Cefrom (1g) 1 Vial Injection

Cefpirome is a fourth-generation cephalosporin antibiotic that exerts its bactericidal effect by inhibiting cell wall synthesis in susceptible bacteria. It achieves this by binding to and inhibiting specific penicillin-binding proteins (PBPs) responsible for cross-linking peptidoglycan strands, an essential component of the bacterial cell wall. This binding interferes with the transpeptidation reaction, leading to weakened cell wall integrity, which ultimately results in cell lysis and death. Cefpirome's mechanism of action is similar to that of other cephalosporins, but its extended spectrum of activity, including against some gram-negative bacteria with resistance to earlier generations, makes it a valuable option for treating a range of infections.

Cefpirome 1000MG

Fourth-generation cephalosporin.

injection

The following are the uses of Cefpirome 1000MG injection:

• Used for treating severe bacterial infections like pneumonia and complicated urinary tract infections.
• Used for hospital-acquired infections requiring potent antibiotics.
• Used for infections caused by susceptible bacteria, including E. coli and Klebsiella.
• Used for surgical prophylaxis to prevent post-operative infections.
• Used for sepsis and other bloodstream infections.
• Used for skin and soft tissue infections, ensuring rapid improvement.
• Used for managing severe intra-abdominal infections.
• Used for empirical therapy before specific pathogens are identified.

In the case of an overdose of Cefpirome 1000MG injection, immediate medical intervention is necessary. Symptoms may include nausea, vomiting, and diarrhea, and in severe cases, seizures and respiratory distress. It is important to seek emergency medical care promptly, as timely treatment can help manage the adverse effects and prevent further complications. Healthcare professionals should be informed about the overdose to ensure appropriate monitoring and supportive care.

In the case of a missed dose of Cefpirome 1000MG injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for guidance, as they may recommend adjusting your dosing schedule or provide specific instructions to ensure you receive the full therapeutic benefit of the medication.

To administer Cefpirome 1000MG injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, inject the entire contents of the vial slowly, and then gently remove the needle while applying pressure with a sterile gauze pad to prevent any leakage.

Following are the conditions when Cefpirome 1000MG injection should not be used:

• Should not be administered to individuals with a confirmed hypersensitivity or severe allergic reaction to Cefpirome or other cephalosporin antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to penicillins, as there may be cross-reactivity.
• Not recommended for patients with severe kidney impairment without adjusting the dosage.
• Should be avoided in patients with a history of seizures or conditions that increase the risk of seizures, as it may lower the seizure threshold.
• Not suitable for patients with severe infections that require treatment with antibiotics with a broader spectrum of activity.
• Must not be used in place of surgical intervention for conditions that require immediate surgical treatment.
• Contraindicated in neonates, especially premature infants, due to the risk of bilirubin encephalopathy.

The possible side effects of Cefpirome 1000MG injection are:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Increased liver enzymes
• Headache
• Dizziness
• Pain or inflammation at the injection site

Following are the precautions and warnings for Cefpirome 1000MG injection:

• This medication should be used with caution in patients with a history of allergic reactions to cephalosporins or other beta-lactam antibiotics.
• Regular monitoring of kidney function is essential, especially in patients with pre-existing kidney disease, as Cefpirome is eliminated primarily through the kidneys.
• Cefpirome may cause neurological side effects; patients should be advised to report any symptoms like seizures, dizziness, or confusion immediately.
• Prolonged use may lead to the overgrowth of non-susceptible bacteria or fungi; regular evaluation is necessary to discontinue treatment if superinfection occurs.
• Elderly patients may be more susceptible to the effects and side effects of this medication, requiring careful monitoring.
• Cefpirome should be used with caution in patients with a history of gastrointestinal diseases, particularly colitis, as it may exacerbate these conditions.
• Patients should be advised to complete the full course of treatment, even if they feel better before the medication is finished, to ensure complete eradication of the infection.

Following are the drug interactions for Cefpirome 1000MG injection:

• Probenecid can decrease the renal tubular secretion of cefpirome, leading to increased plasma concentrations.
• Concomitant use with nephrotoxic drugs (e.g., aminoglycosides, diuretics) may increase the risk of renal toxicity.
• May reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Cefpirome can affect the gut flora, potentially reducing the absorption of oral vitamin K and leading to decreased prothrombin levels.
• Neuromuscular blocking agents, such as vecuronium, may have their effects potentiated by cefpirome.
• Concurrent use with other antibiotics may lead to an increased risk of antibiotic-associated colitis.
• Cefpirome may interfere with certain laboratory tests, such as Coombs' test and glucose testing using glucose oxidase methods.

Following are the food interactions for Cefpirome 1000MG injection:

• Avoid consuming alcohol during and after the treatment, as it may increase the risk of side effects and affect the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the absorption of Cefpirome, potentially leading to reduced effectiveness.
• Dairy products, especially milk, may decrease the absorption of Cefpirome. Avoid consuming large amounts of dairy immediately before or after taking the medication.
• High-fat meals may delay the absorption of Cefpirome, so it is advisable to avoid consuming fatty foods close to medication intake.
• Caffeine-rich foods and beverages may potentially decrease the efficacy of Cefpirome, so consider reducing caffeine intake during treatment.
• Avoid taking herbal supplements or natural remedies without medical advice, as some may interact with Cefpirome and affect its effectiveness.
• Always inform your healthcare provider about your dietary habits to ensure the medication's optimal efficacy and safety.
• Follow the dosage instructions provided by your doctor to ensure the best therapeutic outcome.

Cefpirome 1000MG injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. Maintain a temperature range between 68°F and 77°F (20°C and 25°C) to ensure its stability. Always keep the injection in its original packaging, securely sealed, to prevent contamination. Do not store it in the bathroom or kitchen, as these areas may expose it to heat and humidity. Dispose of any unused or expired cefpirome injection through appropriate medical waste channels; do not discard it in regular trash or pour it down the drain. Responsible disposal helps protect the environment and prevents unauthorized access. Always keep medications out of the sight and reach of children to avoid accidental ingestion.

Following are the quick tips for Cefpirome 1000MG injection:

• Cefpirome is a potent antibiotic, administer as directed by your doctor.
• Ensure the injection is administered by a trained healthcare professional.
• Inform your doctor about any allergies or medical conditions before injection.
• Avoid missing doses; complete the full course as prescribed.
• Store the injection at room temperature, away from direct sunlight.
• Do not reuse needles or syringes; dispose of them safely.
• If you experience any severe side effects, seek immediate medical attention.