Chole-D3 (60000IU) 40 Softgel Capsules

Cholecalciferol, also known as vitamin D3, has a primary mechanism of action that involves regulating calcium and phosphate metabolism in the body. When Cholecalciferol 60,000 IU is administered, it is absorbed in the small intestine and enters the bloodstream. The liver then converts cholecalciferol into 25-hydroxyvitamin D (calcidiol), which is further metabolized in the kidneys to form the active form of vitamin D, 1,25-dihydroxyvitamin D (calcitriol). Calcitriol acts as a hormone, binding to vitamin D receptors (VDR) in various target tissues, including the intestines, bones, and kidneys. This binding activates specific genes that increase the absorption of calcium and phosphate from the intestines, promote bone mineralization, and enhance renal reabsorption of calcium, thereby contributing to the maintenance of calcium homeostasis and optimal bone health.

Cholecalciferol 60,000iu

Vitamin D3 analog

Capsule

The following are the uses of Cholecalciferol 60,000iu Capsule:

• Used for treating and preventing Vitamin D deficiency, ensuring proper bone development and overall health.
• Used to manage conditions like rickets, osteomalacia, and osteoporosis, which are caused by low Vitamin D levels.
• Used to support calcium absorption, promoting stronger bones and teeth.
• Used in patients with limited sun exposure, dark skin, or conditions affecting Vitamin D absorption.
• Used to regulate the immune system and reduce the risk of certain diseases.
• Used to improve muscle strength and overall physical performance.
• Used as a supplement during pregnancy and breastfeeding to maintain adequate Vitamin D levels.
• Used to support overall health and well-being, especially in individuals with certain medical conditions.

In the case of an overdose of Cholecalciferol 60,000 IU capsules, individuals may experience symptoms such as nausea, vomiting, constipation, and a general feeling of weakness. An excessive intake can lead to a condition called hypervitaminosis D, causing an increase in calcium levels in the blood. If an overdose is suspected, seek medical advice promptly, and ensure you provide details of the medication, dosage, and time of ingestion to assist healthcare professionals in determining the best course of action.

In the case of a missed dose of Cholecalciferol 60,000 IU Capsule, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may lead to an excessive intake of Vitamin D. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication regimen.

To take Cholecalciferol 60,000 IU capsules, swallow the capsule whole with a glass of water, preferably with a meal or as directed by your healthcare professional, ensuring adherence to the prescribed dosage schedule.

Here are the conditions and situations when Cholecalciferol 60,000 IU Capsule should not be taken:

• Do not take if you have a known hypersensitivity or allergy to Cholecalciferol or any of the excipients in the capsule.
• Avoid using this supplement if you have a condition called hypervitaminosis D, where vitamin D levels are already excessively high.
• Not suitable for individuals with elevated calcium levels in the blood (hypercalcemia) or those with conditions causing hypercalcemia.
• Contraindicated in patients with kidney stones or conditions that increase the risk of developing kidney stones.
• Should not be used in individuals with conditions causing excessive calcium excretion in the urine (hypercalciuria).
• Avoid using this dose if you have conditions causing abnormal bone formation or calcification in soft tissues.

The side effects of Cholecalciferol 60,000 IU Capsule may include:

• Nausea and vomiting
• Weakness and fatigue
• Dry mouth
• Metallic taste
• Loss of appetite
• Constipation or diarrhea
• Muscle or joint pain
• Increased calcium levels in the blood (hypercalcemia)

Following are the precautions and warnings for Cholecalciferol 60,000iu Capsule:

• Individuals with a known hypersensitivity or allergy to Cholecalciferol or any of its ingredients should not take this medication.
• Patients with a history of kidney stones or kidney disease should exercise caution and consult a doctor, as vitamin D supplementation can affect calcium metabolism.
• Those with hypercalcemia (high calcium levels in the blood) should not take this medication as it may worsen the condition.
• It is important to monitor calcium and phosphate levels during long-term therapy, especially in patients with a history of hyperphosphatemia.
• Cholecalciferol capsules should be swallowed whole and not chewed, crushed, or opened, as this may affect the absorption of the medication.
• Patients with malabsorption syndromes may require higher doses or alternative forms of vitamin D supplementation.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as vitamin D requirements may vary during these periods.
• Keep this medication out of reach of children and pets, and store it in a cool, dry place as directed.

Following are the drug interactions for Cholecalciferol 60,000 IU Capsule:

• Thiazide diuretics, such as hydrochlorothiazide, can reduce the excretion of vitamin D, potentially leading to hypercalcemia.
• Anticonvulsants like phenytoin and phenobarbital may decrease the effectiveness of vitamin D by increasing its metabolism.
• Cholestyramine, a bile acid sequestrant, can bind to vitamin D in the intestine and reduce its absorption.
• Orlistat, a weight-loss medication, may decrease the absorption of fat-soluble vitamins, including vitamin D.
• Calcium carbonate supplements can compete for absorption with vitamin D, affecting the overall calcium and vitamin D balance.
• Aluminum-containing antacids may reduce the absorption of vitamin D, potentially requiring adjustments in dosing.
• Corticosteroids like prednisone can increase vitamin D metabolism, potentially requiring higher doses of vitamin D to maintain adequate levels.
• Ketoconazole, an antifungal medication, may impair vitamin D metabolism, leading to reduced vitamin D levels.

Following are the food interactions for Cholecalciferol 60,000 IU Capsule:

• Avoid excessive consumption of foods rich in vitamin D, such as fatty fish (salmon, mackerel), egg yolks, and fortified dairy products, as it may lead to vitamin D toxicity.
• Maintain a balanced diet with moderate amounts of vitamin D-rich foods to prevent potential overdose.
• Consuming foods high in calcium, like dairy products, dark leafy greens, and calcium-fortified foods, can enhance the absorption of Cholecalciferol.
• Certain mineral oils and orlistat (a weight-loss medication) may reduce the absorption of vitamin D, so consider timing doses appropriately.
• Avoid high-fiber foods and antacids containing magnesium or aluminum, as they can interfere with vitamin D absorption.
• Grapefruit juice may affect the metabolism of vitamin D, so it's best to avoid it during treatment.
• Alcohol may decrease the effectiveness of vitamin D supplements, so limit or avoid alcohol consumption.
• Always follow the advice of your healthcare provider regarding diet and medication adjustments.

Cholecalciferol 60,000iu Capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the capsules in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing them in bathrooms or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Regularly check the expiration date, and dispose of expired or unused capsules responsibly; do not flush them or pour them down the drain. For proper disposal methods, consult your pharmacist or local waste management guidelines. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Cholecalciferol 60,000iu Capsule:

• Consult a doctor or healthcare professional for proper dosage and duration of treatment.
• Take the capsule as directed, typically with or after a meal.
• Ensure you swallow the capsule whole without crushing or chewing for optimal absorption.
• Maintain a consistent schedule for taking the medication as prescribed.
• Avoid missing doses; if you miss a dose, take it as soon as you remember, unless it's close to your next dose.
• Inform your doctor about all medications and supplements you're taking to prevent potential interactions.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.