CO Aprovel (150/12.5mg) 28 Tablets

Irbesartan is a selective competitive angiotensin II receptor type 1 (AT1) antagonist. Angiotensin II is a vasoconstrictor that promotes renal sodium retention and potassium excretion, increases blood pressure, causes peripheral arterial vasoconstriction, cardiac ventricular hypertrophy, and myocardial contractility. By blocking the AT1 receptor, Irbesartan prevents increased blood pressure and cardiac contraction. Irbesartan's efficacy is based on both peripheral and renal (nephron-protective) actions. Hydrochlorothiazide is a thiazide diuretic that inhibits the sodium-chloride symporter in the distal renal tubule. By inhibiting reabsorbtion of sodium and chloride ions, hydrochlorothiazide promotes natriuresis and distal renal tubular water conservation, resulting in increased urine volume and decreased blood pressure. It also inhibits calcium reabsorbtion leading to increased excretion and decreased plasma levels. The decreased blood pressure further reduces sympathetic neural stimulation of the renin-angiotensin-aldosterone system (RAAS), which exacerbates hypertension. Hydrochlorothiazide has a relatively low potassium-sparing effect, increasing the risk of potassium deficiency. Together, Irbesartan and Hydrochlorothiazide work in conjunction to help treat hypertension.

Hydrochlorothiazide, Irbesartan

Irbesartan:

Tablet

Hydrochlorothiazide, Irbesartan combination is utilized for the following therapeutic indications:

• Managing hypertension (high blood pressure)
• Providing complementary effects in blood pressure control
• Reducing the risk of stroke and myocardial infarction
• Renal protection in patients with diabetes
• Enhancing overall cardiovascular health

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Hypertension- Take 1 tablet of Irbesartan 150mg and Hydrochlorothiazide 12.5mg once daily.
• Heart failure- Take 1 tablet of Irbesartan 150mg once daily. If severe, take Irbesartan 300mg once daily.
• Kidney disease- Take Irbesartan 150mg or 300mg once daily.

An Irbesartan-Hydrochlorothiazide overdose can be treated safely and effectively by a medical professional in a hospital setting. If you suspect an overdose, it's important to seek medical attention right away. Your doctor may employ a variety of methods to treat you, including stomach pumping, the use of Activated Charcoal to bind any drugs in the gastrointestinal tract, and laxatives to empty the gut. Depending on your condition, you may require vital signs monitoring, oxygen supplementation, or dialysis. The treatment plan your medical team employs for you will be tailored to the severity of your symptoms and your overall health. It is imperative you contact emergency services immediately if you have overdosed so you can achieve the best possible outcome.

If you miss a dose of Irbesartan 150mg and Hydrochlorothiazide 12.5mg, it is important to determine the best course of action. You may take the missed dose as soon as possible if it is relatively recent. However, if it is almost time for your next scheduled dose, it is recommended to skip the missed dose altogether to avoid doubling up. It is advised to consult with a medical professional who can guide you specifically based on your medication and individual circumstances. They can provide valuable insights and ensure safe and effective usage of the medication.

Before starting to take Irbesartan 150mg and Hydrochlorothiazide 12.5mg, you should read the medication guide provided by your pharmacist. If you have any questions, be sure to ask your doctor or pharmacist. Take this medication by mouth with or without food. Take precautions to not cut or crush the tablet as it can harm the coating. The dosage depends on your medical condition and response to treatment. To reduce side effects, your doctor may gradually increase your dose. Take the medication regularly to get the maximum benefit from it. Take it at the same time each day to help remember to take it. It is important to use this medication for the full course of treatment. Stopping it prematurely or skipping doses can increase the risk of heart attack or stroke. Irbesartan is used to treat high blood pressure, alone or with other medications in adults and children who are at least 6 years old. Hydrochlorothiazide helps to lower blood pressure by removing extra fluid in the body and is considered a diuretic (water pill). If you have any questions or concerns about taking this medication, be sure to ask your healthcare provider.

Discerning instances where this medication may not be appropriate:

• Allergy to irbesartan, hydrochlorothiazide, or any other angiotensin-II receptor blockers (ARBs) or diuretics in the past
• Underlying kidney disease or kidney impairment
• Previous history of liver dysfunction or liver disease
• Pregnancy or planning to conceive
• Congestive heart failure (CHF)
• Sodium levels or potassium levels that are too low or high
• Unexplained weight loss
• Nightmares or hallucinations
• Very low blood pressure or dizziness
• Type 1 or type 2 diabetes mellitus
• It is important to provide your medical history and any current medications you are taking to your doctor to avoid any adverse effects or harmful interactions.

Unraveling the side effects lurking behind this medications are as follows:

• Low blood pressure (hypotension)
• Lightheadedness or dizziness
• Fluid retention and swelling (edema)
• Increased potassium levels in the blood (hyperkalemia)
• Nausea
• Muscle weakness
• Cough
• Decreased appetite
• Vomiting
• Nervousness
• Headache
• Agitation
• Confusion
• Dizziness

Storing Irbesartan 150mg and Hydrochlorothiazide 12.5mg requires specific considerations to maintain the efficacy and safety of the medications. Here are some key instructions: