CEFYL-ESF 125ML COUGH SYRUP

Acefylline Piperazine acts as a bronchodilator by relaxing the smooth muscles in the airways. It works by inhibiting phosphodiesterase enzymes, leading to increased levels of cyclic AMP, which helps relax the bronchial smooth muscles and improves airflow. Diphenhydramine, on the other hand, is an antihistamine that blocks the histamine H1 receptors, providing relief from allergic symptoms.

Acefylline Piperazine 125mg/5ml, Diphenhydramine 8mg/5ml

Bronchodilator, antihistamine.

Suspension

The following are the uses of Acefylline Piperazine 125mg/5ml, Diphenhydramine 8mg/5ml Syrup/Suspension:

• Used for treating respiratory conditions such as chronic bronchitis, emphysema, and asthma, to relax the airways and improve breathing.
• Used for reducing inflammation and mucus production in the airways.
• Used for relieving symptoms like coughing, wheezing, and shortness of breath.
• Used for managing allergic reactions and providing sedation in certain medical procedures.
• Used for its antihistamine properties to alleviate allergy symptoms like sneezing, runny nose, and itchy eyes.
• Used for promoting relaxation and sleep in patients with allergies or respiratory issues.
• Used for its bronchodilator effects, making it easier to breathe and reducing the effort required for respiration.

In the case of an overdose of Acefylline Piperazine 125mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension, symptoms may include nausea, vomiting, rapid heartbeat, confusion, and in severe cases, seizures or loss of consciousness. Prompt medical attention is necessary to manage the overdose effectively. Treatment may involve gastric lavage, activated charcoal administration, and supportive care to address any cardiovascular or neurological complications. It is crucial to act quickly and seek medical assistance.

In the case of a missed dose of Acefylline Piperazine 125mg/5ml, administer the missed dose as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. For Diphenhydramine 8mg/5ml Syrup, if a dose is missed, take it as soon as possible. However, if it is nearly time for the next dose, skip the missed dose and resume the regular dosing frequency. It's important not to double the dose to make up for a missed one.

To administer Acefylline Piperazine 125mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension, shake the bottle well, measure the prescribed dose with an accurate measuring device, and take it orally as directed by your healthcare provider, with or without food, following the recommended dosage instructions.

Following are the conditions when Acefylline Piperazine 125mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension should not be used:

• Not suitable for individuals with a known allergy to Acefylline Piperazine, Diphenhydramine, or any other antihistamines.
• Contraindicated in patients with narrow-angle glaucoma.
• Should not be used in patients with a history of bronchial asthma or other respiratory conditions.
• Not recommended for individuals with a history of seizures or epilepsy.
• Avoid in patients with prostate enlargement or urinary retention issues.
• Should not be used in patients with severe heart disease or cardiovascular conditions.
• Contraindicated during breastfeeding as it may pass into breast milk.
• Not suitable for individuals with a known sensitivity to any of the excipients in the syrup/suspension.

The side effects of Acefylline Piperazine 125mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension may include:

• Nausea and vomiting
• Dry mouth and throat
• Drowsiness or sedation
• Blurred vision or dizziness
• Constipation or diarrhea
• Allergic reactions, such as rash or itching
• Difficulty in urination
• Increased heart rate or palpitations

Following are the precautions and warnings for Acefylline Piperazine 125mg/5ml, Diphenhydramine 8mg/5ml Syrup/Suspension:

• This medication should be used with caution in patients with a history of gastrointestinal ulcers or bleeding, as it may worsen these conditions.
• Patients with heart disease, high blood pressure, or an overactive thyroid should exercise caution, as this medication may affect heart rate and blood pressure.
• It is important to avoid activities requiring mental alertness, such as driving, until the patient's response to the medication is known, as it can cause dizziness and drowsiness.
• Not recommended for use in patients with narrow-angle glaucoma, as it may exacerbate the condition.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as its effects on the fetus and infant are not fully established.
• Elderly patients may be more sensitive to the side effects of this medication, particularly the central nervous system effects.
• Patients with liver or kidney disease should be monitored closely, as dosage adjustments may be necessary due to the potential impact on drug metabolism and excretion.
• Avoid alcohol consumption while taking this medication, as it may intensify the sedative effects and increase the risk of side effects.

Following are the drug interactions for Acefylline Piperazine 125mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension:

• Acefylline may interact with xanthine derivatives like theophylline, potentially increasing their effects and leading to adverse reactions.
• Use with caution alongside other central nervous system (CNS) depressants, including alcohol, as it can enhance sedative effects and impair cognitive function.
• Antihistamines like diphenhydramine can reduce the clearance of Acefylline, leading to increased serum levels and potential toxicity.
• Concomitant use with antidiabetic medications may require dosage adjustments due to the potential hypoglycemic effect of Acefylline.
• Diphenhydramine can intensify the drowsiness caused by other sedatives, opioids, or muscle relaxants, necessitating careful monitoring.
• Monoamine oxidase inhibitors (MAOIs) should be avoided with Diphenhydramine, as it may increase the risk of serious adverse reactions.
• Diphenhydramine may interact with anticholinergic medications, potentially causing increased side effects such as dry mouth, blurred vision, and urinary retention.
• Anticonvulsant medications may require dosage adjustments when used with Diphenhydramine due to its potential to affect seizure thresholds.

Following are the food interactions for Acefylline Piperazine 125mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension:

• Caffeine-containing foods and beverages (coffee, tea, energy drinks) should be limited as they can reduce the sedative effects of Diphenhydramine, potentially making it less effective for sleep or allergy relief.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Diphenhydramine, leading to increased side effects like drowsiness and dizziness.
• Alcohol should be consumed with caution as it can enhance the sedative effects of Diphenhydramine, increasing the risk of dizziness, drowsiness, and impaired coordination.
• Acefylline Piperazine may cause a loss of appetite; ensure you maintain a balanced diet to meet your nutritional needs.
• Spicy and acidic foods should be avoided if the medication causes stomach irritation, as they can aggravate this issue.
• It is generally advisable to take the medication with food to minimize gastrointestinal side effects.
• There are no specific food restrictions for Acefylline Piperazine, but maintaining a healthy diet is recommended for overall well-being.

Acefylline Piperazine 125mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension should be stored in a secure location, away from direct sunlight and moisture, preferably in a cool and dry place. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to avoid exposing the syrup to extreme temperatures, so refrain from storing it near heat sources or in damp areas like bathrooms. Always adhere to the expiration date indicated on the packaging, and if the medication is no longer needed or has expired, proper disposal is essential. Contact your pharmacist or healthcare professional for guidance on safe disposal methods, ensuring that the syrup is not flushed or poured down drains to prevent environmental contamination. Additionally, keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Acefylline Piperazine 125mg/5ml, Diphenhydramine 8mg/5ml Syrup/Suspension:

• Always adhere to the dosage prescribed by your doctor or healthcare professional.
• Shake the bottle vigorously to ensure uniform distribution of the medication.
• Administer the syrup with water, avoiding tea, coffee, or dairy products for optimal absorption.
• Maintain consistency by taking your dose at the same time daily.
• To minimize potential side effects, consider taking the syrup with food.
• Store the medication in a secure location, away from children's reach.
• Consult your doctor if you have any pre-existing medical conditions or are taking other medications.