Clomfranil (10mg) 100 Tablets

Clomipramine, a medication primarily used in the treatment of obsessive-compulsive disorder (OCD), exerts its therapeutic effects through a specific mechanism of action. It belongs to the class of tricyclic antidepressants (TCAs), but unlike other TCAs, it has a more potent and selective inhibitory effect on the reuptake of serotonin (5-hydroxytryptamine, 5-HT) in the brain. By blocking the serotonin transporter, clomipramine increases the availability of serotonin in the synaptic cleft, enhancing serotonergic neurotransmission. This selective action on serotonin reuptake is believed to underlie its effectiveness in reducing the symptoms of OCD, as serotonin plays a crucial role in regulating mood, anxiety, and compulsive behaviors. The concentration of clomipramine required to inhibit serotonin reuptake is much lower than that needed to affect other neurotransmitter systems, making it particularly effective in targeting the serotonergic system while minimizing effects on other receptors.

Clomipramine 10mg

Tricyclic antidepressant.

Tablet

The following are the uses of Clomipramine 10mg Tablet:

• Used for treating Obsessive-Compulsive Disorder (OCD) to reduce persistent, recurring thoughts and compulsive behaviors.
• Used for managing severe chronic pain, particularly in conditions like fibromyalgia.
• Used for treating panic disorders, helping to control panic attacks and reduce anxiety.
• Used to alleviate symptoms of depression, enhancing mood and emotional well-being.
• Used for certain eating disorders, such as bulimia nervosa, to help manage symptoms.
• Used for managing chronic insomnia, aiding in the restoration of a healthy sleep cycle.
• Used for treating certain phobias, assisting in reducing fear and anxiety associated with specific triggers.

In the case of an overdose of Clomipramine 10mg Tablets, immediate medical attention is necessary. Symptoms of overdose may include severe drowsiness, agitation, confusion, rapid heartbeat, seizures, and even loss of consciousness. It is crucial to contact a healthcare professional or a poison control center for guidance. Prompt action can help manage the effects of an overdose and ensure the best possible outcome for the patient.

In the case of a missed dose of Clomipramine 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they may advise you to restart the medication or adjust the dosage accordingly. It is essential to maintain a consistent routine when taking this medication.

To take Clomipramine 10mg Tablets, swallow the tablet whole with a full glass of water, preferably in the morning or as directed by your healthcare professional, following the prescribed dosage and not exceeding the recommended amount.

Following are the conditions/situations when Clomipramine 10mg Tablet should not be taken:

• Should not be taken by individuals with a known allergy to Clomipramine or tricyclic antidepressants.
• Contraindicated in patients with a history of seizures or epilepsy.
• Not suitable for individuals with severe liver or kidney disease.
• Should be avoided in patients with glaucoma or urinary retention.
• Must not be used in patients with a recent heart attack or those with severe heart disease.
• Contraindicated during pregnancy or breastfeeding.
• Not recommended for children under 18 years of age.
• Should not be combined with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI treatment.
• Avoid if you have a history of blood disorders or bone marrow depression.
• Do not take if you have a history of suicidal behavior or thoughts.

The side effects of Clomipramine 10mg Tablet may include:

• Dry mouth
• Constipation
• Dizziness
• Drowsiness
• Nausea and vomiting
• Blurred vision
• Increased heart rate
• Weight gain

Following are the precautions and warnings for Clomipramine 10mg Tablet:

• This medication should be used with caution in patients with a history of liver or kidney disease, as it may require dosage adjustments.
• Patients with a history of seizures or epilepsy should be closely monitored, as Clomipramine can lower the seizure threshold.
• Clomipramine may cause dizziness and sleepiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• It is important to avoid alcohol consumption while taking this medication, as it can increase the risk of side effects.
• Elderly patients may be more sensitive to the side effects, and regular monitoring is necessary.
• Patients with heart-related conditions should be cautious, as Clomipramine may affect heart rhythm and blood pressure.
• Do not abruptly stop taking Clomipramine; gradually reducing the dosage as directed by a healthcare professional is essential to prevent withdrawal symptoms.
• Inform your doctor about all medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Clomipramine 10mg Tablet:

• Serotonin syndrome risk is increased when combined with other serotonergic agents like SSRIs, SNRIs, triptans, or tramadol.
• Severe reactions, including seizures and hyperthermia, may occur with monoamine oxidase inhibitors (MAOIs). Avoid concurrent use.
• The effects of central nervous system (CNS) depressants, such as benzodiazepines and alcohol, can be enhanced, leading to increased sedation and respiratory depression.
• Clomipramine may increase the concentration of certain anticonvulsants (e.g., phenytoin, carbamazepine), requiring monitoring and dose adjustments.
• Anticoagulants like warfarin may have their effects potentiated, necessitating close monitoring of coagulation parameters.
• Antipsychotics and other medications metabolized by CYP2D6 may have increased plasma levels, leading to potential toxicity.
• Drugs that affect liver enzymes, particularly CYP2D6 inhibitors, can alter Clomipramine metabolism, requiring dosage adjustments.

Following are the food interactions for Clomipramine 10mg Tablet:

• Consuming grapefruit or grapefruit juice should be avoided as it may interfere with the metabolism of Clomipramine, leading to increased drug levels in the body and potential side effects.
• Alcohol consumption should be minimized or avoided as it can enhance the sedative effects of Clomipramine, causing excessive drowsiness and impaired coordination.
• Caffeine intake should be monitored as it can interact with Clomipramine, potentially increasing anxiety and affecting sleep patterns.
• Foods rich in tyramine, such as aged cheeses, cured meats, and certain types of beer, should be limited as they may interact with Clomipramine and raise blood pressure.
• Fatty meals may slightly delay the absorption of Clomipramine, but this effect is usually not clinically significant.
• It is advisable to maintain a balanced diet and stay well-hydrated to support overall health while taking this medication.
• Always consult your healthcare provider for personalized advice regarding dietary considerations and potential food interactions.

Clomipramine 10mg Tablets should be stored in a secure and dry location, protected from moisture and light. Maintain a consistent room temperature, avoiding extreme heat or cold. It is crucial to keep the medication in its original container, tightly sealed, to prevent contamination. Regularly check the expiration date on the packaging, and never use the tablets beyond their expiry. When disposing of unused or expired medication, do not flush or pour it down the drain. Instead, consult your pharmacist or local waste management guidelines for safe disposal options. Always ensure that the medication is kept out of children's reach to prevent accidental consumption.

Following are the quick tips for Clomipramine 10mg Tablet:

• Start with a low dose and gradually increase as directed by your doctor.
• Take the tablet at the same time each day to maintain consistent levels.
• Swallow the tablet whole with a full glass of water, preferably in the morning.
• Do not crush, chew, or break the tablet.
• Avoid alcohol consumption while taking this medication.
• Inform your doctor about all medications you are currently taking.
• Regularly monitor your progress and any side effects with your healthcare provider.
• Store the medication in a cool, dry place, away from direct sunlight.