CLOPRA 25MG TAB 20S

Clomipramine 25mg Tablet primarily exerts its therapeutic effects through the potent inhibition of serotonin (5-HT) reuptake in the brain. This mechanism of action is attributed to its structural similarity to tricyclic antidepressants (TCAs), allowing it to bind to the presynaptic serotonin transporter and block the reabsorption of serotonin into the presynaptic neuron. By inhibiting serotonin reuptake, clomipramine increases the availability of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission. This heightened serotonin activity is believed to play a crucial role in alleviating symptoms associated with various conditions, particularly in the treatment of obsessive-compulsive disorder (OCD) and certain types of depression.

Clomipramine 25mg

Tricyclic antidepressant.

Tablet

The following are the uses of Clomipramine 25mg Tablet:

• Used for treating obsessive-compulsive disorder (OCD), helping to reduce persistent, repetitive thoughts and compulsive behaviors.
• Used for alleviating symptoms of panic disorder, including panic attacks and severe anxiety.
• Used for managing severe phobias, such as social phobia, by reducing anxiety and fear responses.
• Used for treating major depressive disorder, particularly when other antidepressants have been ineffective.
• Used for managing chronic pain conditions like neuralgia and fibromyalgia by affecting pain perception.
• Used for reducing certain types of chronic headaches and migraines by influencing neurotransmitters.
• Used for supporting the treatment of certain eating disorders, such as anorexia nervosa, by addressing anxiety and obsessive thoughts.

To be taken as per doctor's prescription

In the case of an overdose of Clomipramine 25mg Tablets, individuals may experience severe symptoms such as seizures, rapid heartbeat, dizziness, and even loss of consciousness. Prompt action is required, including contacting emergency medical services for immediate assistance. It is crucial to remain calm and provide the necessary information to medical professionals, including the dosage taken and the time of ingestion, to ensure appropriate treatment and support during this critical situation.

In the case of a missed dose of Clomipramine 25mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication without affecting its efficacy.

To take Clomipramine 25mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Clomipramine 25mg Tablet should not be taken:

• Avoid use in individuals with a known hypersensitivity or allergy to Clomipramine or tricyclic antidepressants.
• Not suitable for individuals with a history of seizures or epilepsy.
• Contraindicated in patients with recent myocardial infarction (heart attack).
• Should not be used in patients with severe liver or kidney impairment.
• Avoid use in individuals with narrow-angle glaucoma.
• Not recommended for those with severe urinary retention.
• Contraindicated in patients currently taking or recently treated with Monoamine Oxidase Inhibitors (MAOIs).
• Should not be used in individuals with severe cardiovascular disease or arrhythmias.
• Avoid use during the recovery period after surgery.
• Not suitable for patients with a history of manic-depressive illness.

The side effects of Clomipramine 25mg Tablet may include:

• Dry mouth
• Constipation
• Dizziness
• Drowsiness
• Blurred vision
• Increased appetite and weight gain
• Tremors
• Confusion, especially in elderly patients

Following are the precautions and warnings for Clomipramine 25mg Tablet:

• Do not start or stop taking this medication without consulting your doctor, as sudden discontinuation may lead to withdrawal symptoms.
• Patients with a history of seizures or epilepsy should use Clomipramine with caution, as it may lower the seizure threshold.
• Blood pressure and heart rate should be monitored regularly during treatment, especially in patients with cardiovascular conditions.
• Elderly patients may be more sensitive to the side effects, particularly anticholinergic effects and sedation.
• Clomipramine may cause dry mouth; good oral hygiene is important to reduce the risk of dental problems.
• It may impair your ability to drive or operate machinery, especially during the initial period of treatment.
• This medication should be used with caution in patients with liver or kidney disease, as it may require dosage adjustments.

Following are the drug interactions for Clomipramine 25mg Tablet:

• Concomitant use with other antidepressants like SSRIs or MAOIs can lead to serotonin syndrome, a serious and potentially fatal condition.
• Clomipramine may enhance the effects of central nervous system depressants, including alcohol, opioids, and benzodiazepines, resulting in increased sedation.
• Drugs metabolized by CYP2D6 enzyme may have their metabolism inhibited, leading to increased blood levels of these medications.
• It can interact with antihypertensive medications, causing a potential increase in blood pressure.
• The effectiveness of thyroid medications may be reduced due to Clomipramine's potential interference with thyroid hormone absorption.
• Anticonvulsant levels may be altered, requiring monitoring and dosage adjustments.
• Blood thinners might have their effect potentiated, necessitating close monitoring for bleeding.

Following are the food interactions for Clomipramine 25mg Tablet:

• Avoid consuming alcohol as it can increase the sedative effects and may lead to excessive drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Clomipramine, potentially increasing its levels in the blood and the risk of side effects.
• Foods rich in tyramine (aged cheeses, cured meats, fermented foods) should be avoided as Clomipramine may interact with tyramine, leading to a sudden increase in blood pressure.
• Avoid caffeine or reduce its intake as it can exacerbate anxiety and interfere with sleep, counteracting the therapeutic effects of Clomipramine.
• High-fat meals may delay the absorption of Clomipramine, potentially affecting its onset of action.
• Avoid herbal supplements like St. John's Wort, as it can decrease Clomipramine's effectiveness and increase the risk of side effects.
• Always ensure a balanced diet, as Clomipramine may increase appetite and lead to weight gain.
• Consult your healthcare provider for personalized dietary advice, especially if you have specific health conditions or concerns.

Clomipramine 25mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from moisture and direct sunlight. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. Always check the expiration date before use and never use the medication beyond its expiry. When disposing of unused or expired tablets, do not flush them down the toilet or discard them into the trash. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for safe and environmentally friendly disposal options. Ensure that the medication is kept out of the reach of children and pets to prevent accidental ingestion, as it can be harmful if consumed without medical supervision.

No

Following are the quick tips for Clomipramine 25mg Tablet:

• Start with a lower dose and gradually increase as directed by your doctor.
• Take the tablet at the same time each day for consistent results.
• Swallow the tablet whole with a full glass of water.
• Do not crush, chew, or break the tablet.
• Avoid alcohol consumption while taking this medication.
• Inform your doctor about all medications you are currently taking.
• Regularly monitor your progress and report any changes to your doctor.
• Store the medication in a cool, dry place, away from direct sunlight.