Celstar (200mg) 10 Capsules

Celecoxib works by selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme, which plays a key role in the production of prostaglandins. Prostaglandins are chemicals that promote inflammation, pain, and fever at the site of injury or inflammation. By inhibiting COX-2, Celecoxib reduces the synthesis of these inflammatory prostaglandins, leading to a decrease in pain, swelling, and fever. Unlike non-selective NSAIDs, which inhibit both COX-1 and COX-2 enzymes, Celecoxib primarily targets COX-2, which helps minimize some of the gastrointestinal side effects that are often seen with other NSAIDs.

Celecoxib 200mg

Selective COX-2 Inhibitors

Capsule

The following are the uses of Celecoxib 200 mg Capsule:

• Treatment of osteoarthritis to relieve pain and inflammation.
• Management of rheumatoid arthritis to reduce joint pain and stiffness.
• Relief of acute pain, such as pain after surgery or injury.
• Treatment of primary dysmenorrhea (painful menstrual cramps).
• Management of ankylosing spondylitis to reduce pain and inflammation.
• Treatment of juvenile rheumatoid arthritis in children (under medical supervision).
• Relief of pain associated with other inflammatory conditions, as directed by a healthcare provider.

Following are the doses of Celecoxib 200 mg Capsule:

• The usual starting dose for osteoarthritis and rheumatoid arthritis in adults is 200 mg once daily or 100 mg twice daily, depending on the severity of symptoms.
• For acute pain, the recommended dose is 400 mg on the first day, followed by 200 mg once daily or 100 mg twice daily as needed.
• For primary dysmenorrhea, the typical dose is 400 mg on the first day, followed by 200 mg once daily or as prescribed by a healthcare provider.
• In cases of ankylosing spondylitis, the recommended dose is usually 200 mg once daily or 100 mg twice daily.
• Dosing for children with juvenile rheumatoid arthritis is typically 2 mg/kg twice daily, with the total daily dose not exceeding 200 mg.

In case of an overdose of Celecoxib 200 mg Capsule immediate medical attention should be sought. Overdose symptoms may include severe stomach pain, nausea, vomiting, dizziness, and drowsiness. It is important not to attempt self-treatment or induce vomiting without consulting a healthcare provider. Treatment may involve supportive care, including monitoring vital signs, and in some cases, gastric lavage or activated charcoal may be administered if the overdose is recent.

If you miss a dose of Celecoxib 200 mg Capsule, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for a missed dose, as this may increase the risk of side effects.

To use Celecoxib 200 mg Capsule, follow the instructions provided by your healthcare provider or as indicated on the prescription label. Typically, it should be taken once or twice daily, with or without food. Swallow the capsule whole with a glass of water. Do not crush, chew, or break the capsule. It's important to take the medication at the same time each day to help you remember and maintain consistent levels in your body.

Following are the situations when Celecoxib 200 mg Capsule should not be used:

• Should not be used in individuals with a known allergy to Celecoxib or any of its components.
• Contraindicated in patients with a history of hypersensitivity reactions to other NSAIDs, including sulfonamides.
• Should not be used in individuals with active gastrointestinal bleeding or peptic ulcers.
• Contraindicated in patients with severe heart failure or a history of cardiovascular events, such as heart attack or stroke.
• Should not be used during the third trimester of pregnancy due to potential harm to the developing fetus.
• Not recommended for use in patients with severe liver or kidney impairment unless specifically directed by a healthcare provider.

The side effects of Celecoxib 200 mg Capsule may include:

• Stomach upset or indigestion
• Headache
• Dizziness or lightheadedness
• Swelling or fluid retention
• Rash or itching
• Diarrhea or constipation
• High blood pressure
• Shortness of breath or chest pain (in rare cases)
• Gastrointestinal bleeding or ulcers
• Heart attack or stroke
• Severe allergic reactions, such as swelling of the face, throat, or difficulty breathing
• Liver or kidney problems

Following are the precautions and warnings for Celecoxib 200 mg Capsule:

• Should be used with caution in individuals with a history of heart disease, high blood pressure, stroke, or blood clotting disorders, as it may increase the risk of cardiovascular events.
• Should not be used in patients with a known allergy to Celecoxib, other NSAIDs, or sulfonamides.
• Use with caution in individuals with a history of gastrointestinal problems, such as ulcers, bleeding, or Crohn's disease.
• Not recommended for use during the third trimester of pregnancy as it may harm the developing fetus.
• Should be avoided in patients with severe liver or kidney impairment unless advised by a healthcare provider.
• Use with caution in older adults, as they may be more prone to side effects such as gastrointestinal bleeding or kidney problems.
• Celecoxib may interact with other medications, such as blood thinners, diuretics, or other NSAIDs, so inform your healthcare provider about all medications you are taking.
• Long-term use or high doses may increase the risk of heart attack, stroke, and gastrointestinal bleeding.

