CLOSERIN 250MG CAP

Cycloserine primarily acts as a bactericidal antibiotic, specifically targeting the cell wall synthesis of susceptible bacteria. Its mechanism of action involves inhibiting the activity of two enzymes, D-alanine racemase and D-alanine-D-alanine ligase, which are crucial for the formation of peptidoglycan, a major component of the bacterial cell wall. By disrupting the synthesis of peptidoglycan, cycloserine weakens the structural integrity of the bacterial cell wall, leading to cell lysis and death. This antibiotic is particularly effective against mycobacterial species, including Mycobacterium tuberculosis, as it can penetrate and accumulate within these bacteria, exerting its bactericidal effect.

Cycloserine 250mg

Antibiotic

Capsule

The following are the uses of Cycloserine 250mg Capsule:

• Used for treating Tuberculosis (TB), especially in cases where the bacteria have become resistant to other medications.
• Used for controlling and preventing the growth of TB bacteria in the body.
• Used for managing active pulmonary and extrapulmonary TB.
• Used for improving lung function and reducing symptoms in TB patients.
• Used as an alternative treatment option when other TB drugs cannot be tolerated or are ineffective.
• Used in combination with other antituberculosis drugs for comprehensive TB treatment.
• Used under strict medical supervision due to potential side effects and the need for regular monitoring.

In the case of an overdose of Cycloserine 250mg capsules, individuals may experience symptoms such as seizures, confusion, and changes in mental status. It is important to seek medical assistance promptly if an overdose is suspected. Treatment may involve monitoring vital signs, providing supportive care, and managing any seizures or neurological complications that arise. Quick action can help mitigate the potential harm caused by ingesting an excessive amount of this medication.

In the case of a missed dose of Cycloserine 250mg Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication and maintain the effectiveness of the treatment. It is crucial to adhere to the prescribed dosing regimen to ensure the medication's optimal benefits.

To take Cycloserine 250mg Capsule, swallow the capsule whole with a full glass of water, ensuring you do not break or chew the capsule, as directed by your healthcare professional, typically twice a day, with or without food, at evenly spaced intervals.

Here are the conditions or situations when Cycloserine 250mg Capsule should not be used:

• Avoid using if you have a known allergy to Cycloserine or any other similar medications.
• Not recommended for individuals with a history of central nervous system (CNS) disorders or seizures.
• Contraindicated in patients with severe kidney or liver disease.
• Should not be used in individuals with a history of psychiatric disorders, including depression, anxiety, or psychosis.
• Not suitable for those with a history of alcohol abuse or dependency.
• Do not use if you have a condition called pyridoxine deficiency, or if you are taking medications that reduce the levels of vitamin B6 in the body.
• Avoid using Cycloserine if you have had a recent brain or head injury.
• Contraindicated during pregnancy and breastfeeding.

The side effects of Cycloserine 250mg Capsule may include:

• Nausea and vomiting
• Loss of appetite
• Diarrhea
• Skin rashes or itching
• Confusion or disorientation
• Seizures
• Anxiety or depression
• Increased urination

Following are the precautions and warnings for Cycloserine 250mg Capsule:

• Do not take this medication if you have a history of hypersensitivity or severe allergic reactions to Cycloserine or similar medications.
• Cycloserine may cause changes in mental health, including depression, anxiety, or psychotic symptoms. Monitor for any behavioral changes and seek medical attention if necessary.
• Regular monitoring of kidney function is essential during treatment, as Cycloserine can affect kidney health.
• Avoid alcohol consumption while taking Cycloserine, as it may increase the risk of side effects.
• This medication may cause dizziness or drowsiness. Do not drive or operate heavy machinery until you know how Cycloserine affects you.
• Cycloserine should be used with caution in elderly patients, as they may be more susceptible to its side effects.
• Inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Cycloserine 250mg Capsule:

• Alcohol consumption should be avoided as it can increase the risk of seizures and other side effects.
• Combining with phenytoin, phenobarbital, or other anticonvulsants may reduce Cycloserine's effectiveness, requiring close monitoring.
• When taken with trimethoprim, the levels of Cycloserine can increase, potentially leading to toxicity.
• Rifampin may decrease Cycloserine levels, thus reducing its effectiveness.
• Ethionamide can increase Cycloserine's toxicity risk.
• Pyridoxine (vitamin B6) may reduce Cycloserine's effectiveness.
• Concurrent use with other medications that lower the seizure threshold, such as certain antidepressants or antipsychotics, may increase the risk of seizures.

Following are the food interactions for Cycloserine 250mg Capsule:

• Alcohol should be avoided or limited as it may increase the risk of side effects, particularly nervous system-related issues.
• Ensure adequate folic acid intake as Cycloserine can interfere with folate metabolism. Include foods rich in folate like leafy greens, legumes, and citrus fruits.
• Maintain a balanced diet with sufficient protein, vitamins, and minerals. Cycloserine may affect vitamin B6 levels, so include foods like poultry, fish, and whole grains.
• Avoid excessive consumption of tyramine-rich foods like aged cheeses, cured meats, and certain types of beer, as Cycloserine may interact with tyramine.
• Limit or avoid caffeine as it can increase nervous system stimulation and potentially worsen side effects.
• Stay hydrated and drink plenty of fluids to support overall health while taking Cycloserine.
• There are no specific food restrictions, but maintaining a healthy diet is essential for overall well-being during Cycloserine therapy.

Cycloserine 250mg capsules should be stored in a cool, dry area, preferably at room temperature, away from sunlight and moisture. It is crucial to keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the capsules to heat or cold, as temperature fluctuations can impact their effectiveness. When discarding any unused or expired capsules, do not flush them or pour them down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal practices. Always keep medicines out of children's reach to prevent accidental consumption, and ensure proper handling and storage to maintain the medication's quality and safety.

Following are the quick tips for Cycloserine 250mg Capsule:

• Take the capsule as directed by your doctor, typically 2-4 times daily, to ensure effectiveness.
• Consume the capsule with a full glass of water, preferably on an empty stomach, for better absorption.
• Maintain a consistent dosing schedule; take it at evenly spaced intervals.
• Do not crush or chew the capsule; swallow it whole for optimal results.
• Inform your doctor if you have any kidney or liver issues before taking this medication.
• Avoid alcohol as it may increase the risk of side effects.
• Regular blood tests may be required to monitor your response to the medication.