Cinoflox (125Mg/5Ml) 60Ml Suspension

Ciprofloxacin 125mg Syrup/Suspension works by inhibiting bacterial DNA gyrase, a type II topoisomerase enzyme essential for bacterial DNA replication, transcription, and repair. It binds to the A subunit of DNA gyrase, preventing the enzyme from relaxing supercoiled DNA and leading to the accumulation of double-stranded DNA breaks. This interference with DNA synthesis and repair is bactericidal, primarily targeting bacterial DNA replication and cell division. Ciprofloxacin is particularly effective against a broad spectrum of gram-negative and gram-positive bacteria, making it a potent antibiotic for various infections.

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Fluoroquinolone antibiotic.

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Suspension

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The following are the uses of Ciprofloxacin 125mg Syrup/Suspension:

• Used for treating bacterial infections in children, especially those affecting the respiratory tract, urinary tract, and gastrointestinal system.
• Used for controlling the spread of bacterial infections in children, helping to alleviate symptoms and prevent further complications.
• Used for managing certain types of diarrhea caused by bacterial infections, helping to restore normal intestinal function.
• Used for treating skin and soft tissue infections, promoting healing and preventing the spread of infection.
• Used for controlling bacterial growth in specific conditions like cystic fibrosis, where it helps manage respiratory infections.
• Used for its broad-spectrum activity against various bacteria, making it effective in treating multiple types of infections.
• Used for its ability to penetrate well into different body tissues, ensuring effective treatment of infections.
• Used for its safety and tolerability in children, providing an effective treatment option with minimal side effects.

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Dose must be taken according to doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. 1 leveled teaspoon is equal to 5ml, and each 5ml of this suspension after reconstitution contains 125mg. So calculate your dose accordingly. Adult dose: For acute sinusitis: 500mg orally after every 12 hours for 10 days. For mild to moderate bone & joint infections: 500mg orally after every 12 for ≥4-6 weeks For severe bone & joint infections: 750mg orally after every 12 hours for ≥4-6 weeks. For chronic bacterial prostatitis: 500mg orally after every 12 hours for 28 days. For infectious diarrhea: 500mg orally after every 12 hours for 5-7 days. For complicated intra-abdominal infections: 500mg orally after every 12 hours for 7-14 days. For mild to moderate lower respiratory tract infections: 500mg orally after every 12 hours. For severe to complicated lower respiratory tract infections: 750mg orally after every 12 for 7-14 days. For mild to moderate skin infections: 500mg orally after every 12 hours for 7-14 days. For severe to complicated skin infections: 750mg orally after every 12hr for 7-14 days. For acute and uncomplicated urinary tract infections: Immediate-release tablets/capsules, 250mg orally after every 12 hours for 3 days; extended-release tablets/capsules, 500mg orally after every 24 hours for 3 days. For mild to moderate urinary tract infections: 250mg orally after every 12 hours for 7-14 days. For severe or complicated urinary tract infections: 500mg orally after every 12 hours for 7-14 days. For urethral & cervical gonococcal infections: 250-500mg once orally. For anthrax infection: 500mg orally after every 12 hours for 60 days. For plague: 500-750mg orally after every 12 hours for 14 days. Child dose: For urinary tract infections including kidney infections: In children of age 1 to 17 years; 10mg/kg to 20mg/kg (maximum of 750mg per dose) orally every 12 hours for 10 to 21 days. For prevention of anthrax infection after exposure in children from birth to 17 years; 15mg/kg (max 500mg per dose) every 12 hours for 60 days. For Plague from birth to 17 years: 15mg/kg (maximum of 500mg per dose) every 8 to 12 hours for 14 days.

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In the case of an overdose of Ciprofloxacin 125mg Syrup/Suspension, several symptoms may occur, including nausea, vomiting, diarrhea, and dizziness. It is important to seek medical advice immediately and provide information about the quantity ingested. Treatment for overdose may involve supportive measures such as fluid replacement and monitoring of vital signs. Prompt medical intervention can help manage potential adverse effects and ensure the patient's well-being.

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In the case of a missed dose of Ciprofloxacin 125mg Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is best to take the medication at evenly spaced intervals to maintain a consistent level in your system. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

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To administer Ciprofloxacin 125mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with an oral syringe or measuring cup, and give it to your child by mouth, ensuring they swallow it completely; follow the dosage instructions provided by your healthcare professional, typically given twice a day, 12 hours apart, with or without food.

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Following are the conditions/situations when Ciprofloxacin 125mg Syrup/Suspension should not be taken:

• Should not be used in individuals with a known allergy to Ciprofloxacin or other quinolone antibiotics.
• Contraindicated in patients with a history of tendon disorders or tendon rupture related to previous quinolone use.
• Not suitable for individuals with myasthenia gravis, as it can worsen muscle weakness.
• Should be avoided in patients with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Contraindicated in patients with prolonged QT intervals or known heart rhythm disorders.
• Not recommended for children and adolescents under 18 years of age, as it may affect growing bones and joints.
• Should not be used in individuals with a history of liver disease or impaired liver function.
• Avoid in patients with kidney disease or those on dialysis, as dosage adjustment is necessary.

