CERTICAN 0.25MG TAB

Sirolimus 25MG Tablet, also known as rapamycin, is a potent immunosuppressant that primarily acts by inhibiting the mammalian target of rapamycin (mTOR). mTOR is a serine/threonine kinase that regulates cell growth, proliferation, and survival. By binding to the intracellular protein FK-binding protein 12 (FKBP12), sirolimus forms a complex that directly inhibits mTOR complex 1 (mTORC1). This inhibition blocks the downstream signaling pathways involved in cell cycle progression, specifically at the G1 to S phase transition. As a result, sirolimus prevents the activation and proliferation of T-lymphocytes, thereby suppressing the immune response and reducing inflammation.

Immunosuppressant

Tablet

The following are the uses of Sirolimus 25MG Tablet:

• Used for preventing organ rejection after a transplant surgery.
• Used to treat certain lung or kidney diseases.
• Used to suppress the immune system and reduce inflammation.
• Used in conditions like lymphangioleiomyomatosis and pulmonary lymphangioleiomyomatosis.
• Used for managing certain types of cancer.
• Used to inhibit cell growth and multiplication.
• Used to treat autoimmune conditions, providing symptom relief.

In the case of an overdose of Sirolimus 25MG Tablets, immediate medical attention is required. Symptoms of an overdose may include difficulty breathing, severe headache, chest pain, and rapid heart rate. It is important to contact a healthcare professional or go to the nearest emergency room if you suspect an overdose. Prompt treatment can help manage symptoms and prevent potential complications associated with excessive Sirolimus intake. Always store medications out of reach of children to minimize the risk of accidental ingestion.

In the case of a missed dose of Sirolimus 25MG Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to safely adjust your medication regimen. It is crucial to maintain a consistent dosing routine for this medication.

To take Sirolimus 25MG Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, as directed by your healthcare professional, and do not break, crush, or chew the tablet.

Following are the conditions or situations when Sirolimus 25MG Tablet should not be used:

• Avoid in individuals with a known allergy or hypersensitivity to sirolimus or other similar drugs.
• Not recommended for use during pregnancy as it may cause harm to the fetus.
• Contraindicated in breastfeeding women as it can pass into breast milk.
• Should not be used in patients with severe liver disease or liver impairment.
• Avoid if you have a history of or current lung disease or breathing problems.
• Not suitable for individuals with a history of severe or multiple drug allergies.
• Sirolimus should not be used in patients with uncontrolled or severe infections.
• Do not use if you have a history of or are at risk for lymphoma or other cancers.
• Avoid if you have recently received a live vaccine.
• Contraindicated in patients with severe kidney disease or kidney impairment.
• Not recommended for individuals with a history of stroke or transient ischemic attack (TIA).

The side effects of Sirolimus 25MG Tablet may include:

• Swelling in the arms or legs
• High blood pressure
• Increased risk of infections
• Nausea and vomiting
• Diarrhea
• Mouth ulcers
• Skin rash or itching
• Elevated cholesterol levels

Following are the precautions and warnings for Sirolimus 25MG Tablet:

• Sirolimus should be used with caution in patients with a history of liver or kidney disease as it may affect their function.
• Regular monitoring of blood levels and liver function tests is necessary while on this medication.
• This medication can weaken the immune system, making patients more susceptible to infections. Avoid contact with anyone who has an infection.
• Sirolimus may increase the risk of developing lymphoma and other types of cancers. Long-term use should be carefully monitored.
• It may cause hyperlipidemia, so regular monitoring of cholesterol and triglyceride levels is recommended.
• Patients should avoid live vaccines during treatment as it may reduce the effectiveness of the vaccine and increase the risk of infection.
• Elderly patients may be more sensitive to the side effects, so dosage adjustments might be necessary.

Following are the drug interactions for Sirolimus 25MG Tablet:

• Avoid using live vaccines with Sirolimus as it may reduce their effectiveness.
• Sirolimus levels can be increased by CYP3A4 inhibitors like ketoconazole, verapamil, and clarithromycin, potentially leading to toxicity.
• CYP3A4 inducers such as rifampin, phenytoin, and St. John's Wort can decrease Sirolimus concentrations, reducing its effectiveness.
• Sirolimus may increase the blood levels of cyclosporine, tacrolimus, and everolimus, leading to toxicity.
• Combining Sirolimus with other immunosuppressants or protease inhibitors may increase the risk of infection and other side effects.
• Antifungal medications like itraconazole and voriconazole can increase Sirolimus levels, requiring careful monitoring.
• Proton pump inhibitors (PPIs) like omeprazole may reduce Sirolimus absorption, affecting its effectiveness.

Following are the food interactions for Sirolimus 25MG Tablet:

• Avoid consuming grapefruit and grapefruit juice as they can significantly increase the levels of Sirolimus in your blood by inhibiting the enzyme CYP3A4, leading to a higher risk of side effects, especially kidney issues.
• Alcohol consumption should be minimized or avoided as it can increase the risk of liver problems and may affect the metabolism of Sirolimus.
• High-fat meals can increase the absorption of Sirolimus, potentially leading to higher blood levels and an increased risk of side effects.
• Garlic supplements may decrease the effectiveness of Sirolimus by altering its metabolism.
• St. John's Wort should be avoided as it can reduce the blood levels of Sirolimus, making it less effective.
• Vitamin E supplements should be used with caution as they can also reduce the effectiveness of Sirolimus.
• It is advisable to maintain a consistent diet, especially regarding fat content, as this can affect the absorption and distribution of Sirolimus.
• Always consult your healthcare provider for specific dietary recommendations and adjustments during Sirolimus therapy.

Sirolimus 25MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, heat, and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from environmental factors. It is crucial not to store the medication in the bathroom due to its humidity, and avoid placing it near the kitchen sink or stove to prevent exposure to heat and moisture. Always check the expiration date, and if the tablets are expired or no longer needed, do not flush them down the toilet or throw them into the trash. Instead, consult your pharmacist or local waste disposal company for instructions on safe disposal methods to protect the environment and prevent misuse. Keep the medication out of children's reach to ensure their safety.

Following are the quick tips for Sirolimus 25MG Tablet:

• Consult your doctor for personalized dosage instructions based on your medical condition.
• Swallow the tablet whole; do not crush, chew, or break it to maintain its effectiveness.
• Take the tablet at the same time each day to ensure consistent blood levels.
• Sirolimus may interact with other medications; disclose all medicines you're taking to your doctor.
• Avoid grapefruit and grapefruit juice as they can affect the metabolism of Sirolimus.
• Regular blood tests may be required to monitor Sirolimus levels and kidney function.
• Inform your doctor if you experience side effects like nausea, diarrhea, or headaches.
• Store Sirolimus tablets properly, as directed, to maintain their potency.