Clopid-ASP (75/150mg) 10 Tablets

Aspirin 75mg and Clopidogrel 75mg Tablet both play crucial roles in inhibiting platelet aggregation, thereby reducing the risk of blood clots. Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1) in platelets, preventing the production of thromboxane A2, a potent inducer of platelet aggregation and vasoconstriction. This inhibition makes platelets less sticky and less likely to form clots. On the other hand, Clopidogrel is a prodrug that requires activation by liver enzymes to form its active metabolite. This active metabolite irreversibly inhibits the P2Y12 receptor on platelets, leading to reduced activation and aggregation of platelets. By blocking different pathways involved in platelet activation and aggregation, the combination of Aspirin and Clopidogrel provides a synergistic effect in preventing blood clots, making it effective in various cardiovascular conditions.

Aspirin 75mg, Clopidogrel 75mg

Antiplatelet agents.

Tablet

The following are the uses of Aspirin 75mg, Clopidogrel 75mg Tablet:

• Used for preventing blood clots in patients at risk of heart attack or stroke.
• Used to manage unstable angina and acute coronary syndrome.
• Used for reducing the risk of blood clots after certain surgeries or medical procedures.
• Used to prevent clot formation in patients with atrial fibrillation.
• Used as a long-term treatment for peripheral artery disease.
• Used in combination with other medications to manage heart and blood vessel conditions.
• Used to prevent clot-related complications in patients with certain medical conditions.

In the case of an overdose of Aspirin 75mg and Clopidogrel 75mg tablets, individuals may experience symptoms such as rapid breathing, ringing in the ears, and gastrointestinal issues like nausea and vomiting. Prompt medical advice is necessary, and healthcare professionals should be contacted immediately. They can provide guidance on the appropriate steps to take, which may include inducing vomiting or administering activated charcoal to prevent further absorption of the medication. It is crucial to act swiftly to minimize potential harm.

In the case of a missed dose of Aspirin 75mg, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. If it is near the time of your next dose, skip the missed dose and continue with your regular dosing schedule. For Clopidogrel 75mg Tablet, if you miss a dose, take it as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and continue with your regular dosing regimen. It is important to maintain a consistent medication routine for both these medications.

To take the Aspirin 75mg and Clopidogrel 75mg Tablet, swallow the tablet whole with a full glass of water, preferably with food, once daily, as directed by your healthcare professional.

Following are the conditions or situations when Aspirin 75mg, Clopidogrel 75mg Tablet should not be used:

• Do not take this medication if you have an active stomach ulcer or bleeding disorder.
• Avoid if you are allergic to non-steroidal anti-inflammatory drugs (NSAIDs) or any other ingredients in the medication.
• Should not be used in individuals with a history of allergic reactions to Clopidogrel or related medications.
• Contraindicated for patients with severe liver or kidney impairment.
• Do not use if you have recently had a stroke, especially a hemorrhagic stroke.
• Avoid if you have a bleeding disorder or a history of bleeding in the brain.
• Not suitable for individuals with severe hypertension (high blood pressure) that is uncontrolled.

The side effects of Aspirin 75mg and Clopidogrel 75mg Tablet may include:

• Easy bruising or bleeding (nosebleeds, bleeding gums, or prolonged bleeding from cuts)
• Stomach pain, heartburn, or indigestion
• Nausea and vomiting
• Headache or dizziness
• Skin rash or itching
• Constipation or diarrhea
• Fatigue or weakness

Following are the precautions and warnings for Aspirin 75mg, Clopidogrel 75mg Tablet:

• This medication should not be taken by individuals with a known allergy to aspirin, clopidogrel, or other related drugs.
• Patients with bleeding disorders or a history of stomach ulcers should use this medication with caution, as it may increase the risk of bleeding.
• Alcohol consumption should be avoided or limited while taking this medication, as it can increase the risk of stomach bleeding.
• Patients should inform their doctor about all medications they are currently taking to avoid potential drug interactions.
• It is important to avoid activities that may increase the risk of bleeding or injury while on this medication, such as contact sports.
• Patients should not stop taking this medication without consulting their doctor, as sudden discontinuation may increase the risk of blood clots.
• Individuals with liver or kidney disease should be monitored closely while on this treatment.
• Consult a healthcare professional if you are pregnant, planning to become pregnant, or breastfeeding, as this medication may not be suitable for you.

Following are the drug interactions for Aspirin 75mg, Clopidogrel 75mg Tablet:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce the anti-platelet effect of Clopidogrel.
• Proton pump inhibitors (PPIs) such as omeprazole may decrease the effectiveness of Clopidogrel.
• Aspirin may increase the risk of bleeding when taken with anticoagulants, including warfarin.
• Thrombolytic agents (e.g., streptokinase) can increase the risk of bleeding when combined with Aspirin and Clopidogrel.
• Clopidogrel's effectiveness may be reduced by calcium channel blockers like verapamil.
• Antiepileptic drugs (e.g., phenytoin) can decrease Clopidogrel's active metabolite formation.
• Drugs that induce CYP450 enzymes, such as rifampicin, may reduce Clopidogrel's efficacy.
• Certain herbal supplements (e.g., St. John's Wort) can impact Clopidogrel metabolism and reduce its effectiveness.

Following are the food interactions for Aspirin 75mg and Clopidogrel 75mg Tablet:

• Avoid excessive alcohol consumption while taking these medications, as alcohol can increase the risk of stomach bleeding and interfere with the platelet-inhibiting effects.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Clopidogrel, potentially reducing its effectiveness.
• Avoid high-fat meals, as they can decrease the absorption and effectiveness of Clopidogrel.
• Avoid foods rich in Vitamin K (like spinach, kale, and broccoli) as they can reduce the anticoagulant effect of Aspirin.
• Limit caffeine intake, as it may increase the risk of bleeding when combined with these medications.
• Avoid herbal supplements like Ginkgo Biloba and St. John's Wort, as they can impact platelet function and interact with these medications.
• Be cautious with salty foods, as Aspirin can increase sodium retention, affecting blood pressure.
• Consult a healthcare provider for specific dietary guidelines, especially if you have a history of gastrointestinal issues or are on a restricted diet.

Aspirin 75mg and Clopidogrel 75mg tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent exposure to air. It is crucial not to store them in the bathroom or near heat sources, as temperature fluctuations can impact their effectiveness. Regularly check the expiration date, and dispose of any expired or unused tablets promptly. For proper disposal, avoid flushing or pouring them down the drain; consult a pharmacist or healthcare professional for safe disposal practices. Keep all medications out of children's reach to prevent accidental ingestion.

Following are the quick tips for Aspirin 75mg, Clopidogrel 75mg Tablet:

• Consult a doctor for the right dosage and duration of medication.
• Take the tablet with or after food to prevent stomach irritation.
• Do not crush or chew the tablet; swallow it whole with water.
• Maintain a consistent medication schedule for maximum effectiveness.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Avoid alcohol consumption as it may increase the risk of bleeding.
• Regularly monitor your blood pressure and report any unusual bleeding or bruising.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.