Clomipril (75mg) 20 Tablets

Clomipramine 75mg Tablet primarily exerts its therapeutic effects through its potent inhibition of serotonin reuptake in the brain. By blocking the serotonin transporter, clomipramine increases the availability of serotonin in the synaptic cleft, enhancing serotonergic neurotransmission. This mechanism is crucial in treating various conditions, as serotonin modulation plays a significant role in regulating mood, emotions, and anxiety. Clomipramine's selective serotonin reuptake inhibition is believed to contribute to its antidepressant and anxiolytic properties, making it effective in managing depression and obsessive-compulsive disorder.

Clomipramine 75mg

Tricyclic antidepressant.

Tablet

The following are the uses of Clomipramine 75mg Tablet:

• Used for treating obsessive-compulsive disorder (OCD), helping to reduce persistent, repetitive thoughts and behaviors.
• Used for managing severe depression, especially when other antidepressants have been ineffective.
• Used to alleviate symptoms of panic disorder, including panic attacks and intense anxiety.
• Effective in treating certain types of phobias, helping individuals confront and manage their fears.
• Can be utilized for managing chronic pain, particularly in conditions like fibromyalgia.
• Assists in reducing instances of bedwetting (nocturnal enuresis) in children.
• Used in the management of premature ejaculation, helping to improve sexual control.

In the case of an overdose of Clomipramine 75mg Tablets, immediate medical attention is necessary. Symptoms may include severe drowsiness, agitation, confusion, seizures, and an irregular heartbeat. Promptly contact a healthcare professional or go to the nearest emergency room for treatment. Treatment may involve managing symptoms, monitoring vital signs, and providing supportive care. It is important to seek professional help to ensure appropriate management of the overdose.

In the case of a missed dose of Clomipramine 75mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is generally recommended to take the medication at the same time each day to maintain consistent levels in your body.

To take Clomipramine 75mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically starting with a lower dose and gradually increasing as directed.

Following are the conditions when Clomipramine 75mg Tablet should not be taken:

• Do not take if you have a known allergy to Clomipramine or any tricyclic antidepressants.
• Avoid if you have recently suffered a heart attack.
• Should not be used in individuals with a history of seizures or epilepsy.
• Contraindicated in patients with narrow-angle glaucoma.
• Not suitable for those with severe liver or kidney impairment.
• Do not consume alcohol while taking this medication.
• Avoid if you have a history of urinary retention or difficulty urinating.
• Should not be taken by individuals with a blood disorder or a history of low blood cell counts.
• Stop taking if you experience any severe side effects such as severe dizziness, fainting, or abnormal heart rhythm.

The side effects of Clomipramine 75mg Tablet may include:

• Dry mouth
• Constipation
• Dizziness or lightheadedness
• Blurred vision
• Increased heart rate or palpitations
• Weight gain
• Tremors
• Difficulty urinating

Here are the precautions and warnings for Clomipramine 75mg Tablet:

• Do not start or continue Clomipramine if you have a known allergy to clomipramine or any other tricyclic antidepressants.
• This medication may cause drowsiness and affect your ability to drive or operate machinery; avoid such activities until you know how the medication affects you.
• Clomipramine may interact with other medications; inform your doctor about all the medicines, supplements, or herbal products you are taking.
• It should be used with caution in patients with a history of seizures, as it may lower the seizure threshold.
• Patients with cardiovascular problems should be closely monitored, as Clomipramine can affect heart rate and blood pressure.
• Elderly patients may be more sensitive to the side effects; dosage adjustments might be necessary.
• Consult your doctor if you have a history of liver or kidney disease, as these conditions may require close monitoring.
• If you experience any severe side effects or symptoms of an allergic reaction, seek immediate medical attention.

Following are the drug interactions for Clomipramine 75mg Tablet:

• Clomipramine may interact with other antidepressants like selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs), increasing the risk of serotonin syndrome, a potentially serious condition.
• It can enhance the effects of central nervous system depressants, including alcohol, benzodiazepines, and opioids, leading to increased sedation and respiratory depression.
• Use with tricyclic antidepressants (TCAs) may cause additive effects and increased side effects.
• Antipsychotic medications may have their effects and side effects enhanced when used with Clomipramine.
• The effectiveness of anticonvulsant drugs may be reduced by Clomipramine, requiring careful monitoring.
• Blood pressure medications, particularly beta-blockers, may have their effects reduced by Clomipramine.
• Clomipramine may also interact with medications metabolized by the liver, potentially altering their effectiveness and side effect profile.

Following are the food interactions for Clomipramine 75mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase the drug's bioavailability, leading to increased side effects.
• Alcohol is not recommended as it can enhance the sedative effects of Clomipramine, causing increased drowsiness and dizziness.
• Consuming foods high in tyramine, such as aged cheeses, cured meats, and fermented foods, should be avoided as they may interact with Clomipramine, leading to a potentially dangerous spike in blood pressure.
• Avoid caffeine-rich foods and beverages as they can exacerbate the drug's side effects, particularly nervousness and insomnia.
• There is no specific food requirement for the medication's absorption, but maintaining a balanced diet is advisable.
• Always follow the dosage instructions provided by your healthcare professional to ensure optimal effectiveness and minimize the risk of adverse effects.
• If you have any specific dietary concerns or questions, consult your healthcare provider for personalized advice.

Clomipramine 75mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or designated storage area. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to moisture or humidity. It is crucial to store them at room temperature, avoiding extreme heat or cold, as temperature fluctuations can impact the medication's effectiveness. Do not store the tablets in the bathroom or kitchen, as these areas may have higher humidity levels. Always check the expiration date, and dispose of any expired or unused tablets promptly. Proper disposal methods should be followed, such as returning them to a pharmacy or healthcare facility, to prevent environmental contamination and ensure the safe disposal of pharmaceutical waste. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Clomipramine 75mg Tablet:

• Start with a lower dose and gradually increase as directed by your doctor.
• Swallow the tablet whole, do not crush or chew.
• Take the tablet at the same time each day for consistent benefits.
• Avoid alcohol consumption while on this medication.
• Inform your doctor about all medications you are taking to prevent interactions.
• Do not stop taking the medication suddenly, follow your doctor's instructions.
• Store the medication in a cool, dry place, away from direct sunlight.
• Contact your doctor if you experience any severe or persistent side effects.