CHLORAL HYDRATE 120ML SYP

CHLORAL HYDRATE 120ML SYP

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  • Manufacturer SPECIFIC RESEARCH LABORATORIES.
  • Generic Name

    Chloral hydrate

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Chloral hydrate syrup/suspension primarily exerts its effects through the formation of trichloroethanol, a metabolite produced by the liver. This metabolite acts as a sedative-hypnotic agent by modulating the gamma-aminobutyric acid (GABA) neurotransmitter system in the brain. It binds to specific sites associated with GABA receptors, enhancing the inhibitory effects of GABA on neuronal activity. This leads to decreased neuronal excitability, particularly in the cerebral cortex, resulting in sedative, hypnotic, and anxiolytic effects. The mechanism involves potentiating GABA-mediated chloride channel opening, increasing chloride conductance and hyperpolarizing neurons, which ultimately contributes to the central nervous system depressant actions of chloral hydrate.

  • Ingredients

    Chloral hydrate

  • Drug Class

    Sedative-hypnotic

  • Dosage Form

    Syrup

  • Uses

    The following are the uses of Chloral hydrate Syrup/Suspension:

    • Used for inducing sleep and treating insomnia
    • Used as a sedative to calm anxiety and agitation
    • Used for facilitating medical procedures requiring sedation
    • Used for managing symptoms of alcohol withdrawal
    • Used to control seizures in certain cases
    • Used for treating insomnia in children due to behavioral issues
    • Used as a pre-anesthetic agent before surgeries
    • Used in combination with other medications for specific treatments
  • In case of Overdose

    In the case of an overdose of Chloral hydrate Syrup/Suspension, it is important to act swiftly. The symptoms may include severe drowsiness, confusion, difficulty breathing, and loss of consciousness. If you or someone you know has ingested an excessive amount, contact emergency services immediately. Quick response is vital, as prompt medical intervention can significantly impact the outcome. It is crucial to provide accurate information about the quantity ingested to assist healthcare professionals in providing appropriate treatment.

  • Missed Dose

    In the case of a missed dose of Chloral Hydrate Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent dosing routine, but if you frequently miss doses, consult your healthcare provider for advice on how to manage your medication effectively.

  • How To Use

    To take Chloral Hydrate Syrup/Suspension, shake the bottle well, then measure the prescribed dose using an oral syringe or a measuring cup, and administer it orally as directed by your healthcare professional, typically before bedtime, ensuring you follow the recommended dosage for your specific condition.

  • When Not to Use

    Following are the conditions or circumstances when Chloral hydrate Syrup/Suspension should not be taken:

    • Should not be used in individuals with a known allergy or hypersensitivity to chloral hydrate or its components.
    • Contraindicated in patients with severe hepatic or renal impairment due to the risk of accumulation and toxicity.
    • Should not be used in individuals with a history of drug or alcohol addiction, as it has sedative and addictive properties.
    • Not recommended for use in patients with severe respiratory conditions, such as sleep apnea or respiratory depression.
    • Should be avoided during pregnancy and breastfeeding unless prescribed by a healthcare provider, as it may harm the fetus or infant.
    • Not suitable for individuals with a history of hypersensitivity reactions to sedative-hypnotic medications.
    • Should not be given to children unless under strict medical supervision, as it requires precise dosing.
    • Caution is required in elderly patients due to the increased risk of sedation and confusion.
  • Side Effects

    The side effects of Chloral Hydrate Syrup/Suspension may include:

    • Dizziness or lightheadedness
    • Nausea and vomiting
    • Stomach pain or discomfort
    • Confusion or disorientation
    • Skin rash or itching
    • Sleepiness during the day
    • Increased heart rate
    • Respiratory depression (slow or shallow breathing)
  • Precautions & Warnings

    Following are the precautions and warnings for Chloral Hydrate Syrup/Suspension:

    • This medication should be used with caution in elderly patients as they may be more sensitive to its effects and the risk of side effects may increase.
    • Chloral Hydrate should not be used in patients with severe liver disease or liver impairment as it can lead to serious complications.
    • It should be avoided in individuals with a history of depression, as it may exacerbate the condition.
    • Patients with a history of seizures or epilepsy should use this medication with caution as it may lower the seizure threshold.
    • Chloral Hydrate may cause dizziness and drowsiness, so patients should avoid driving, operating heavy machinery, or performing tasks that require mental alertness until they know how the medication affects them.
    • Long-term use of Chloral Hydrate should be monitored closely due to the potential risk of dependence and withdrawal symptoms upon discontinuation.
    • It is important to follow the prescribed dosage and not exceed the recommended duration of treatment to minimize the risk of adverse effects.
  • Drug Interactions

    Following are the drug interactions for Chloral Hydrate Syrup/Suspension:

    • Alcohol and other central nervous system (CNS) depressants like opioids or benzodiazepines can have additive effects, leading to increased sedation, respiratory depression, and potential overdose.
    • Chloral hydrate may decrease the effectiveness of hormonal birth control methods, potentially reducing their contraceptive effect.
    • It can interact with certain antibiotics, such as rifampin, which may increase the metabolism of chloral hydrate, reducing its effectiveness.
    • The effect of barbiturates may be enhanced by chloral hydrate, potentially leading to increased sedation and respiratory depression.
    • Anticonvulsant medications may have their blood levels affected by chloral hydrate, possibly requiring dosage adjustments.
    • Drugs that affect the liver's cytochrome P450 enzyme system can alter the metabolism of chloral hydrate, impacting its effectiveness and side effects.
    • Chloral hydrate may increase the risk of bleeding when taken with anticoagulant medications, requiring close monitoring.
  • Food Interactions

    Following are the food interactions to consider with Chloral hydrate Syrup/Suspension:

    • Avoid consuming alcohol as it can increase the sedative effects of Chloral hydrate, leading to excessive drowsiness and impaired coordination.
    • Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Chloral hydrate, potentially altering its effectiveness.
    • Caffeine-containing beverages like coffee and tea might interfere with the sedative action of Chloral hydrate, reducing its effectiveness.
    • Fatty meals may slightly delay the absorption of Chloral hydrate, but this effect is usually not clinically significant.
    • Dairy products like milk can be mixed with Chloral hydrate syrup to improve its taste, but it may slightly delay the onset of action.
    • Avoid herbal remedies like St. John's Wort as it can affect the metabolism of Chloral hydrate, potentially altering its efficacy.
    • Always follow the dosage instructions provided by your healthcare professional to ensure the medication's effectiveness.
    • Consult your doctor or pharmacist for personalized advice regarding any specific food interactions based on your health condition.
  • Storage/Disposal

    Chloral hydrate Syrup/Suspension requires careful storage and disposal to ensure safety. Store it in a cool and dry area, away from sunlight and moisture, ideally at room temperature. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid extreme temperatures by not storing it in bathrooms or near heat sources. Always check the expiration date, and if expired or no longer needed, dispose of it properly. Do not dispose of it through household waste or water systems; instead, consult a pharmacist or healthcare professional for guidance on safe disposal practices. Keep the medication securely stored away from children to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Chloral Hydrate Syrup/Suspension:

    • Administer the syrup as directed by your physician, adhering to the prescribed dosage and timing.
    • Before each use, shake the bottle vigorously to ensure the medication is properly mixed.
    • Always measure the dose accurately using the provided measuring device.
    • Ensure you swallow the syrup completely, followed by a glass of water.
    • Avoid consuming alcohol while taking this medication as it may intensify its effects.
    • Store the syrup at room temperature, away from direct sunlight and moisture.
    • Dispose of any unused or expired medication safely and responsibly.

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