Cilosta (100mg) 30 Tablets

Cilostazol's primary mechanism of action involves inhibiting phosphodiesterase type 3 (PDE3), an enzyme that breaks down cyclic adenosine monophosphate (cAMP). By blocking PDE3, cilostazol increases intracellular cAMP levels, leading to various effects on platelets and blood vessels. It inhibits platelet aggregation by reducing the release of adenosine diphosphate (ADP) and thromboxane A2, which helps prevent excessive blood clotting. Additionally, cilostazol promotes vasodilation by relaxing vascular smooth muscle cells, improving blood flow and reducing vascular resistance. This dual action contributes to its therapeutic benefits in managing peripheral vascular diseases and intermittent claudication.

Cilostazol 100mg

Phosphodiesterase-3 inhibitor.

Tablet

The following are the uses of Cilostazol 100mg Tablet:

• Used for improving blood flow in patients with peripheral vascular disease, reducing symptoms like leg pain during walking.
• Used for treating intermittent claudication, allowing for increased walking distance.
• Used to prevent blood clots, particularly in individuals with a history of stroke or heart disease.
• Used for managing symptoms of poor circulation, including leg cramps and cold feet.
• Used to reduce the risk of recurrent strokes or heart attacks in certain patients.
• Used for enhancing blood circulation in the legs, improving overall mobility.
• Used as a secondary prevention strategy for vascular events in high-risk individuals.

In the case of an overdose of Cilostazol 100mg Tablets, it is important to recognize the potential symptoms, which may include severe headaches, dizziness, and an irregular heartbeat. Prompt action is necessary; contact a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the individual's condition and the amount ingested. Quick response and appropriate medical care are vital in managing the potential risks associated with a Cilostazol overdose.

In the case of a missed dose of Cilostazol 100mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you have missed multiple doses, consult your healthcare professional for advice on how to safely resume your medication regimen without affecting the treatment's efficacy.

To take Cilostazol 100mg Tablet, swallow the tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, usually twice a day, with a 12-hour interval between doses.

Following are the conditions or circumstances when Cilostazol 100mg Tablet should not be taken:

• Must not be used in individuals with a known allergy to Cilostazol or other phosphodiesterase inhibitors.
• Not suitable for individuals with severe liver or kidney disease.
• Contraindicated in patients with severe heart failure.
• Should not be used if you have a history of heart attack or unstable angina.
• Avoid using this medication if you have recently had a stroke or transient ischemic attack (TIA).
• Not recommended for individuals with bleeding disorders or a history of bleeding in the brain.
• Must not be taken if you have uncontrolled high or low blood pressure.
• Contraindicated during pregnancy and breastfeeding.
• Avoid using this medication if you have a scheduled surgery or major dental work.

The side effects of Cilostazol 100mg Tablet may include:

• Headache
• Diarrhea
• Dizziness
• Nausea and/or vomiting
• Excessive bleeding (e.g., nosebleeds, bleeding gums)
• Palpitations or increased heart rate
• Muscle pain or weakness
• Skin rashes or itching

Following are the precautions and warnings for Cilostazol 100mg Tablet:

• This medication should not be taken by individuals with known allergies to Cilostazol or any of its inactive ingredients.
• Patients with a history of heart failure, arrhythmias, or recent heart attack should use Cilostazol with caution and under medical supervision.
• It may increase the risk of bleeding, so those with bleeding disorders or taking anticoagulant medications should exercise caution.
• Cilostazol can cause dizziness and headache; patients should be cautious until they know how the medication affects them.
• Not recommended for individuals with severe liver disease, as it may worsen their condition.
• Should be used with caution in elderly patients as they may be more susceptible to side effects.
• Pregnant and breastfeeding women should consult their doctor before taking Cilostazol, as it may pose risks to the fetus or infant.

Following are the drug interactions for Cilostazol 100mg Tablet:

• Strong inhibitors of CYP3A4 and CYP2C19 (e.g., ketoconazole, clarithromycin) can increase Cilostazol levels, potentially requiring a dose adjustment.
• Cilostazol may increase the effects of anticoagulants like warfarin, necessitating closer monitoring of INR values.
• Concomitant use with other antiplatelet agents (e.g., aspirin, clopidogrel) can increase the risk of bleeding.
• Cilostazol may enhance the effects of antihypertensive medications, leading to a more pronounced drop in blood pressure.
• Grapefruit juice should be avoided as it can increase Cilostazol levels, possibly requiring dose adjustments.
• The combination with strong CYP3A4 inducers (e.g., rifampin) may decrease Cilostazol's effectiveness.
• Cilostazol may interact with certain anti-seizure medications, affecting their blood levels.

Following are the food interactions for Cilostazol 100mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase the levels of Cilostazol in the blood, potentially leading to an increased risk of side effects.
• Alcohol intake is not recommended with Cilostazol as it may enhance the risk of bleeding and gastrointestinal issues.
• Foods rich in caffeine, such as coffee, tea, and energy drinks, should be limited as they may interact with Cilostazol, affecting blood vessel function.
• Avoid eating large amounts of high-fat meals as they can alter the absorption of Cilostazol, potentially reducing its effectiveness.
• Cilostazol may interact with certain herbal supplements, particularly those that affect blood clotting, such as ginkgo biloba and garlic supplements.
• Consuming a balanced diet rich in fruits, vegetables, and whole grains is generally recommended to support overall health while taking Cilostazol.
• Avoid excessive salt intake, as it can counteract the effects of Cilostazol on blood pressure.
• It's advisable to maintain a consistent diet and avoid sudden dietary changes while on Cilostazol therapy.

Cilostazol 100mg Tablets should be stored in a secure and dry location, away from direct sunlight and moisture. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to contaminants. Avoid placing the medication in areas prone to temperature fluctuations, such as the bathroom, kitchen, or near heating devices, as this can impact its effectiveness. Regularly check the expiration date on the packaging, and properly dispose of any unused or expired tablets. Do not dispose of them by flushing or pouring them into water sources; instead, consult your pharmacist or healthcare professional for appropriate disposal guidelines. Additionally, ensure that the medication is stored out of children's reach to prevent accidental consumption.

Following are the quick tips for Cilostazol 100mg Tablet:

• Start with a lower dose and gradually increase as directed by your doctor to minimize side effects.
• Take the tablet with or after meals to reduce stomach-related issues.
• Avoid crushing or chewing the tablet; swallow it whole with a full glass of water.
• Maintain a consistent schedule for taking the medication for best results.
• Inform your doctor if you have any bleeding disorders or upcoming surgeries.
• Do not abruptly stop the medication; consult your doctor for a proper tapering schedule.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.