CINIPRIDE SYP 60ML

Cinitapride primarily acts as a selective serotonin 5-HT4 receptor agonist and a dopamine D2 receptor antagonist. It stimulates the release of acetylcholine, which enhances gastrointestinal motility and accelerates gastric emptying. As a prokinetic agent, cinitapride increases the contractility of the gastrointestinal smooth muscles, particularly in the stomach and small intestine, promoting the movement of food through the digestive tract. This mechanism helps in the treatment of gastrointestinal disorders related to motility issues.

Cinitapride

Prokinetic agent

Suspension

The following are the uses of Cinitapride Syrup/Suspension:

• Used for treating gastroesophageal reflux disease (GERD) in children
• Used to improve gastrointestinal motility and reduce symptoms of indigestion
• Used for the management of functional dyspepsia in pediatric patients
• Used to relieve symptoms of nausea and vomiting associated with digestive issues
• Used to treat gastrointestinal disorders like gastroparesis, improving stomach emptying
• Used to alleviate abdominal pain and discomfort in children with gastrointestinal problems
• Used for promoting appetite and weight gain in children with poor feeding or growth issues

In the case of an overdose of Cinitapride Syrup/Suspension, individuals may experience symptoms such as severe dizziness, fainting, rapid heart rate, and in some cases, seizures. It is important to seek medical assistance promptly if an overdose is suspected. Treatment may involve managing the symptoms and providing supportive care. If ingestion is recent, healthcare professionals might induce vomiting or perform gastric lavage to remove the excess medication from the stomach.

In the case of a missed dose of Cinitapride Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to remind you to take your medication at the prescribed times. It's important to maintain consistency with this medication for optimal effectiveness.

To administer Cinitapride Syrup/Suspension, shake the bottle vigorously, then measure the prescribed dosage using an appropriate measuring device like a dosing spoon or oral syringe, and take it orally, either with or without food, as directed by your healthcare professional or as indicated on the medication label.

Following are the conditions/situations when Cinitapride Syrup/Suspension should not be used:

• Should not be administered to infants under 6 months of age.
• Contraindicated in individuals with a known allergy or hypersensitivity to cinitapride or any of its excipients.
• Not recommended for patients with a history of long QT syndrome or other cardiac conduction disorders.
• Avoid use in patients with severe hepatic impairment.
• Not suitable for individuals with gastrointestinal bleeding or obstruction.
• Should be used with caution and avoided in patients with severe renal impairment.
• Contraindicated during breastfeeding as it may pass into breast milk.
• Not recommended for patients with a history of seizures or epilepsy.

The side effects of Cinitapride Syrup/Suspension may include:

• Diarrhea
• Headache
• Dizziness
• Dry mouth
• Nausea
• Insomnia
• Constipation
• Abdominal pain

Following are the precautions and warnings for Cinitapride Syrup/Suspension:

• Do not use in patients with known hypersensitivity or allergy to Cinitapride or other related compounds.
• Cinitapride should be used with caution in patients with liver or kidney disease, as it is primarily metabolized in the liver and excreted by the kidneys.
• This medication may cause dizziness or drowsiness, so patients should avoid driving or operating heavy machinery until they know how it affects them.
• Alcohol consumption should be avoided as it may increase the risk of adverse effects.
• Cinitapride may interact with other medications, so patients should inform their healthcare provider of all medications they are currently taking.
• Not recommended for use in children and adolescents under 18 years of age as the safety and efficacy in this age group have not been established.
• Elderly patients may be more sensitive to the effects of Cinitapride, so dosage adjustments might be necessary.

Following are the drug interactions for Cinitapride Syrup/Suspension:

• Cinitapride may interact with other prokinetic agents like metoclopramide, increasing the risk of extrapyramidal side effects.
• The effect of anticoagulants such as warfarin can be enhanced, leading to a higher bleeding risk.
• Concomitant use with digoxin may increase digoxin levels, requiring close monitoring.
• Cinitapride can elevate plasma levels of midazolam and other benzodiazepines, potentially leading to enhanced sedation.
• The absorption of certain antibiotics like erythromycin may be affected, altering their efficacy.
• When combined with antacids, the absorption of cinitapride may be reduced, decreasing its effectiveness.
• Caution is advised when using cinitapride with other medications that prolong QT intervals, as this may increase the risk of cardiac arrhythmias.

Following are the food interactions to consider with Cinitapride Syrup/Suspension:

• Avoid consuming grapefruit or grapefruit juice as they can inhibit the CYP3A4 enzyme, potentially increasing Cinitapride levels in the blood and raising the likelihood of adverse effects.
• Refrain from drinking alcohol as it can enhance the sedative effects, leading to increased dizziness and drowsiness.
• High-fat meals may slightly delay the absorption of Cinitapride, but this typically doesn't affect its overall effectiveness.
• Avoid caffeine-rich beverages like coffee or energy drinks, as Cinitapride can enhance their stimulant effects, causing jitters or an increased heart rate.
• Consuming spicy foods might irritate the gastrointestinal tract, especially if you have a sensitive stomach, potentially worsening any gastrointestinal side effects of Cinitapride.
• Dairy products, particularly milk, can form insoluble complexes with Cinitapride, reducing its absorption. Thus, it's advisable to separate milk consumption from Cinitapride by at least 2 hours.
• Always adhere to the dosing instructions provided by your healthcare professional, as they may have specific recommendations regarding food interactions tailored to your health condition.
• Certain herbal supplements, like St. John's Wort, can interact with Cinitapride, potentially reducing its effectiveness, so it's essential to inform your healthcare provider about any herbal remedies you're taking.

Cinitapride Syrup/Suspension should be stored with caution, ensuring it remains in a cool and dry place, ideally at room temperature, shielded from direct sunlight and moisture. Keep the medication securely sealed in its original container to maintain its integrity and prevent contamination. Avoid bathroom storage or proximity to heat sources like stoves or radiators, as temperature fluctuations can compromise the medicine's effectiveness. Prioritize safety by checking the expiration date before use and disposing of any unused or expired syrup responsibly; refrain from flushing it or pouring it down the drain. Consult your pharmacist for guidance on appropriate disposal methods, and ensure the medication is stored away from children to prevent accidental consumption.

Following are the quick tips for Cinitapride Syrup/Suspension:

• Consult a healthcare professional for dosage instructions based on your medical condition.
• Administer the prescribed amount using the measuring device provided.
• Mix the syrup/suspension well before each use to ensure uniformity.
• Take the medication as directed, typically 15-30 minutes before meals.
• Store in a cool, dry place, away from direct sunlight.
• Do not freeze the medication.
• Keep the medication out of children's reach to prevent accidental consumption.
• Regularly monitor and assess treatment effectiveness with your doctor.