Co-Amotac (10/25mg) 20 Tablets

Hydrochlorothiazide and Enalapril are combined in this tablet to treat hypertension. Hydrochlorothiazide is a diuretic that works by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidneys, leading to increased excretion of water and electrolytes, which helps lower blood pressure. Enalapril, on the other hand, is an angiotensin-converting enzyme (ACE) inhibitor. It blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. By inhibiting ACE, Enalapril reduces the formation of angiotensin II, leading to vasodilation and decreased blood pressure. This dual mechanism of action effectively lowers blood pressure by promoting fluid loss and relaxing blood vessels.

Hydrochlorothiazide 25mg, Enalapril 25mg

Angiotensin-converting enzyme (ACE) inhibitor, diuretic.

Tablet

The following are the uses of Hydrochlorothiazide 25mg, Enalapril 25mg Tablet:

• Used for treating high blood pressure (hypertension) to lower the risk of associated health issues like strokes, heart attacks, and kidney problems.
• Used for managing fluid retention (edema) caused by various conditions, helping to reduce swelling and improve related discomfort.
• Used for improving heart function in patients with left ventricular dysfunction, enhancing the heart's pumping ability.
• Used for reducing the risk of heart-related events, such as heart failure, in individuals with specific cardiac conditions.
• Used for controlling symptoms of kidney disease by managing blood pressure and fluid balance.
• Used for supporting overall cardiovascular health and preventing potential complications in at-risk individuals.
• Used for long-term management of hypertension and related cardiovascular risks, often in combination with lifestyle changes.

In the case of an overdose of Hydrochlorothiazide 25mg and Enalapril 25mg tablets, symptoms may include excessive urination, dizziness, low blood pressure, and an irregular heartbeat. Prompt medical attention is essential as this combination can lead to severe dehydration, electrolyte imbalances, and potentially life-threatening complications. Treatment may involve supportive care, monitoring vital signs, and managing symptoms until the effects of the overdose subside. It is crucial to seek medical help immediately if an overdose is suspected.

In the case of a missed dose of Hydrochlorothiazide 25mg, it is recommended to take the missed dose as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. For Enalapril 25mg, if you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and do not double the dose to catch up. It's important to maintain a consistent medication schedule, but if you frequently miss doses, consult your healthcare provider for advice on how to improve adherence.

To take Hydrochlorothiazide 25mg and Enalapril 25mg tablets, swallow one tablet with a glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare provider.

Following are the conditions or situations when Hydrochlorothiazide 25mg and Enalapril 25mg Tablet should not be used:

• Should not be used in patients with a known allergy to either Hydrochlorothiazide or Enalapril or any other ACE inhibitors.
• Contraindicated in individuals with a history of angioedema or hereditary angioedema.
• Not suitable for patients with severe renal impairment or those who are anuric (unable to produce urine).
• Should not be used during pregnancy, especially in the second and third trimesters.
• Contraindicated in patients with severe hepatic impairment or liver disease.
• Not recommended for individuals with hyperkalemia (high potassium levels in the blood).
• Should be avoided in patients with bilateral renal artery stenosis or unilateral stenosis in a solitary kidney.
• Should not be used in patients with a history of hypersensitivity reactions to other sulfonamide-derived drugs.

The side effects of Hydrochlorothiazide 25mg, Enalapril 25mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Dry mouth or excessive thirst
• Nausea and vomiting
• Skin rash or itching
• Muscle cramps or joint pain
• Electrolyte imbalances (such as low potassium or sodium levels)
• Increased sensitivity to sunlight

Following are the precautions and warnings for Hydrochlorothiazide 25mg, Enalapril 25mg Tablet:

• Patients with a known allergy to hydrochlorothiazide, enalapril, or related ACE inhibitors should not take this medication.
• Regular monitoring of kidney function and blood electrolytes is crucial, especially in patients with pre-existing kidney disease.
• Diabetic patients should closely monitor blood sugar levels as the medication may alter glucose metabolism.
• Caution is advised for patients with a history of liver problems, as it may impact liver function.
• Inform your doctor if you have any cardiovascular conditions, as the medication can affect blood pressure and heart function.
• Do not use potassium supplements or potassium-rich alternatives without medical advice while on this medication.
• Pregnant and breastfeeding women should consult their healthcare provider before taking this medication, as it may cause harm to the fetus or infant.

Following are the drug interactions for Hydrochlorothiazide 25mg and Enalapril 25mg Tablet:

• Lithium and non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of kidney problems when used with Hydrochlorothiazide.
• Enalapril may enhance the effects of other blood pressure-lowering medications, leading to hypotension.
• The effectiveness of diuretics, including Hydrochlorothiazide, can be reduced by corticosteroids and estrogens.
• Hydrochlorothiazide may decrease the elimination of lithium, potentially increasing lithium toxicity.
• Concomitant use of Enalapril with potassium-sparing diuretics or potassium supplements may lead to hyperkalemia.
• The risk of angioedema is increased when Enalapril is combined with neprilysin inhibitors or sacubitril.
• Hydrochlorothiazide may lower blood sugar levels, so adjustments in antidiabetic medications may be necessary.
• NSAIDs can decrease the antihypertensive effect of Enalapril, and the combination may increase the risk of renal impairment.

Following are the food interactions for Hydrochlorothiazide 25mg and Enalapril 25mg Tablet:

• Avoid excessive salt intake, as Hydrochlorothiazide is a diuretic and can lead to increased sodium loss, potentially causing electrolyte imbalances.
• Potassium-rich foods like bananas, oranges, and spinach are beneficial as Enalapril may cause potassium loss.
• Limit alcohol consumption as it can increase the risk of dizziness and hypotension, especially with Enalapril.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the metabolism of Enalapril, leading to increased drug levels and potential side effects.
• Maintain a consistent fluid intake to prevent dehydration, as Hydrochlorothiazide can increase urine output.
• Avoid or limit high-potassium foods like tomatoes, avocados, and certain dairy products if you have kidney problems, as Enalapril can affect potassium levels.
• Consult a dietician or healthcare provider for personalized dietary advice, especially if you have specific dietary restrictions or medical conditions.

Hydrochlorothiazide 25mg, Enalapril 25mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to external elements. It is crucial to adhere to the storage instructions to ensure the medication's effectiveness. When disposing of unused or expired tablets, avoid flushing them down the toilet or sink. Instead, consult your local pharmacist or healthcare professional for appropriate disposal methods to minimize environmental impact. Keep all medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Hydrochlorothiazide 25mg and Enalapril 25mg Tablet:

• Take the medication as directed by your doctor, usually once daily.
• It is best to take the tablet at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Avoid taking antacids or potassium supplements within 4 hours of this medication.
• Inform your doctor if you have a history of kidney or liver problems.
• Regular blood tests may be required to monitor kidney function and electrolyte levels.
• Store the tablets in a cool, dry place, away from direct sunlight.