CLENIL COMP 50/100MCG INH

Beclomethasone and Salbutamol, when administered as an inhaler, have distinct mechanisms of action. Beclomethasone is a potent glucocorticoid that primarily reduces inflammation in the airways. It binds to glucocorticoid receptors in various cells, particularly in the lungs, and inhibits the production and release of inflammatory mediators such as cytokines and leukotrienes. This action helps decrease airway inflammation, reduce mucus production, and improve lung function. On the other hand, Salbutamol is a short-acting beta-2 adrenergic receptor agonist. It binds to these receptors in the smooth muscle cells of the airways, leading to relaxation of the bronchial smooth muscles. This mechanism provides rapid relief of bronchoconstriction, reduces airway resistance, and improves airflow, thereby alleviating symptoms of asthma and chronic obstructive pulmonary disease (COPD).

Beclomethasone, Salbutamol

Bronchodilator, Corticosteroid

Spray

The following are the uses of Beclomethasone, Salbutamol Spary:

• Used for preventing asthma attacks and managing chronic asthma symptoms.
• Used to reduce inflammation and swelling in the airways.
• Used for quick relief of sudden asthma symptoms and shortness of breath.
• Used to relax and open the airways, making breathing easier.
• Used as a preventative measure before exercise to avoid exercise-induced asthma.
• Used for managing asthma in both adults and children.
• Used as a long-term control medication to reduce asthma flare-ups.

In the case of an overdose of Beclomethasone and Salbutamol Spray, individuals may experience symptoms such as rapid heart rate, tremors, nervousness, and dizziness. These symptoms can vary in intensity depending on the amount of medication inhaled. It is important to seek medical advice if you suspect an overdose, as a healthcare professional can provide guidance on managing the situation effectively and ensure appropriate treatment to alleviate any adverse effects.

In the case of a missed dose of Beclomethasone, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to your next dose, skip the missed dose and continue with your regular dosing schedule. For Salbutamol Spray, if a dose is missed, use it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.

To use the Beclomethasone and Salbutamol inhaler, shake the inhaler well, exhale gently, place the mouthpiece in your mouth, inhale deeply while pressing down on the inhaler, hold your breath for a few seconds, then remove the mouthpiece and breathe out slowly.

Here are the conditions and situations when Beclomethasone and Salbutamol Spray should not be used:

• Should not be used if you are allergic to Beclomethasone, Salbutamol, or any other similar inhaled corticosteroids.
• Not suitable for individuals with a recent history of tuberculosis (TB).
• Contraindicated in patients with untreated fungal, bacterial, or viral infections in the respiratory tract.
• Should not be used to treat an acute asthma attack or bronchospasm.
• Not recommended for individuals with a history of hypersensitivity or severe reactions to similar bronchodilators.
• Avoid using if you have a severe allergy to milk proteins as some formulations may contain lactose.
• Should be used with caution in patients with heart disease, high blood pressure, diabetes, or seizures.
• Not suitable for children under the age of 4 years without medical advice.
• Avoid excessive use, as it may lead to paradoxical bronchospasm (worsening of breathing difficulties).

The side effects of Beclomethasone and Salbutamol Spray may include:

• Throat irritation or dryness
• Cough or hoarseness
• Tremors or shaking (especially in the hands)
• Increased heart rate or palpitations
• Headache or dizziness
• Muscle cramps or joint pain
• Mouth or throat infections
• Bronchospasm (paradoxical bronchoconstriction)

Following are the precautions and warnings for Beclomethasone, Salbutamol Spray:

• Do not use this medication if you are allergic to any of its ingredients, including Beclomethasone and Salbutamol.
• This medication is intended for inhalation only; avoid contact with eyes. Rinse thoroughly with water if eye contact occurs.
• Patients with a history of respiratory infections, heart problems, high blood pressure, or diabetes should use it with caution and under medical supervision.
• Do not exceed the prescribed dosage, as overuse may lead to serious side effects.
• Avoid spraying towards the face or eyes; if accidental contact occurs, immediately flush with water.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before using this medication.
• Keep the spray out of reach of children and pets to prevent accidental ingestion.

Following are the drug interactions for Beclomethasone and Salbutamol Spray:

• Concomitant use with other long-acting beta-agonists (LABAs) or monoamine oxidase inhibitors (MAOIs) is not recommended, as it may lead to cardiovascular effects and increased risk of adverse events.
• Beta-blockers, including eye drops, can reduce the bronchodilator effect of Salbutamol.
• Xanthine derivatives (e.g., theophylline) and steroids (like Beclomethasone) may increase the risk of cardiovascular effects when used with Salbutamol.
• Antihypertensives and diuretics may have their effects reduced by Salbutamol.
• Salbutamol may interact with other sympathomimetic agents, increasing the risk of cardiovascular side effects.
• Tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs) can enhance the cardiovascular side effects of Salbutamol.
• Caution is advised when using Salbutamol with non-potassium-sparing diuretics, as it may lead to hypokalemia.

Following are the food interactions for Beclomethasone, Salbutamol Spray:

• Avoid consuming grapefruit and grapefruit juice as they may influence the drug's metabolism and increase the risk of side effects.
• Alcohol intake should be limited as it can increase the risk of respiratory issues and decrease the effectiveness of the medication.
• Caffeine-rich beverages like coffee and tea might interact, causing increased heart rate and nervousness.
• Avoid high-fat meals as they can decrease the absorption and effectiveness of the medication.
• Spicy foods may potentially trigger coughing or throat irritation when using the spray.
• Dairy products, especially cold ones, can cause throat discomfort and reduce the spray's efficacy.
• Chocolate may interact with the medication, affecting heart rate and sleep patterns.
• Avoid excessive sugar intake as it can impact respiratory health and exacerbate underlying conditions.

Beclomethasone and Salbutamol Spray should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to avoid extreme temperatures, so steer clear of storing it in the bathroom or near heat-emitting appliances. Prior to use, verify the expiration date, and if the medication is past its prime or no longer required, proper disposal is essential. Do not dispose of it in drains or toilets; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Always keep the spray out of children's reach to prevent accidental exposure.

Following are the quick tips for Beclomethasone, Salbutamol Spray:

• Wash your hands before using the spray to maintain hygiene.
• Shake the inhaler well before each use to ensure proper medication delivery.
• Breathe out gently, then place the mouthpiece in your mouth and inhale deeply while pressing down on the canister.
• Hold your breath for a few seconds to allow the medication to reach your lungs effectively.
• Rinse your mouth with water after each use to prevent mouth and throat irritation.
• Keep track of the number of sprays used to know when to refill or replace the inhaler.
• Store the inhaler at room temperature, away from direct sunlight and extreme temperatures.
• Consult your doctor if symptoms worsen or do not improve after using the spray as directed.