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The side effects of Ciprofloxacin 125mg Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Skin rash or itching
• Central Nervous System (CNS) effects like confusion, tremors, or seizures.
• Sensitivity to sunlight (photosensitivity)

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Here are the precautions and warnings for Ciprofloxacin 125mg Syrup/Suspension:

• Ciprofloxacin should not be used in patients with a known allergy to fluoroquinolone antibiotics or any of the excipients in the syrup.
• This medication can cause serious adverse reactions, including tendonitis and tendon rupture, especially in older patients. Discontinue use and seek medical attention if tendon pain or swelling occurs.
• It may cause central nervous system effects like dizziness and lightheadedness. Patients should avoid driving or operating machinery until they know how the medication affects them.
• Ciprofloxacin can lower the seizure threshold, so caution is advised in patients with a history of seizures or conditions that increase seizure risk.
• The syrup may contain sugar, which should be considered in patients with diabetes or those on a sugar-restricted diet.
• Avoid exposure to direct sunlight or UV rays while taking Ciprofloxacin, as it may increase sensitivity to sunlight.
• Pregnant and breastfeeding women should consult their healthcare provider before taking this medication, as it may cause harm to the fetus or infant.
• Store the medication at room temperature, away from moisture and light, and keep it out of reach of children.

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Following are the drug interactions for Ciprofloxacin 125mg Syrup/Suspension:

• Theophylline levels may be increased, leading to potential toxicity.
• May reduce the effectiveness of phenytoin, carbamazepine, and methotrexate.
• Can enhance the effects of oral anticoagulants, requiring close monitoring of coagulation parameters.
• May increase the risk of adverse effects when combined with non-steroidal anti-inflammatory drugs (NSAIDs).
• Probenecid can decrease the renal excretion of ciprofloxacin, resulting in higher serum levels.
• Ciprofloxacin may decrease the effectiveness of live vaccines (e.g., typhoid vaccine).
• Concomitant use with tizanidine can cause increased tizanidine plasma concentrations, leading to potential side effects.
• May interfere with the metabolism of caffeine, leading to reduced clearance and increased caffeine-related side effects.

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Following are the food interactions for Ciprofloxacin 125mg Syrup/Suspension:

• Dairy products like milk, yogurt, cheese should be avoided as they can reduce the absorption of Ciprofloxacin, decreasing its effectiveness.
• Caffeine intake should be limited as it can increase the side effects of Ciprofloxacin, especially nervousness and insomnia.
• Avoid alcohol consumption as it can increase the risk of liver toxicity and may also intensify the side effects such as dizziness and lightheadedness.
• Grapefruit and grapefruit juice are to be avoided as they can affect the metabolism of Ciprofloxacin, leading to increased levels in the body and potential side effects.
• Consume a balanced diet rich in fiber to prevent gastrointestinal issues that may be associated with antibiotic use.
• Stay hydrated by drinking plenty of water to maintain kidney function and reduce the risk of kidney-related side effects.
• Avoid high-sugar foods and beverages as they can promote the growth of certain bacteria, potentially reducing the effectiveness of the medication.

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Ciprofloxacin 125mg Syrup/Suspension should be stored in a secure location, away from direct sunlight, heat, and moisture. Maintain a consistent room temperature, ensuring the medication remains stable. Keep the syrup in its original container, tightly sealed, to prevent contamination. It is crucial to check the expiration date regularly and dispose of any unused or expired medication promptly. When disposing of the syrup, avoid flushing it down the toilet or drains; instead, seek advice from a pharmacist or healthcare professional for appropriate disposal methods. Remember to store the medication safely, out of the reach of children, to prevent accidental consumption.

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Following are the quick tips for Ciprofloxacin 125mg Syrup/Suspension:

• Always follow your doctor's prescription for dosage and duration.
• Administer the syrup/suspension with a measuring device provided to ensure accurate dosing.
• Shake the bottle well before each use to ensure proper medication distribution.
• Give the medication at evenly spaced intervals to maintain a consistent level in the body.
• Encourage your child to drink plenty of fluids while taking this medication.
• Store the syrup/suspension in a cool, dry place, away from direct sunlight.
• Do not use if the syrup/suspension has changed color or developed an unusual odor.
• Contact your healthcare provider if your child's symptoms persist or worsen.

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To scan for bacterial infection, go for; Blood Culture Test. To monitor organs performance before and with the use of this drug, go for the following tests: For liver; LFT, Ultrasound. For kidney; Renal Function Test, Ultrasound. For heart: ECG.

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