CERTICAN 0.75MG TAB

CERTICAN 0.75MG TAB

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  • Manufacturer NOVARTIS PHARMACEUTICALS (PVT.) LTD.
  • Generic Name Sirolimus

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Sirolimus 75MG Tablet, also known as rapamycin, primarily exerts its immunosuppressive and antiproliferative effects by binding to the intracellular protein FK binding protein-12 (FKBP-12). This drug-protein complex then inhibits the mammalian target of rapamycin (mTOR), a crucial kinase involved in cell signaling pathways. By blocking mTOR, sirolimus interferes with various cellular processes, including cell growth, proliferation, and survival. It specifically inhibits the activation and proliferation of T cells, a type of white blood cell, thereby suppressing the immune response. This mechanism of action is central to the drug's use in preventing organ rejection in transplant recipients and treating certain medical conditions where immunosuppression is required.

  • Ingredients

    Sirolimus
  • Drug Class

    Immunosuppressant

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Sirolimus 75MG Tablet:

    • Used for preventing organ rejection in transplant patients.
    • Used to suppress the immune system and reduce inflammation.
    • Used in the treatment of certain cancers, particularly kidney and brain tumors.
    • Used for managing Lymphangioleiomyomatosis, a lung disease.
    • Used to treat a rare genetic disease called Tuberous Sclerosis Complex.
    • Used to control severe asthma in specific cases.
    • Used to support coronary artery angioplasty procedures.
  • In case of Overdose

    In the case of an overdose of Sirolimus 75MG Tablets, individuals may experience severe side effects, including gastrointestinal issues, elevated blood pressure, and increased risk of infections. It is important to seek medical assistance promptly if an overdose is suspected. Symptoms of overdose may include nausea, vomiting, diarrhea, and in severe cases, kidney problems or decreased platelet count. Timely intervention and medical monitoring are crucial to managing and mitigating the potential risks associated with this medication.

  • Missed Dose

    In the case of a missed dose of Sirolimus 75MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen and ensure the best treatment outcome.

  • How To Use

    To take Sirolimus 75MG Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically taken once daily without food or as directed by your doctor.

  • When Not to Use

    Following are the conditions/situations when Sirolimus 75MG Tablet should not be used:

    • Must not be taken if you are allergic to Sirolimus or any other macrolide immunosuppressants.
    • Avoid using if you have severe liver or kidney disease.
    • Do not use if you are pregnant or breastfeeding, as it can harm the unborn baby or infant.
    • Not suitable for individuals with uncontrolled infections or active infections, including tuberculosis.
    • Should not be taken if you have a history of or current lung disease or breathing problems.
    • Contraindicated for patients with a history of stroke or transient ischemic attack (TIA).
    • Do not use if you have a history of or are at risk for angioedema (swelling of the face, lips, tongue, or throat).
    • Not recommended for individuals with a history of malignancies or skin cancers.
    • Avoid if you have recently received a live vaccine or are planning to receive one.
    • Do not administer to patients with a history of severe or untreated skin conditions, such as eczema or psoriasis.
  • Side Effects

    The side effects of Sirolimus 75mg Tablet may include:

    • Nausea or vomiting
    • Diarrhea
    • Abdominal pain
    • Headache
    • Rash or skin reactions
    • Elevated blood pressure
    • Increased risk of infections
    • Mouth ulcers or sores
    • Decreased appetite
    • Swelling in the hands, feet, or legs
    • Joint pain or muscle weakness
    • Elevated blood sugar levels
    • Liver enzyme abnormalities
    • Increased cholesterol or triglycerides
    • Difficulty breathing or shortness of breath
    • Rare allergic reactions such as rash, itching, or swelling
  • Precautions & Warnings

    Following are the precautions and warnings for Sirolimus 75MG Tablet:

    • Do not start or stop the medication without consulting your doctor, as sudden changes in dosage may lead to serious side effects.
    • Regular monitoring of blood levels, liver and kidney function is necessary while taking this medication to ensure safe and effective use.
    • Sirolimus may cause immunosuppression, increasing the risk of infections. Report any signs of infection to your doctor immediately.
    • Avoid live vaccines during treatment as the immune response may be affected. Discuss vaccination schedules with your healthcare provider.
    • This medication may cause high blood sugar (hyperglycemia) and cholesterol levels; regular monitoring is required.
    • Patients with a history of bleeding problems or who are taking blood thinners should exercise caution, as Sirolimus may increase the risk of bleeding.
    • Pregnant and breastfeeding women should consult their doctor before taking Sirolimus, as it may cause harm to the fetus or infant.
    • Inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.
  • Drug Interactions

    Following are the drug interactions for Sirolimus 75MG Tablet:

    • Sirolimus can interact with CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, grapefruit juice) leading to increased sirolimus levels and potential toxicity.
    • CYP3A4 inducers (e.g., rifampin, St. John's Wort) can decrease sirolimus concentrations, reducing its effectiveness.
    • Sirolimus may increase the plasma levels of cyclosporine, tacrolimus, and everolimus, requiring careful monitoring and dose adjustments.
    • The use of live vaccines should be avoided due to potential immunosuppression, which can result in severe infections.
    • Non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of bleeding, as sirolimus can impair platelet function.
    • Combining sirolimus with other immunosuppressants, such as azathioprine or mycophenolate mofetil, may increase the risk of infections and other adverse effects.
    • Antacids containing magnesium or aluminum can reduce the absorption of sirolimus, thus reducing its effectiveness.
  • Food Interactions

    Following are the food interactions to be aware of when taking Sirolimus 75MG Tablet:

    • Grapefruit and grapefruit juice should be avoided as they can significantly increase Sirolimus blood levels, leading to potential toxicity.
    • Avoid consuming large amounts of cranberry juice as it may affect Sirolimus metabolism.
    • Consuming high-fat meals while taking Sirolimus may increase the absorption of the medication.
    • Avoid alcohol consumption as it can increase the risk of liver toxicity and may negatively interact with Sirolimus.
    • Avoid St. John's Wort as it can reduce the effectiveness of Sirolimus.
    • Do not consume Seville oranges (often used in marmalades) as they can affect Sirolimus levels in the blood.
    • Always consult your healthcare provider for specific dietary guidelines while taking Sirolimus.
    • Ensure you follow the prescribed dosage and duration of treatment for optimal results.
  • Storage/Disposal

    Sirolimus 75MG Tablets should be stored in a secure and controlled environment, preferably in a cool and dry place at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to store the medication in the bathroom or near heat sources, as temperature fluctuations can impact its effectiveness. Proper disposal of Sirolimus is essential; do not dispose of it by flushing or pouring down the drain. Consult your pharmacist or healthcare provider for specific instructions on safe disposal methods. Keep the medication away from children to prevent accidental consumption, ensuring their safety.

  • Quick Tips, if any

    Following are the quick tips for Sirolimus 75MG Tablet:

    • Consult your doctor for the right dosage and duration tailored to your medical condition.
    • Swallow the tablet whole without crushing or chewing for optimal absorption.
    • Take it at the same time each day to maintain consistent blood levels.
    • Ensure you complete the full prescribed course, even if you feel better earlier.
    • Avoid grapefruit juice and its products while on this medication.
    • Regularly monitor your blood pressure, blood sugar, and cholesterol levels as advised by your doctor.
    • Store the tablets at room temperature, away from excessive heat and moisture.
    • Keep all medications out of children's reach to prevent accidental consumption.

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