Cefazol (1g) 1 Vial Injection

Cefazolin injection, a first-generation cephalosporin antibiotic, exerts its bactericidal effect by disrupting bacterial cell wall synthesis. It specifically targets penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands during cell wall formation. By binding to these PBPs, Cefazolin inhibits the final stages of peptidoglycan synthesis, leading to weakened cell walls and eventual cell lysis. This mechanism is highly effective against a range of susceptible gram-positive and some gram-negative bacteria, making Cefazolin a valuable agent for treating various infections.

Cefazolin

Cephalosporin antibiotic

Injection

The following are the uses of Cefazolin Injection:

• Used for the treatment of bacterial infections such as skin and soft tissue infections, bone and joint infections, and respiratory tract infections.
• Used for preventing surgical site infections in various types of surgeries.
• Used for treating bacterial endocarditis, a heart valve infection.
• Used for managing bacterial sepsis, ensuring effective control of the infection.
• Used for treating urinary tract infections caused by susceptible bacteria.
• Used for controlling bacterial infections in patients with weakened immune systems.
• Used for the management of certain gynecological infections.
• Used for the treatment of bacterial meningitis, an inflammation of the brain's membranes.

In the case of an overdose of Cefazolin Injection, the primary concern is the potential for severe allergic reactions and adverse effects on the kidneys and liver. Symptoms may include nausea, vomiting, diarrhea, and skin rashes. Prompt medical attention is required to manage these symptoms and prevent further complications. Treatment may involve supportive care, monitoring of vital signs, and administering antihistamines or other medications to counteract the effects of the overdose. It is crucial to seek medical assistance immediately to ensure proper management.

In the case of a missed dose of Cefazolin Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your treatment. It is recommended to set reminders or alarms to help you remember to take your medication on time.

To administer Cefazolin Injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and inject the prescribed amount slowly, ensuring the entire dose is delivered, then gently remove the needle and apply light pressure with a sterile gauze pad if needed.

Here are the conditions or situations when Cefazolin Injection should not be administered:

• Avoid if the patient has a confirmed severe allergy to Cefazolin or any other cephalosporin antibiotics.
• Do not use if the patient has a history of severe and immediate hypersensitivity reactions to penicillins.
• Contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with Cefazolin.
• Not recommended for patients with severe renal impairment (unless dialysis is performed).
• Should not be administered to infants below one month of age.
• Avoid if the patient has a history of severe gastrointestinal diseases, especially colitis.
• Not suitable for patients with a history of seizures or other neurological disorders.
• Do not use for patients with a history of severe allergic reactions to multiple allergens.

The side effects of Cefazolin Injection may include:

• Skin rashes or itching
• Diarrhea
• Nausea and vomiting
• Pain or swelling at the injection site
• Headache
• Dizziness
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)
• Kidney problems (increased or decreased urination, blood in urine)

Following are the precautions and warnings for Cefazolin Injection:

• Not suitable for patients with a known hypersensitivity to cefazolin or other cephalosporin antibiotics, as it may cause severe allergic reactions, including anaphylaxis.
• Caution is required in patients with a history of penicillin allergy, as cross-reactivity may occur.
• Use with caution in patients with renal impairment, as dose adjustment may be necessary to prevent drug accumulation and toxicity.
• Prolonged use may lead to superinfection, including Clostridium difficile-associated diarrhea.
• Intravenous administration should be monitored to prevent thrombophlebitis at the injection site.
• Regular kidney function tests should be performed, especially in elderly patients or those with pre-existing renal conditions.
• Cefazolin should be used with caution in patients with gastrointestinal diseases, particularly colitis, due to the risk of antibiotic-associated diarrhea.
• Avoid mixing cefazolin with calcium-containing solutions, such as Ringer’s lactate, to prevent drug incompatibility.
• Complete the full course of treatment as prescribed to prevent bacterial resistance.

Following are the drug interactions for Cefazolin Injection:

• Probenecid can reduce the renal tubular secretion of cefazolin, increasing its serum levels.
• May decrease the effectiveness of oral contraceptives, leading to breakthrough bleeding and potential contraceptive failure.
• Concurrent use with nephrotoxic drugs (e.g., aminoglycosides, colistin) may increase the risk of renal toxicity.
• Cefazolin can affect the results of certain coagulation tests (e.g., prothrombin time) in patients receiving warfarin.
• The risk of bleeding may increase when used with anticoagulants like heparin.
• May reduce the effectiveness of live attenuated vaccines such as measles, mumps, and rubella.
• Cefazolin may reduce the clearance of thiopental, leading to prolonged sedation.

Following are the food interactions for Cefazolin Injection:

• Avoid alcohol consumption during the treatment period as it may increase the risk of liver-related side effects and affect the efficacy of Cefazolin.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Cefazolin, potentially altering its effectiveness.
• High-fat meals may delay the absorption of Cefazolin, so it is advisable to take the medication on an empty stomach or at least 1 hour before or 2 hours after a meal.
• Caffeine-rich foods and beverages might interfere with the absorption of Cefazolin, so it is best to limit their intake during treatment.
• Avoid consuming herbal supplements or alternative medicines without medical advice as some may interact with Cefazolin and affect its therapeutic effect.
• Vitamin K-rich foods like leafy greens may reduce the effectiveness of Cefazolin, so consult your healthcare provider for dietary adjustments if you are on long-term treatment.
• Ensure adequate fluid intake to maintain hydration, especially if experiencing diarrhea as a side effect of Cefazolin.
• There are no specific food restrictions with Cefazolin, but maintaining a balanced diet is essential for overall health and recovery.

Cefazolin Injection should be stored in a cool, controlled environment, preferably between 2°C and 8°C (36°F and 46°F). Protect the injection vials from light and moisture to maintain their integrity. It is crucial not to freeze the solution as it may affect its potency. Always check the expiration date before use and discard any expired or unused vials. Proper disposal of Cefazolin Injection is essential; do not dispose of it by flushing or pouring it down the drain. Contact your healthcare provider or pharmacist for guidance on safe disposal methods to ensure environmental responsibility. Keep this medication out of the sight and reach of children to prevent accidental exposure.

Following are the quick tips for Cefazolin Injection:

• Administer the injection as directed by your healthcare professional, ensuring the prescribed dosage is followed.
• Cefazolin should be injected slowly into the muscle or vein as instructed.
• Before use, visually inspect the solution for any discoloration or particles.
• To minimize discomfort, rotate injection sites for intramuscular injections.
• For intravenous use, ensure the solution is warmed to room temperature before administration.
• Do not mix Cefazolin with other medications unless instructed by your doctor.
• Store the injection as directed, away from direct sunlight and moisture.