Clarinase 14 Tablets

Pseudoephedrine and Loratadine are the active ingredients in the tablet, each with distinct mechanisms of action. Pseudoephedrine primarily acts as a sympathomimetic amine, stimulating alpha-adrenergic receptors in the respiratory tract, leading to vasoconstriction and reduced congestion. This action helps to relieve nasal and sinus congestion by shrinking swollen blood vessels and allowing for easier breathing. Loratadine, on the other hand, is a potent second-generation antihistamine that selectively blocks peripheral histamine H1 receptors. By inhibiting these receptors, Loratadine effectively reduces allergic responses, alleviating symptoms such as sneezing, itching, and runny nose, without causing significant drowsiness associated with some other antihistamines.

Antihistamine, decongestant

Tablet

The following are the uses of Pseudoephedrine, Loratadine 10mg Tablet:

• Used for temporarily relieving nasal congestion due to the common cold, hay fever, or other upper respiratory allergies.
• Used for reducing sinus congestion and pressure.
• Used to promote sinus drainage, providing relief from sinus headaches.
• Used for treating symptoms such as a runny nose, sneezing, and watery eyes.
• Used for addressing congestion in the ears, helping to alleviate ear discomfort.
• Used for easing breathing by reducing swelling in the nasal passages.
• Used as a short-term treatment for congestion-related symptoms.

In the case of an overdose of Pseudoephedrine or Loratadine 10mg tablets, it is important to recognize the potential severity of the situation. Symptoms may include rapid heartbeat, dizziness, and severe drowsiness. If an overdose is suspected, seek medical advice promptly. Treatment may involve supportive care and managing the symptoms to prevent further complications. It is crucial to act quickly and ensure the individual receives appropriate medical attention.

In the case of a missed dose of Pseudoephedrine, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For Loratadine 10mg tablets, if you miss a dose, take it as soon as you remember, but if it's close to your next dose, skip the missed dose and resume your regular dosing schedule. It's important not to take extra medication to compensate for a missed dose.

To take Pseudoephedrine and Loratadine 10mg tablets, swallow the tablets whole with a full glass of water, as directed by your healthcare provider, typically once or twice a day, without crushing or chewing the medication, and it can be taken with or without food.

Following are the conditions/situations when Pseudoephedrine and Loratadine 10mg Tablet should not be used:

• Not recommended for individuals with severe cardiovascular disease, including uncontrolled high blood pressure, recent heart attack, or severe coronary artery disease.
• Should not be used in patients with narrow-angle glaucoma.
• Contraindicated in individuals with severe kidney disease or end-stage renal disease.
• Avoid using in patients with diabetes, especially those with diabetes-related complications.
• Not suitable for individuals with a known allergy to pseudoephedrine, loratadine, or any other similar antihistamines.
• Should not be used in patients with severe liver impairment.
• Contraindicated during breastfeeding, as both drugs may pass into breast milk.
• Not recommended for children below a certain age (age limit may vary depending on the country's guidelines).
• Avoid using in patients with urinary retention or difficulty urinating.
• Should not be combined with certain medications, such as monoamine oxidase inhibitors (MAOIs) or other sympathomimetic drugs.

The side effects of Pseudoephedrine and Loratadine 10mg Tablet may include:

• Headache
• Dizziness
• Nervousness or anxiety
• Insomnia (difficulty sleeping)
• Restlessness or excitability (especially in children)
• Increased heart rate or palpitations
• Dry mouth
• Nausea or stomach upset

Following are the precautions and warnings for Pseudoephedrine, Loratadine 10mg Tablet:

• Individuals with a known allergy to Pseudoephedrine or Loratadine should not take this medication.
• It is crucial to exercise caution in patients with underlying heart conditions, hypertension, or diabetes, as this medication may impact blood pressure and heart rate.
• Avoid consuming alcohol while taking this medication, as it may intensify side effects.
• Do not drive or operate heavy machinery if you experience dizziness or drowsiness after taking this tablet.
• Patients with kidney or liver problems should consult their doctor before use, as dosage adjustments might be necessary.
• Elderly individuals may be more sensitive to the side effects of this medication and should start with a lower dose.
• If symptoms persist or worsen after a few days of treatment, seek medical advice.
• Always inform your healthcare provider about all the medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Pseudoephedrine, Loratadine 10mg Tablet:

• Concomitant use with monoamine oxidase inhibitors (MAOIs), such as phenelzine or tranylcypromine, may cause severe hypertension and life-threatening interactions.
• Other sympathomimetic drugs, including decongestants or stimulants, may increase the risk of elevated blood pressure and heart rate when combined with pseudoephedrine.
• Antihypertensive medications may have reduced effectiveness when combined with pseudoephedrine, as it may increase blood pressure.
• Tricyclic antidepressants (TCAs), such as amitriptyline, may increase the risk of cardiovascular side effects when taken with pseudoephedrine.
• Loratadine may increase the sedative effects of central nervous system depressants, such as alcohol, benzodiazepines, or opioids.
• The combination may cause increased dry mouth, dizziness, or drowsiness, especially in individuals sensitive to antihistamines.
• Liver enzyme inducers, such as rifampin, may decrease the effectiveness of loratadine by increasing its metabolism.
• Antacids or proton pump inhibitors may alter the stomach pH, potentially affecting the absorption of loratadine.

Following are the food interactions for Pseudoephedrine, Loratadine 10mg Tablet:

• Grapefruit and grapefruit juice should be consumed cautiously as they may interfere with the metabolism of Loratadine, potentially leading to increased drug levels and an elevated risk of side effects.
• Alcohol intake is generally safe with this medication, but it's advisable to avoid excessive consumption as it may add to the drowsiness caused by Loratadine.
• Avoid high-fat meals, as they may decrease the absorption and effectiveness of Pseudoephedrine.
• Consuming caffeine-rich foods or beverages with Pseudoephedrine may increase the stimulant effects and the risk of side effects such as increased heart rate and blood pressure.
• It is generally safe to consume this medication with or without food, but always follow the directions provided by your healthcare professional.
• No significant food interactions are known to affect the absorption or efficacy of Loratadine.
• Always ensure you are well-hydrated when taking these medications, especially if you are consuming diuretic foods or beverages.

Pseudoephedrine and Loratadine 10mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and extreme temperatures. It is crucial to keep the tablets in their original packaging or a sealed container to maintain their integrity and prevent contamination. When disposing of unused or expired medication, it is recommended to follow local guidelines or consult a pharmacist. Do not flush the tablets or throw them into the trash without proper precautions. Instead, utilize medication take-back programs or consult healthcare professionals for guidance on safe disposal methods. Ensure that the medication is kept away from children and pets to prevent accidental consumption, as these tablets should be handled with care and stored responsibly.

Following are the quick tips for Pseudoephedrine and Loratadine 10mg Tablet:

• Check the dosage instructions and take as directed for best relief.
• Keep track of your doses to avoid accidental double dosing.
• Stay hydrated and drink plenty of fluids while taking these medications.
• Avoid consuming alcohol as it may intensify side effects.
• Store the medications in a cool, dry place away from direct sunlight.
• Do not share your medication with others, even if their symptoms are similar.
• Consult your pharmacist or healthcare provider if symptoms persist or worsen.