CILAPEN 500MG IV INJ

Cilastatin in Cilastatin and Imipenem injection works by inhibiting the enzyme dehydropeptidase I (DHP-I), which is primarily found in the kidneys. By blocking DHP-I, Cilastatin prevents the metabolism of Imipenem, allowing it to maintain its antibacterial activity. Imipenem, a beta-lactam antibiotic, exerts its mechanism of action by binding to and inhibiting penicillin-binding proteins (PBPs), which are essential for bacterial cell wall synthesis. This disruption in cell wall formation leads to bacterial cell lysis and death.

Cilastatin, Imipenem

Carbapenem/renal enzyme inhibitor

injection

The following are the uses of Cilastatin, Imipenem injection:

• Used for treating severe infections caused by multiple drug-resistant bacteria, particularly in cases of hospital-acquired infections.
• Used for managing infections in patients with weakened immune systems, such as those with HIV/AIDS or undergoing chemotherapy.
• Used for treating complicated intra-abdominal infections, including peritonitis and abscesses.
• Used for controlling skin and soft tissue infections, including diabetic foot infections.
• Used for treating complicated urinary tract infections, including pyelonephritis.
• Used for surgical prophylaxis to prevent infections during high-risk procedures.
• Used for managing infections in critically ill patients in intensive care units.
• Used for treating infections in patients with limited treatment options due to antibiotic resistance.

To be used as per doctor's advice

In the case of an overdose of Cilastatin and Imipenem injection, the primary concern is the potential for severe gastrointestinal disturbances. These may include intense and prolonged nausea, vomiting, and diarrhea. Additionally, an overdose can lead to neurological symptoms such as seizures, confusion, and in extreme cases, coma. It is crucial to seek medical assistance promptly to manage these adverse effects and prevent further complications.

In the case of a missed dose of Cilastatin and Imipenem injection, it is essential to administer the missed dose as soon as possible. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, it is best to consult your healthcare provider for guidance on how to manage your medication schedule effectively.

To administer the Cilastatin and Imipenem injection, mix the contents of the vial with the provided sterile diluent, gently swirl to dissolve, and then inject the entire solution slowly into the muscle or intravenous line as directed by your healthcare professional, ensuring the injection is given at the recommended dosage and frequency prescribed by your doctor.

Following are the conditions or circumstances when Cilastatin, Imipenem injection should not be administered:

• Must not be used in individuals with a history of allergic reactions to Imipenem, Cilastatin, or other related penicillins or carbapenems.
• Contraindicated in patients with a known hypersensitivity to any of the excipients or ingredients in the injection formulation.
• Should not be used in patients with a history of seizures or conditions that lower the seizure threshold, as it may increase the risk of convulsions.
• Not recommended for individuals with severe kidney impairment or kidney failure, as dosage adjustments may not be sufficient to ensure safety.
• Should not be administered to patients with a history of Clostridium difficile-associated diarrhea or antibiotic-associated colitis.
• Contraindicated in patients with a history of anaphylaxis or severe allergic reactions to any medication.
• Not suitable for use in patients with a known or suspected infection caused by microorganisms resistant to Imipenem or Cilastatin.

The side effects of Cilastatin, Imipenem injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Headache
• Dizziness
• Seizures (in rare cases)
• Injection site reactions (pain, redness, swelling)
• Changes in liver function tests

Following are the precautions and warnings for Cilastatin, Imipenem injection:

• This medication should be used with caution in patients with a history of allergic reactions to penicillin or other beta-lactam antibiotics. Severe allergic reactions can occur.
• Regular monitoring of kidney function is necessary during treatment, especially in patients with pre-existing kidney issues.
• Cilastatin, Imipenem injection can cause seizures. Patients with a history of seizures or other neurological disorders should be closely monitored.
• Not recommended for patients with a history of severe gastrointestinal diseases, as it may exacerbate these conditions.
• May cause diarrhea, which can be severe. If persistent diarrhea occurs, patients should seek medical advice immediately.
• Elderly patients may be more susceptible to the side effects of this medication, particularly neurological and gastrointestinal effects.
• Pregnant and breastfeeding women should use this medication only if the potential benefits outweigh the risks, as it can pass into breast milk.

Following are the drug interactions for Cilastatin, Imipenem injection:

• Probenecid, a drug used to treat gout, can decrease the elimination of imipenem, leading to increased blood levels of the antibiotic.
• Cilastatin, Imipenem may reduce the effectiveness of oral contraceptives, so alternative birth control methods are recommended during treatment.
• The combination with valproic acid, an anticonvulsant, can increase the risk of seizures.
• It may decrease the effectiveness of methotrexate, a chemotherapy drug, by reducing its renal elimination.
• Neuromuscular blocking agents, such as vecuronium, may have enhanced effects when used with Cilastatin, Imipenem.
• Warfarin, an anticoagulant, may have its effect potentiated, requiring close monitoring of coagulation parameters.
• Drugs that affect renal function, such as diuretics, can alter the elimination of imipenem and should be used with caution.

Following are the food interactions for Cilastatin, Imipenem injection:

• Avoid consuming alcohol during the treatment, as it may increase the risk of seizures and central nervous system side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can alter the effectiveness of the medication by affecting the enzymes responsible for drug metabolism.
• High-fiber foods like whole grains, legumes, and vegetables are recommended to promote healthy gut bacteria and prevent gastrointestinal issues.
• Probiotics found in yogurt, kefir, and fermented foods can help maintain a healthy gut microbiome, which is beneficial during antibiotic treatment.
• Avoid high-sodium foods as they may interact with Cilastatin, affecting its ability to block the breakdown of Imipenem.
• Consume a balanced diet to ensure adequate nutrition and support the body's immune system during the course of treatment.
• Stay well-hydrated by drinking plenty of fluids, especially water, to aid in the elimination of the medication and maintain kidney health.
• Avoid consuming foods or drinks with high sugar content, as they can impact the balance of bacteria in the gut and potentially reduce the effectiveness of the medication.

Cilastatin, Imipenem injection should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F). Protect the injection from direct sunlight and avoid freezing or excessive heat. Always keep the medication in its original packaging, ensuring the vial or ampoule is intact and sealed. Dispose of any unused or expired medication properly, following local guidelines for pharmaceutical waste disposal. Do not attempt to reuse or recycle the injection materials, as this may pose health risks. It is crucial to keep the medication away from children and pets to prevent accidental exposure or ingestion. Healthcare professionals should handle the disposal process according to established safety protocols.

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Following are the quick tips for Cilastatin, Imipenem injection:

• Administer the injection as directed by your healthcare professional for optimal therapeutic effect.
• Ensure the injection is prepared and administered by trained medical staff.
• Follow the prescribed dosage and administration schedule for the best outcome.
• Inform your doctor if you have kidney or liver problems to ensure safe usage.
• Do not use if you are allergic to any of its components; inform your doctor of all allergies.
• Store the medication as directed on the packaging, away from light and moisture.
• Do not reuse needles, syringes, or other injection materials; dispose of them safely.