CISPLATIN 50MG 50ML DBL

Cisplatin's mechanism of action primarily involves DNA damage and subsequent cell death. It enters cells and reacts with water to form reactive species that can bind to the nitrogen atoms in DNA bases, particularly guanine. This leads to the formation of intra-strand and inter-strand DNA cross-links, which block DNA replication and transcription. The DNA damage induced by cisplatin triggers cellular signaling pathways, including the activation of DNA damage response and repair mechanisms. If the damage is extensive and not adequately repaired, it can lead to cell cycle arrest and the activation of apoptosis, resulting in the death of rapidly dividing cells, such as cancer cells. This mechanism makes cisplatin an effective chemotherapeutic agent, as it targets and kills cancer cells by interfering with their DNA replication and survival processes.

cisplatin 50MG

Platinum-based antineoplastic agent.

Infusion

The following are the uses of cisplatin 50MG Infusion:

• Used for treating advanced testicular cancer, often in combination with other chemotherapy drugs.
• Used for effectively shrinking tumors in testicular cancer patients.
• Used for curing certain types of ovarian and bladder cancers, improving survival rates.
• Used for slowing down the growth of cancer cells by damaging their DNA.
• Used for preventing cancer cells from replicating, leading to tumor reduction.
• Used for managing metastatic (advanced) cancers as part of a comprehensive treatment plan.
• Used for inducing remission in some cancer cases, allowing for potential curative surgeries.
• Used for increasing overall survival and improving quality of life in specific cancer diagnoses.

In the case of an overdose of cisplatin 50MG Infusion, prompt medical intervention is necessary. Symptoms may include severe nausea, vomiting, kidney damage, and hearing loss. Medical professionals should closely monitor the patient's vital signs and administer appropriate supportive care. Treatment focuses on managing symptoms and preventing further complications, such as administering antiemetics for nausea and ensuring adequate hydration to protect kidney function. Timely medical care is vital to mitigate the risks associated with cisplatin overdose.

In the case of a missed dose of cisplatin 50MG Infusion, it is important to consult your healthcare provider as soon as possible. They will provide guidance on how to proceed with the missed dose. Generally, it is recommended to administer the missed dose as soon as you remember, but if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one unless advised by your doctor.

To administer the Cisplatin 50MG Infusion, prepare the solution by diluting the contents with a suitable intravenous fluid and administer the infusion slowly over a period of 6 to 8 hours, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Cisplatin 50MG Infusion should not be administered:

• Must not be used in patients with a known allergy to Cisplatin or other platinum-containing compounds.
• Contraindicated in patients with severe kidney disease or impaired kidney function.
• Not suitable for individuals with hearing loss or severe hearing impairment.
• Should not be used in patients with severe bone marrow depression or low blood cell counts.
• Contraindicated during pregnancy as it may cause harm to the fetus.
• Avoid use in patients with a history of seizures or nervous system disorders.

The side effects of Cisplatin 50MG Infusion may include:

• Nausea and vomiting
• Diarrhea
• Loss of appetite
• Fatigue and weakness
• Hearing impairment (ringing in the ears or hearing loss)
• Kidney damage, indicated by changes in urination patterns
• Neuropathy (nerve damage) causing numbness or tingling sensations
• Low blood cell counts, which can increase the risk of infection, anemia, and bleeding.

Following are the precautions and warnings for Cisplatin 50MG Infusion:

• This medication is intended for intravenous use only under the supervision of a healthcare professional.
• Patients should be adequately hydrated before and during treatment to reduce the risk of kidney damage.
• Regular monitoring of kidney function and hearing tests are essential during treatment, as cisplatin can cause kidney damage and hearing loss.
• Not recommended for patients with pre-existing hearing impairment or kidney disease; these conditions may worsen with cisplatin use.
• Cisplatin can cause severe nausea and vomiting; antiemetic medication may be prescribed to manage these side effects.
• Blood tests are necessary to monitor blood cell counts, as cisplatin can affect bone marrow function.
• Patients should inform their doctor about all medications they are taking, especially other chemotherapy drugs, to avoid potential interactions.
• Cisplatin may cause neurological side effects; patients should report any symptoms like numbness, tingling, or seizures immediately.

Following are the drug interactions for Cisplatin 50MG Infusion:

• Concomitant use with aminoglycoside antibiotics (e.g., gentamicin) can increase the risk of hearing loss and kidney damage.
• Cisplatin may reduce the effectiveness of myelosuppressive medications, such as cyclophosphamide, due to its own myelosuppressive effects.
• The nephrotoxicity of cisplatin can be enhanced when used with other nephrotoxic drugs like furosemide, increasing the risk of kidney injury.
• It may interact with diuretics, causing electrolyte imbalances, particularly hypomagnesemia.
• Concomitant use with other ototoxic medications (e.g., vancomycin) may increase the risk of hearing impairment.
• Cisplatin can increase the risk of bleeding when used with anticoagulants, such as heparin.
• The toxicity of cisplatin may be increased when combined with other platinum-based chemotherapy agents, potentially leading to severe side effects.

Following are the food interactions for Cisplatin 50MG Infusion:

• Avoid consuming grapefruit and grapefruit juice as they can decrease the elimination of cisplatin, leading to increased levels in the body and potential toxicity.
• Alcohol consumption should be minimized or avoided as it can enhance the risk of kidney damage and hearing impairment associated with cisplatin treatment.
• High-sodium foods should be limited as cisplatin can cause sodium retention, leading to fluid retention and increased blood pressure.
• Restrict foods rich in potassium, such as bananas, oranges, and spinach, as cisplatin can cause potassium imbalances.
• Avoid foods high in phosphorus, like dairy products and nuts, as cisplatin may affect phosphorus levels.
• Ensure adequate hydration before and after treatment to reduce the risk of dehydration and kidney damage.
• Follow a balanced diet recommended by your healthcare provider to maintain nutrition and support recovery during treatment.
• Consider dietary adjustments to manage taste changes and nausea, which are common side effects of cisplatin.

Cisplatin 50MG Infusion should be stored in a secure and controlled environment, specifically in a cool, dry place with a temperature range between 15-25°C (59-77°F). It is crucial to protect the infusion from light and moisture, so storing it in its original packaging or a light-resistant container is recommended. Always check the expiration date, and do not use the medication if it is past its expiry. When disposing of cisplatin, it should be treated as a hazardous waste. Do not dispose of it in regular household trash or pour it down the drain. Contact your healthcare provider or local waste management authorities for guidance on proper disposal methods to ensure it is handled and discarded safely, adhering to environmental regulations. Keep this medication securely locked away from children and pets to prevent accidental exposure.

Following are the quick tips for Cisplatin 50MG Infusion:

• Administer under medical supervision; do not self-administer.
• Ensure accurate dosage calculation based on body surface area.
• Infuse over a specified duration; do not rush the process.
• Use only sterile equipment and solutions for preparation.
• Monitor vital signs and kidney function during and after infusion.
• Stay hydrated and maintain good oral hygiene during treatment.
• Report any unusual symptoms or side effects promptly.