Children's Panadol (160mg/5ml) 120ml Liquid

Paracetamol 160mg/5ml syrup/suspension primarily exerts its analgesic and antipyretic effects through its active metabolite, which is believed to inhibit the synthesis of prostaglandins in the central nervous system. This inhibition reduces the sensitivity of pain receptors and the heat-regulating center in the brain, thereby providing pain relief and reducing fever. The exact site of action within the hypothalamus remains a subject of ongoing research, but it is thought to involve the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, which play a role in the production of inflammatory mediators.

Analgesic/antipyretic

Suspension

The following are the uses of Paracetamol 160mg/5ml Syrup/Suspension:

• Used for relieving mild to moderate pain such as headaches, toothaches, and post-vaccination fever.
• Used to reduce fever and ease discomfort in children and babies.
• Effective for treating symptoms of cold and flu, including sore throat and body aches.
• Helps manage pain and inflammation associated with minor injuries.
• Can be given to children to reduce pain and fever after medical procedures.
• Provides relief from mild arthritic and rheumatic pain.
• Suitable for managing menstrual cramps and discomfort.

In the case of an overdose of Paracetamol 160mg/5ml Syrup/Suspension, prompt action is necessary. Symptoms may include nausea, vomiting, and abdominal pain. Seek medical assistance immediately and provide healthcare professionals with details such as the estimated amount ingested and the time of overdose. They will determine the appropriate treatment, which may involve gastric decontamination and supportive care to manage symptoms and prevent potential liver damage.

In the case of a missed dose of Paracetamol 160mg/5ml Syrup/Suspension, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. For infants and children, ensure you carefully measure the correct amount using the measuring device provided. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed.

To administer Paracetamol 160mg/5ml Syrup/Suspension, shake the bottle well, use a measuring device like a syringe or spoon to extract 5ml, and give it to the patient orally, following the prescribed dosage and frequency instructions provided by the healthcare professional.

Following are the conditions/situations when Paracetamol 160mg/5ml Syrup/Suspension should not be used:

• Do not use if the patient is allergic to paracetamol or any other ingredients in the medication.
• Avoid in patients with severe liver disease or acute liver conditions.
• Not suitable for individuals with severe kidney impairment.
• Should not be used to treat fever in children after vaccination without a doctor's advice.
• Contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Avoid prolonged use without medical supervision to prevent potential liver damage.
• Not recommended for patients with severe heart disease or circulatory impairment.

The side effects of Paracetamol 160mg/5ml Syrup/Suspension may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Loss of appetite
• Skin rash or itching
• Allergic reactions (hives, swelling, difficulty breathing)
• Liver damage (in rare cases, prolonged use may lead to liver problems)
• Easy bruising or bleeding
• Fatigue and weakness

Following are the precautions and warnings for Paracetamol 160mg/5ml Syrup/Suspension:

• Do not exceed the recommended dosage, as Paracetamol overdose can cause severe liver damage.
• This medication is for oral use only; do not inject or use intravenously.
• Patients with liver or kidney problems should use this medication with caution and under medical supervision.
• Avoid long-term use without consulting a healthcare professional, as prolonged use may lead to liver or kidney issues.
• If symptoms persist or worsen, seek medical advice promptly.
• Paracetamol may interact with other medications; inform your doctor about all the medicines you are taking.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Paracetamol 160mg/5ml Syrup/Suspension:

• Prolonged use with opioids like codeine or tramadol may lead to increased risk of liver damage and respiratory depression.
• Paracetamol can potentially decrease the effectiveness of anticoagulants such as warfarin, requiring close monitoring of blood clotting times.
• When taken with anticonvulsants like carbamazepine, it may accelerate the metabolism of paracetamol, reducing its efficacy.
• The effectiveness of Paracetamol may be reduced when used with isoniazid, a tuberculosis medication.
• Co-administration with phenobarbital can increase the metabolism of paracetamol, potentially requiring higher doses for efficacy.
• Caution is advised when combining with chloramphenicol, as it may affect liver metabolism and increase the risk of side effects.
• Paracetamol may interact with certain HIV medications (e.g., ritonavir), potentially affecting liver function and requiring dose adjustments.

Following are the food interactions for Paracetamol 160mg/5ml Syrup/Suspension:

• Alcohol consumption should be limited or avoided as it can increase the risk of liver damage, especially when Paracetamol is taken in higher doses or for extended periods.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Paracetamol, potentially increasing its levels in the body and the risk of side effects.
• Avoid excessive caffeine intake from coffee, tea, or energy drinks, as it can increase the metabolism of Paracetamol, potentially reducing its effectiveness.
• High-fat meals may slightly delay the absorption of Paracetamol, but it generally has no significant impact on its overall effectiveness.
• Avoid excessive consumption of foods containing high levels of tyramine (aged cheeses, cured meats, fermented foods) as Paracetamol may interact with these compounds, potentially affecting blood pressure.
• Consuming a light meal or snack before taking Paracetamol syrup can help reduce the risk of gastrointestinal discomfort and improve the overall absorption of the medication.
• It is generally safe to take Paracetamol with most foods, but always follow the dosage instructions provided by your healthcare professional.
• If you have specific dietary concerns or conditions, consult your doctor or pharmacist for personalized advice.

Paracetamol 160mg/5ml Syrup/Suspension should be stored in a controlled environment, maintaining a cool and dry atmosphere at room temperature, typically between 20-25°C (68-77°F). Protect the medication from direct sunlight and moisture exposure to maintain its integrity. Always keep the bottle tightly sealed to prevent contamination. Avoid storing it in bathrooms or kitchens, as heat and humidity can degrade the medication. Regularly check the expiration date, and dispose of any unused or expired syrup responsibly. Do not dispose of it through household waste or sewage systems; instead, follow local guidelines or consult healthcare professionals for appropriate disposal methods. Ensure the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Paracetamol 160mg/5ml Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Measure the correct dose using the measuring cup provided.
• Administer the syrup orally, ensuring it is swallowed completely.
• Avoid giving this medication to children without medical advice.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not use if the syrup has changed color or developed an unusual odor.
• Consult your healthcare provider if symptoms persist or worsen after taking this medication.
• Inform your doctor about any other medications you are taking to avoid potential interactions.