Ceftiz (1000mg) 1 Vial Injection

Ceftizoxime, a third-generation cephalosporin antibiotic, exerts its bactericidal effect by inhibiting cell wall synthesis in susceptible bacteria. It specifically targets penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands in the bacterial cell wall. By binding to these PBPs, ceftizoxime disrupts the final stages of cell wall synthesis, leading to the weakening and eventual lysis of the bacterial cell. This antibiotic has a broad spectrum of activity, covering a wide range of Gram-positive and Gram-negative bacteria, including many strains resistant to other beta-lactam antibiotics. The mechanism of action involves ceftizoxime's ability to penetrate the bacterial cell wall and bind to PBPs, ultimately interfering with the structural integrity of the cell wall and resulting in bacterial cell death.

Ceftizoxime 1000mg

Third-generation cephalosporin.

injection

The following are the uses of Ceftizoxime 1000mg injection:

• Used for treating severe bacterial infections such as pneumonia, skin and soft tissue infections, and urinary tract infections.
• Used for coverage against a wide range of bacteria, including E. coli, Klebsiella, and Proteus species.
• Used for surgical prophylaxis to prevent infections during high-risk surgeries.
• Used for treating infections in patients with weakened immune systems or those who cannot take oral antibiotics.
• Used for empirical therapy when the causative bacteria is unknown, providing broad-spectrum coverage.
• Used for managing infections in patients with a history of penicillin allergies, as it is a cephalosporin antibiotic.
• Used for treating hospital-acquired infections, particularly in intensive care units.
• Used for short-term treatment, with dosage and duration determined by the severity of the infection.

In the case of an overdose of Ceftizoxime 1000mg injection, it is crucial to act promptly. Initial symptoms may include nausea, vomiting, and diarrhea. More severe cases can lead to seizures, confusion, and changes in vital signs. Seek medical attention immediately and provide healthcare professionals with details of the overdose, including the estimated amount ingested and the time of ingestion. Prompt treatment can help manage symptoms and prevent potential complications.

In the case of a missed dose of Ceftizoxime 1000mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for the missed one. It is crucial to maintain a consistent medication routine, but if you frequently miss doses, inform your healthcare professional for further guidance on how to manage and adjust the dosing schedule to ensure optimal treatment.

To administer Ceftizoxime 1000mg injection, prepare the medication by drawing the prescribed dose into a syringe, then inject it slowly into a muscle or intravenous line as directed by your healthcare provider, ensuring the injection is given at the recommended dosage and frequency.

Following are the conditions when Ceftizoxime 1000mg injection should not be administered:

• Must not be used in patients with a known allergy to Ceftizoxime or other cephalosporin antibiotics.
• Contraindicated in patients with a history of severe hypersensitivity reactions to penicillins, as cross-reactivity may occur.
• Not suitable for patients with a history of severe or immediate allergic reactions to beta-lactam antibiotics.
• Should not be used in patients with a confirmed diagnosis of infectious mononucleosis, as it is not effective against the causative virus.
• Avoid use in patients with a history of gastrointestinal diseases, especially colitis, as it may exacerbate these conditions.
• Not recommended for patients with a history of seizures or conditions that increase the risk of seizures.
• Discontinue use if signs of anaphylactic reactions or severe skin reactions occur during treatment.
• Exercise caution and avoid use in patients with severe renal impairment, as dosage adjustments are necessary.

The side effects of Ceftizoxime 1000mg injection may include:

• Skin rash or itching
• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Headache
• Dizziness
• Allergic reactions (e.g., hives, itching, difficulty breathing)
• Thrombophlebitis (inflammation of the vein) at the injection site

Following are the precautions and warnings for Ceftizoxime 1000mg injection:

• This medication should not be administered to individuals with a history of severe allergic reactions to penicillin or other beta-lactam antibiotics.
• Patients with a known allergy to cephalosporin antibiotics should use it with caution, as cross-reactivity may occur.
• Ceftizoxime may cause diarrhea, and in rare cases, it can lead to severe diarrhea caused by Clostridium difficile. Discontinue use if severe diarrhea occurs and seek medical attention.
• Prolonged use may result in the overgrowth of non-susceptible organisms, including fungi. Monitor patients for signs of superinfection.
• Ensure proper hydration and urinary output during treatment, especially in patients with kidney impairment.
• Elderly patients may be more susceptible to adverse reactions; renal function should be monitored.
• Safety and efficacy in pregnant and breastfeeding women have not been established. Consult a healthcare professional for advice.
• Discontinue use if any serious adverse reactions occur, such as severe skin reactions, seizures, or signs of pseudomembranous colitis.

Following are the drug interactions for Ceftizoxime 1000mg injection:

• Probenecid can decrease the renal excretion of ceftizoxime, leading to increased serum levels of the antibiotic.
• May reduce the effectiveness of oral contraceptives, so additional contraception is recommended.
• Concurrent use with other nephrotoxic drugs (e.g., aminoglycosides, colistin) may increase the risk of kidney damage.
• Ceftizoxime can affect prothrombin time tests, so monitoring is necessary when used with anticoagulants like warfarin.
• The efficacy of live bacterial vaccines (e.g., oral polio, Salmonella typhi) may be diminished.
• When administered with other beta-lactam antibiotics, there is a potential risk of cross-allergic reactions.
• May reduce the effectiveness of antidiabetic medications, requiring close monitoring of blood glucose levels.

Following are the food interactions for Ceftizoxime 1000mg injection:

• Avoid consuming alcohol during the treatment period as it may increase the risk of side effects and affect the effectiveness of the medication.
• Grapefruit and its juice should be consumed with caution as they may interfere with the medication's metabolism, leading to increased drug levels in the body.
• Dairy products like milk, cheese, and yogurt may reduce the absorption of Ceftizoxime, so it is advisable to separate them by a few hours when taking the medication.
• High-fat meals might delay the absorption of Ceftizoxime, so it is recommended to avoid consuming fatty foods immediately before or after taking the injection.
• Avoid consuming herbal teas or supplements containing St. John's Wort as it may reduce the effectiveness of Ceftizoxime.
• Ensure adequate hydration during the treatment, as proper fluid intake supports the body's overall functioning while on medication.
• Avoid consuming vitamin C supplements or citrus fruits in large quantities, as they may alter the pH of urine and potentially affect the excretion of Ceftizoxime.
• Consult your healthcare provider for specific dietary instructions, especially if you have underlying health conditions that require dietary restrictions.

Ceftizoxime 1000mg injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20°C and 25°C (68°F to 77°F). Protect the injection from direct sunlight, as exposure to light can degrade its potency. Keep the medication in its original packaging, ensuring the vial or ampoule is intact and tightly sealed to maintain sterility. It is crucial to check the expiration date before use and discard any expired or unused portions accordingly. When disposing of the injection, do not flush it down the toilet or pour it into a drain. Instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for appropriate methods to ensure environmental safety. Keep this medication securely stored, out of the reach of children and pets, to prevent accidental exposure.

Following are the quick tips for Ceftizoxime 1000mg injection:

• Ensure the injection is administered by a trained healthcare professional.
• Confirm your medical history and allergies before injection.
• Receive the injection as prescribed, usually 3-4 times daily.
• Stay hydrated and drink plenty of fluids during treatment.
• Report any signs of allergic reaction immediately.
• Avoid missing doses; complete the full course as prescribed.
• Store the injection at room temperature, away from light and moisture.