CHYMOTRYPSINE INJ

Chymotrypsin injection works by hydrolyzing certain peptide bonds in proteins, specifically those formed by the amino acids tyrosine, phenylalanine, and tryptophan. It is a proteolytic enzyme that selectively cleaves peptide bonds adjacent to these aromatic amino acids, leading to the breakdown of proteins into smaller peptides and amino acids. This enzymatic action aids in the digestion and absorption of proteins in the gastrointestinal tract, helping to alleviate conditions where protein digestion may be compromised.

Chymotrypsin

proteolytic enzyme.

Injection

The following are the uses of Chymotrypsin Injection:

• Used for treating digestive disorders where the body struggles to absorb nutrients, especially in cases of cystic fibrosis.
• Used for managing conditions where food leaves the stomach too quickly (gastroenteritis) or too slowly (gastroparesis).
• Used for aiding in the diagnosis of pancreatic function and gastrointestinal issues.
• Used for reducing inflammation and promoting healing in certain bowel disorders.
• Used for improving digestion and nutrient absorption after bowel surgery or injury.
• Used for managing certain cases of pancreatic insufficiency, ensuring proper digestion.
• Used for relieving symptoms of indigestion and malabsorption in various gastrointestinal diseases.

In the case of an overdose of Chymotrypsin Injection, symptoms may include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Other potential effects could be increased pain and swelling at the injection site, as well as systemic reactions like rash, itching, or difficulty breathing. Prompt medical intervention is required to manage these symptoms, which may involve supportive care and treatment to alleviate the specific adverse effects experienced by the patient.

In the case of a missed dose of Chymotrypsin Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to get back on track with your treatment plan. It is essential to maintain consistency in taking this medication for optimal therapeutic benefits.

To administer the Chymotrypsin Injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously, ensuring the entire medication is delivered before withdrawing the needle.

Following are the conditions when Chymotrypsin Injection should not be used:

• Not recommended for individuals with a known hypersensitivity or allergy to Chymotrypsin or other related enzymes.
• Contraindicated in patients with acute pancreatitis, as it may exacerbate the condition.
• Avoid using in patients with untreated blood clotting disorders.
• Should not be administered to patients with known or suspected intestinal blockage.
• Not suitable for individuals with active bleeding or a high risk of bleeding disorders.
• Contraindicated in patients with severe liver impairment or active liver disease.
• Not recommended for patients with a history of or existing thromboembolic disease.

The side effects of Chymotrypsin Injection may include:

• Allergic reactions such as rash, itching, or hives
• Nausea and vomiting
• Diarrhea
• Stomach pain or cramps
• Fever or chills
• Increased heart rate
• Difficulty breathing or swallowing
• Skin irritation or redness at the injection site

Following are the precautions and warnings:

• Chymotrypsin Injection should only be used under medical supervision and is typically administered by healthcare professionals.
• Do not use if you have a known allergy to chymotrypsin or pork-derived products.
• Not recommended for individuals with acute inflammation, acute pancreatitis, or acute hemorrhagic pancreatitis.
• Caution is advised in patients with liver or kidney disease, as dosage adjustments may be necessary.
• Avoid using if you have a history of blood clotting disorders or are taking anticoagulant medications.
• This medication may cause allergic reactions; immediate medical attention should be sought if symptoms such as rash, itching, or difficulty breathing occur.
• Pregnant and breastfeeding women should consult their doctor before using Chymotrypsin Injection, as the risks and benefits should be carefully evaluated.
• Always follow the prescribed dosage and duration of treatment; do not exceed the recommended dose.

Following are the drug interactions for Chymotrypsin Injection:

• Antibiotics like tetracyclines, erythromycin, and aminoglycosides may have reduced absorption when used with Chymotrypsin.
• The effectiveness of oral anticoagulants such as warfarin may be altered, requiring close monitoring of coagulation parameters.
• Chymotrypsin can increase the absorption of certain medications, including digoxin and some heart medications, potentially requiring dosage adjustments.
• Concomitant use with protease inhibitors may lead to decreased effectiveness of both drugs.
• Non-steroidal anti-inflammatory drugs (NSAIDs) might increase the risk of gastrointestinal bleeding when combined with Chymotrypsin.
• The breakdown of some medications, including corticosteroids and estrogens, could be affected by Chymotrypsin, potentially requiring dosage modifications.
• Chymotrypsin may interact with other enzyme-based medications, affecting the activity of both drugs.

Following are the food interactions to consider with Chymotrypsin Injection:

• Avoid high-fat meals as they can potentially delay the absorption of Chymotrypsin, affecting its effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they may alter the enzyme activity and impact the drug's metabolism.
• Alcohol intake should be limited as it can increase the risk of gastrointestinal bleeding, especially when combined with Chymotrypsin's blood-thinning properties.
• Avoid dairy products close to the time of injection as they can potentially reduce the absorption of Chymotrypsin.
• Spicy foods might irritate the digestive tract, especially when dealing with gastrointestinal issues for which Chymotrypsin is prescribed.
• Caffeinated beverages may stimulate gastric acid secretion, potentially reducing the efficacy of Chymotrypsin in treating certain conditions.
• Consuming high-fiber foods might be beneficial as they can aid in digestion and support the overall effectiveness of Chymotrypsin.
• Always follow healthcare provider's advice on dietary adjustments during the treatment period.

Chymotrypsin Injection should be stored with utmost care, ensuring a cool and dry environment, preferably at room temperature, shielded from direct sunlight and moisture. Maintain the integrity of the medication by securely sealing its original container. Avoid storage in bathrooms or proximity to heat sources like stoves, as temperature fluctuations can compromise the drug's efficacy. Prioritize safety by regularly checking the expiration date and responsibly discarding any unused or expired injections; refrain from flushing or pouring them down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods, and keep the medication inaccessible to children to prevent accidental ingestion.

Following are the quick tips for Chymotrypsin Injection:

• Administer the injection as directed by your healthcare professional.
• Ensure the injection is stored at the recommended temperature.
• Check the expiry date before use.
• Use a sterile needle and syringe for each injection.
• Inject the medication slowly as instructed.
• Rotate injection sites to minimize discomfort.
• Report any unusual reactions or side effects promptly.
• Dispose of used needles and syringes safely.