Clenil Aerosol NEBULES 10s

Beclomethasone is a corticosteroid used to manage inflammation, particularly in conditions like asthma and allergic rhinitis. It works by binding to glucocorticoid receptors inside cells, which leads to the suppression of inflammatory mediators and a reduction in the production of pro-inflammatory substances such as cytokines and leukotrienes. This binding also decreases the activity of immune cells involved in inflammation.

Corticosteroid

This aerosol is used for:

• Asthma
• Inflammation
• Airway Swelling
• Mucus Reduction

Beclometasone dosage recommendations are:

• Asthma prophylaxis (Inhalation) - Initially, 100-200 mcg daily for mild cases - 200-400 mcg daily for moderate cases - 400-800 mcg daily for severe cases, given in 2 divided doses. Usual maintenance dose - 400-800 mcg daily in 2 divided doses, titrated to the lowest effective dose. Max - 800 mcg (up to 2 mg may be necessary in severe cases) daily in divided doses. For children ≥6 years - 100 mcg in 2-4 divided doses, titrated to the lowest effective dose for maintenance. Max - 200 mcg daily.
• Allergic and non-allergic rhinitis (Nasal) - 100 mcg into each nostril bid - or 50 mcg in each nostril 3-4 times daily. Max - 400 mcg daily. 50 mcg in each nostril bid may be used as prophylaxis. For children ≥6 years - Same as adult dose.

Seek immediate medical attention if an overdose is suspected. Contact poison control for guidance. Symptoms may include difficulty breathing or throat irritation. Follow medical advice.

Use the missed dose as soon as you remember. If it’s almost time for the next dose, skip the missed dose. Do not double up.

To use Clenil Aerosol Nebules, start by setting up your nebulizer according to the manufacturer's instructions, ensuring that all parts are clean and properly assembled. Open a nebule by twisting or cutting off the top as directed. Squeeze the contents of the nebule into the medication chamber of the nebulizer. Attach the mouthpiece or face mask to the nebulizer and turn on the machine. Breathe in the mist slowly and deeply through the mouthpiece or mask until the medication is fully inhaled, which usually takes about 10-15 minutes. After use, clean the nebulizer parts thoroughly as per the manufacturer's guidelines to prevent buildup and contamination. Store any unused nebules in a cool, dry place, away from light and moisture.

Do not use beclomethasone:

• If you have tubercular or local viral infections.
• If you are hypersensitive to corticosteroids.
• During pregnancy, unless clearly needed.
• While breastfeeding, due to potential risks to the infant

Unraveling the side effects lurking behind this drug product are the following:

• Body aches or pain
• Congestion
• Cough
• Difficulty with breathing
• Dryness or soreness of the throat
• Fever
• Hoarseness
• Runny nose
• Tender, swollen glands in the neck
• Trouble swallowing
• Voice changes

Patients should take into account these precautions and warnings before use:

• Individuals with bacterial infections (such as active or quiescent pulmonary TB), fungal, parasitic, or viral infections (e.g., chickenpox, measles, ocular herpes simplex) should exercise caution.
• Special attention is required for those with diabetes mellitus, gastro-duodenal ulcers, serious arterial hypertension, or myasthenia gravis.
• Patients with a history of myocardial infarction, osteoporosis, hypoadrenalism, glaucoma, cataracts, or seizure disorders should be cautious.
• Those with a history of depression or previous steroid-related psychosis should be particularly careful.
• Care should be taken if there are recent nasal septal ulcers, trauma, or surgery.
• Patients with renal and hepatic impairment, especially those with cirrhosis, need careful monitoring.
• Extra caution is needed when administering to children.
• Pregnancy and lactation require special consideration.

Drug interactions with beclomethasone include:

• CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) (may increase beclomethasone levels, increasing the risk of side effects)
• CYP3A4 inducers (e.g., rifampin) (may decrease beclomethasone levels, reducing efficacy)
• Other corticosteroids (additive effects, increased risk of systemic side effects)
• Immunosuppressants (e.g., cyclosporine) (additive immunosuppressive effects)
• Vaccines (live vaccines may be less effective)
• Antidiabetic agents (may alter glucose metabolism, requiring adjustments)
• Non-steroidal anti-inflammatory drugs (NSAIDs) (increased risk of gastrointestinal irritation)
• Anticoagulants (e.g., warfarin) (may increase bleeding risk)
• Certain diuretics (e.g., thiazides) (may increase risk of hypokalemia)

As of now, there are no known interactions between this drug and food. However, since comprehensive studies on food interactions may not be available, it is advisable to follow general dietary guidelines and consult your healthcare provider or pharmacist if you have any specific concerns or questions.

Beclomethasone should be stored properly to maintain its effectiveness. Store the product at a temperature between 15°C and 30°C in a cool, dry place, away from direct heat, light, and moisture. Ensure the container is tightly closed to prevent contamination. For safety purposes, keep beclomethasone out of reach of children and pets to avoid accidental ingestion. It is advisable to avoid storing the product in humid or warm areas, such as bathrooms or kitchens. If you have any questions or concerns about proper storage, consult your doctor or pharmacist for further guidance to ensure the product’s quality and safety.