanism contributes to the reduction of inflammation and the modulation of the immune response, making leflunomide an effective agent in managing autoimmune conditions like rheumatoid arthritis.

Leflunomide 10mg

Immunosuppressant, DMARD (disease-modifying antirheumatic drug).

Tablet

The following are the uses of Leflunomide 10mg Tablet:

• Used for treating rheumatoid arthritis, providing relief from joint pain and inflammation.
• Used to slow down joint damage and improve physical function in rheumatoid arthritis patients.
• Used to manage symptoms and prevent disease progression in active rheumatoid arthritis.
• Used for its immunosuppressive properties, helping to control autoimmune responses.
• Used as an alternative therapy for patients intolerant to other rheumatoid arthritis treatments.
• Used in combination with other medications for comprehensive rheumatoid arthritis management.
• Used to reduce morning stiffness and improve overall quality of life in rheumatoid arthritis sufferers.

Follow these dosage instructions:

• Adult Dosage

For patients who are at a low risk for liver disease, start with 100mg once daily for 3 days, then 20mg once daily.

• Child Dosage

The dosage for the child is strictly recommended by the doctor.

In the case of an overdose of Leflunomide 10mg Tablets, immediate medical intervention is necessary. Symptoms may include severe diarrhea, nausea, and a significant decrease in white blood cell count, potentially leading to life-threatening infections. It is crucial to seek emergency care promptly, as timely treatment can mitigate the risks associated with Leflunomide overdose. Patients should be closely monitored, and appropriate supportive measures should be implemented to manage any adverse effects and prevent further complications.

In the case of a missed dose of Leflunomide 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare professional for advice on how to safely resume your medication without affecting its effectiveness.

To take Leflunomide 10mg Tablets, swallow the tablet whole with a full glass of water, preferably at the same time each day, as directed by your healthcare professional, and ensure you read and understand the medication guide provided with the medication.

Following are the conditions/situations when Leflunomide 10mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Leflunomide or any of its components.
• Contraindicated in pregnant women or women who are planning to become pregnant.
• Not suitable for breastfeeding mothers.
• Should not be used in individuals with severe liver or kidney disease.
• Avoid if you have a weakened immune system or suffer from severe infections.
• Not recommended for individuals with severe blood disorders or bone marrow suppression.
• Contraindicated in patients with severe gastrointestinal disorders, such as ulcerative colitis or Crohn's disease.
• Should not be used if you have uncontrolled high blood pressure.
• Avoid if you have a history of severe skin reactions or sensitivity to sunlight.

The side effects of Leflunomide 10mg Tablet may include:

• Diarrhea
• Nausea and vomiting
• Hair loss
• Skin rash or itching
• Increased blood pressure
• Liver problems (elevated liver enzymes)
• Respiratory tract infections
• Fatigue and weakness

Following are the precautions and warnings for Leflunomide 10mg Tablet:

• Leflunomide may cause liver problems, and regular monitoring of liver function is necessary. Discontinue use if liver enzymes rise significantly.
• Patients with pre-existing liver conditions or a history of liver disease should use this medication with caution and under close medical supervision.
• This medication can cause blood disorders, including bone marrow suppression. Regular blood tests are required to monitor blood cell counts.
• Leflunomide may increase the risk of infection. Patients should report any signs of infection to their doctor immediately.
• It is not recommended for use during pregnancy as it may cause harm to the fetus. Effective contraception is essential while taking this medication.
• Breastfeeding is not advisable while using Leflunomide, as it can pass into breast milk and harm nursing infants.
• This medication may cause severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Discontinue use and seek medical attention if any skin rashes or severe skin reactions occur.
• Leflunomide can increase blood pressure, so regular monitoring is advised, especially in patients with hypertension.

Following are the drug interactions for Leflunomide 10mg Tablet:

• Concomitant use with methotrexate can increase the risk of liver toxicity and bone marrow suppression. Close monitoring is essential.
• Avoid combining with teriflunomide due to similar mechanisms of action, as it may lead to additive immunosuppression and increased side effects.
• Leflunomide may reduce the effectiveness of live vaccines, so it's recommended to complete vaccinations before starting treatment.
• The risk of bleeding may be increased when taken with anticoagulants like warfarin, requiring close monitoring of coagulation parameters.
• Use with caution alongside nonsteroidal anti-inflammatory drugs (NSAIDs), as this combination may further enhance the risk of gastrointestinal side effects and bleeding.
• Leflunomide can potentially decrease the effectiveness of some hormonal contraceptives, so alternative birth control methods are advised.
• It may interact with drugs that are substrates of CYP2C19, affecting the metabolism of these medications.

Following are the food interactions for Leflunomide 10mg Tablet:

• Avoid grapefruit and grapefruit juice as they may alter the drug's metabolism, leading to increased Leflunomide levels in the body.
• Alcohol consumption should be limited as it can increase the risk of liver damage and other side effects.
• Avoid fatty meals as high-fat foods can decrease the absorption of Leflunomide, reducing its effectiveness.
• Vitamin A supplements should be used with caution as Leflunomide may increase Vitamin A toxicity.
• Avoid black or green tea as they contain polyphenols that can interfere with Leflunomide's absorption.
• Do not consume cranberry juice as it may decrease the elimination of Leflunomide, leading to higher levels in the body.
• Consult a doctor if you regularly consume large amounts of garlic, as it may interact with the medication's blood-thinning effects.
• Always follow medical advice regarding diet restrictions when taking Leflunomide.

Leflunomide 10mg Tablets should be stored in a secure and dry location, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures, such as those found in bathrooms or near heat sources like stoves or radiators, as this can impact its effectiveness. When disposing of Leflunomide, it is important to follow proper procedures; do not flush or pour the medication down the drain. Instead, consult your pharmacist or healthcare professional for safe disposal methods to protect the environment. Keep the tablets out of children's reach to prevent accidental consumption, and always exercise caution when handling and storing this medication.

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Following are the quick tips for Leflunomide 10mg Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily.
• Consume the tablet with a full glass of water to aid in swallowing.
• Leflunomide can be taken with or without food but take it consistently with regards to meals.
• Avoid alcohol consumption while on this medication as it may increase side effects.
• Regular blood tests are necessary to monitor liver function and blood cell counts.
• Inform your doctor of all medications you're taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.