Cefask (400mg) 5 Capsules

Antibiotic, Cephalosporin (Third Generation). This drug exerts its actions by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, and thus causing the inhibition of the third and last stage of bacterial cell wall synthesis. Due to inhibition of the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, cell wall biosynthesis is also inhibited. Eventually bacterial cell lysis occurs due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases). With this mechanism of action this drug fights against various bacterial infections.

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Cephalosporin antibiotic

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Capsule

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Used for:

• Urinary Tract Infections (UTI)

• Chronic Bronchitis

• Tonsillitis (Tonsils)

• Pharyngitis

• Gonorrhea

• Otitis Media

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Dose must be taken according to doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose (For chronic bronchitis, otitis media, gonorrhea, urinary tract infection): 400mg daily divided dose every 12 to 24 hours. Pediatric dose (For Chronic Bronchitis, Otitis media, Pharyngitis, Tonsillitis, Gonorrhea, Urinary tract infection): Children of age 6 months to 12 years, body weight is not more than 45kg; then take 8mg/kg/day in single dose or in divided doses after 12 hours. For 12 years above age: weight is more than 45kg; then take 400mg once.

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Consult your doctor in case of overdose.

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If you miss any dose then take the dose as soon as you remember, but if it's the time for the next dose then do not double the dose.

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Take it orally according to your doctor's instructions. Constitute the suspension according to given instructions with the product.

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Do not use this medicine in case of hypersensitivity to cefixime, any component of the formulation, or other cephalosporins or penicillins.

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Unraveling the side effects lurking behind this product are the following:

• Diarrhea

• Abdominal pain

• Nausea

• Dyspepsia

• Flatulence

• Loose stools

• Anaphylaxis

• Angioedema

• Candidiasis

• Dizziness

• Drug fever

• Eosinophilia

• Erythema

• Facial edema

• Fever

• Headache

• Hepatitis

• Hyperbilirubinemia

• Increased blood urea nitrogen

• Increased serum creatinine

• Increased serum transaminases

• Jaundice

• Leukopenia

• Neutropenia

• Prolonged prothrombin time

• Pruritus

• Pseudomembranous colitis

• Seizure

• Serum sickness-like reaction

• Skin rash

• Stevens-Johnson syndrome

• Thrombocytopenia

• Toxic epidermal necrolysis

• Urticaria

• Vaginitis

• Vomiting

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If dermatologic reactions, Severe cutaneous reactions occur, discontinue the medicine, and institute supportive therapy. Immune-mediated Hemolytic anemia has been reported with the use of this drug. Monitor patients parameters (including hematologic parameters and drug-induced antibody testing when clinically appropriate) during and for 2 to 3 weeks after therapy. Use caution in patients with a history of hypersensitivity to Cefixime; cephalosporins, penicillins, or other beta-lactams, discontinue use if allergic reaction occurs. If renal failure occurs, discontinue and initiate appropriate supportive therapy. Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months post antibiotic treatment with this drug. Cefixime can cross the placenta and can be detected in the amniotic fluid, so caution is required while prescribing such medicine to the pregnant ladies.

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The drug interactions with cefixime include:

• Anticoagulants (e.g., warfarin) – Cefixime may enhance the anticoagulant effect, increasing the risk of bleeding.
• Probenecid – May increase the levels of cefixime by decreasing its renal clearance.
• Live Bacterial Vaccines (e.g., typhoid vaccine) – Cefixime may reduce the effectiveness of live bacterial vaccines.
• Methotrexate – Cefixime may increase methotrexate levels, leading to increased toxicity.
• Other Antibiotics (e.g., aminoglycosides) – May have additive nephrotoxic effects when used concurrently with cefixime.
• Oral Contraceptives – Cefixime may potentially reduce the effectiveness of oral contraceptives.
• Diuretics (e.g., furosemide) – Concurrent use may increase the risk of nephrotoxicity.
• Calcium-containing Products – Cefixime absorption may be reduced if taken with calcium-containing products.
• Antacids – May reduce cefixime absorption if taken simultaneously.

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Food can delay cefixime absorption. You may administer with or without food. Avoid the use of grapefruit with this medication as it may hinder its therapeutic effectiveness.

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Store below 30°C. Protect from sunlight, heat and moisture.

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