CILAPEN 250MG INJ

Imipemide 250mg injection acts as a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its primary mechanism of action involves inhibiting the cyclooxygenase (COX) enzyme, which plays a key role in the synthesis of prostaglandins. By blocking COX, Imipemide reduces the production of prostaglandins, which are mediators of inflammation, pain, and fever. This inhibition helps alleviate pain, decrease inflammation, and lower elevated body temperature. Imipemide selectively targets the COX enzyme, thereby providing its therapeutic effects without directly affecting other pathways in the body.

Imipemide 250mg

Antiparasitic

Injection

The following are the uses of Imipemide 250mg injection:

• Used for treating severe dehydration and restoring fluid balance in the body.
• Used for managing fluid and electrolyte levels in patients with acute diarrhea.
• Used to prevent and correct low blood volume during surgery.
• Used for rehydration in patients who cannot tolerate oral fluids.
• Used to manage fluid levels in conditions like diabetic ketoacidosis.
• Used to provide rapid fluid replacement in emergency situations.
• Used for maintaining hydration in patients with severe burns or heatstroke.

In the case of an overdose of Imipemide 250mg injection, it is crucial to act swiftly. Symptoms may include severe dizziness, nausea, and potential cardiac issues. Immediate medical attention is necessary, including contacting a poison control center or seeking emergency care. Prompt intervention can help manage symptoms and reduce the risk of serious complications. Always store medications safely and follow dosage instructions to prevent such incidents.

In the case of a missed dose of Imipemide 250mg injection, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen.

To administer Imipemide 250mg injection, prepare the medication by drawing the prescribed dose into a syringe, then inject it intramuscularly or intravenously as directed by your healthcare provider, ensuring proper hygiene and following the recommended dosage guidelines.

Following are the conditions/situations when Imipemide 250mg injection should not be administered:

• Not recommended for individuals with a known allergy or hypersensitivity to Imipemide or other sulfa drugs.
• Contraindicated in patients with severe kidney impairment or kidney failure.
• Should not be used in patients with a history of severe liver disease or liver impairment.
• Not suitable for individuals with a known deficiency of glucose-6-phosphate dehydrogenase (G6PD) as it may cause hemolysis.
• Contraindicated in patients with a history of severe gastrointestinal diseases such as stomach or intestinal bleeding.
• Should be avoided in patients with a history of severe cardiovascular diseases or conditions like heart block.
• Not recommended for individuals with a history of severe respiratory diseases or conditions like asthma.
• Do not administer if the patient has shown previous intolerance or adverse reactions to similar medications.

The side effects of Imipemide 250mg injection may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Dizziness or lightheadedness
• Headache
• Skin rash or itching
• Injection site reactions (such as pain, swelling, or redness)
• Fatigue and weakness

Following are the precautions and warnings for Imipemide 250mg Injection:

• Not recommended for patients with known hypersensitivity to Imipemide or any of its components; severe adverse reactions may occur.
• Renal function should be monitored regularly during treatment, especially in patients with pre-existing kidney issues.
• Imipemide may cause neurotoxicity, leading to symptoms like confusion, hallucinations, and seizures. Discontinue use if these occur.
• Caution is advised for patients with pre-existing neurological disorders as Imipemide may exacerbate symptoms.
• May cause electrolyte imbalances, particularly hypokalemia and hypomagnesemia. Regular monitoring of electrolyte levels is necessary.
• Should be used with caution in elderly patients as they may be more susceptible to adverse effects.
• Not recommended for pregnant and breastfeeding women unless the potential benefits outweigh the risks.

Following are the drug interactions for Imipemide 250mg injection:

• It may interact with other antiepileptic medications, such as phenytoin and carbamazepine, potentially reducing the effectiveness of either drug.
• Concomitant use with other central nervous system (CNS) depressants like benzodiazepines or opioids can enhance respiratory depression and sedation.
• Imipemide may decrease the effectiveness of hormonal contraceptives, requiring alternative birth control methods.
• Drugs that induce or inhibit liver enzymes (e.g., rifampicin, ketoconazole) may alter Imipemide's metabolism, requiring dosage adjustments.
• Caution is advised when combining with anticoagulants, as it may increase the risk of bleeding.
• It may interact with other medications metabolized by the CYP3A4 enzyme system, potentially affecting drug levels.
• The use of Imipemide with certain antibiotics, such as rifampicin, may reduce the antibiotic's effectiveness.

Following are the food interactions for Imipemide 250mg Injection:

• Avoid consuming grapefruit or grapefruit juice as it may interfere with the medication's metabolism, potentially leading to increased side effects.
• Alcohol intake should be minimized or avoided as it may enhance the sedative effects of Imipemide, causing increased drowsiness and reduced alertness.
• Spicy foods are best avoided as they may exacerbate gastrointestinal side effects such as nausea and stomach discomfort.
• Limit the consumption of fatty or greasy meals as they can delay the absorption of the medication, affecting its effectiveness.
• Avoid caffeine-rich beverages like coffee and energy drinks, as they may interact with Imipemide, leading to increased heart rate and potential cardiac issues.
• Ensure adequate hydration by drinking plenty of water, especially if experiencing nausea or diarrhea as side effects.
• Consult your healthcare provider for personalized advice on dietary restrictions or recommendations during the course of this medication.
• Generally, maintaining a balanced diet and staying well-hydrated can aid in managing side effects and supporting overall health while using Imipemide.

Imipemide 250mg injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20-25°C (68-77°F). Protect the injection from direct sunlight, heat, and moisture, as these factors can degrade its potency. Always keep the medication in its original packaging, ensuring the seal is intact, to maintain sterility. When disposing of unused or expired Imipemide injections, do not throw them into the trash or pour them down the drain. Contact your healthcare provider or pharmacist for guidance on safe disposal methods, as they can advise on local regulations for pharmaceutical waste disposal. It is crucial to keep all medications, including Imipemide injections, securely stored and out of the reach of children to prevent accidental exposure.

Following are the quick tips for Imipemide 250mg injection:

• Administer the injection under medical supervision for proper dosage and administration.
• Ensure the injection is stored at room temperature, away from direct sunlight.
• Verify the expiry date before use and do not use if expired.
• Follow the prescribed dosage and injection schedule provided by your doctor.
• Do not inject if the solution is discolored or contains particles.
• Dispose of used needles and syringes safely in a designated sharps container.
• Inform your doctor if you experience any pain, redness, or swelling at the injection site.
• Report any unusual symptoms or side effects to your healthcare provider promptly.