Following are the drug interactions for Celecoxib 200 mg Capsule:

• Should not be used in combination with other NSAIDs (e.g., ibuprofen, naproxen) as it may increase the risk of gastrointestinal side effects, such as bleeding or ulcers.
• Caution is advised when taking Celecoxib with anticoagulants (e.g., warfarin), as it may increase the risk of bleeding.
• Use with caution in patients taking ACE inhibitors, angiotensin II receptor antagonists, or diuretics for high blood pressure, as Celecoxib may reduce the effectiveness of these medications.
• May interact with lithium, increasing the risk of lithium toxicity.
• Corticosteroids (e.g., prednisone) used alongside Celecoxib may increase the risk of gastrointestinal side effects.
• Concomitant use with other blood thinners (e.g., aspirin, clopidogrel) may increase the risk of bleeding complications.
• Methotrexate levels may be elevated when taken with Celecoxib, increasing the risk of toxicity.
• Cytochrome P450 enzyme inhibitors (e.g., fluconazole, ketoconazole) may increase Celecoxib levels in the blood, enhancing the risk of side effects.

Following are the food interactions for Celecoxib 200 mg Capsule:

• Alcohol should be avoided while taking Celecoxib, as it may increase the risk of gastrointestinal bleeding and liver damage.
• There are no specific food interactions with Celecoxib; however, it is recommended to take the medication with food if it causes stomach upset.
• Consuming high-fat meals may delay the absorption of Celecoxib but will not significantly affect its overall effectiveness.
• While Celecoxib does not have direct interactions with food, it’s advisable to maintain a balanced diet to support overall health and prevent potential gastrointestinal discomfort.

Celecoxib 200 mg Capsule should be stored at room temperature, away from direct light, heat, and moisture. It is important to keep the medication in its original container, tightly closed, to protect it from environmental factors that could affect its stability. Store the capsules in a dry place, out of reach of children and pets, to prevent accidental ingestion. Do not store the medication in the bathroom, as the humidity may degrade the drug. When it comes to disposal, do not flush Celecoxib down the toilet or pour it into a drain unless specifically instructed to do so. Instead, ask your pharmacist or healthcare provider for guidance on how to safely dispose of any unused or expired medication. In some cases, your pharmacy may have a medication take-back program. Proper disposal ensures that the drug does not harm the environment or pose a risk to others.

Following are the quick tips for Celecoxib 200 mg Capsule:

• Take Celecoxib exactly as prescribed by your healthcare provider to get the best results.
• Take the medication with food if you experience stomach upset to reduce the risk of gastrointestinal discomfort.
• Swallow the capsule whole with a glass of water. Do not crush, chew, or break the capsule.
• Take Celecoxib at the same time each day to help you remember and maintain consistent levels of the medication in your body.
• Avoid drinking alcohol while taking Celecoxib to reduce the risk of gastrointestinal bleeding and liver issues.
• Inform your doctor about all other medications you are taking to avoid potential drug interactions.
• Do not stop taking Celecoxib suddenly without consulting your healthcare provider, even if you start feeling better.

Celecoxib 200 mg Capsule does not typically require routine laboratory screening or monitoring. However, in certain cases, the following may be considered:

• Regular blood pressure monitoring, especially for those with a history of hypertension or cardiovascular disease, as Celecoxib may increase the risk of high blood pressure.
• Periodic kidney and liver function tests, particularly in patients with existing kidney or liver conditions, to ensure that the medication is not causing adverse effects on these organs.
• Monitoring for signs of gastrointestinal bleeding, especially in patients with a history of ulcers or gastrointestinal issues.
• Routine screening for any signs of cardiovascular events, especially for long-term users, to detect any potential complications early.