CO Aprovel (300/12.5mg) 28 Tablets

Irbesartan and hydrochlorothiazide are effective medications for treating high blood pressure, a common medical condition. Irbesartan works by blocking hormones that constrict blood vessels, so it acts as an angiotensin-II receptor antagonist, allowing blood to flow more freely. Hydrochlorothiazide, on the other hand, is a type of diuretic that prevents the body from retaining too much salt and thus retains water, increasing urine production and reducing blood pressure. When combined, these mechanisms help to effectively reduce blood pressure and alleviate the harmful effects of hypertension.

Hydrochlorothiazide, Irbesartan

Irbesartan:

Tablet

Hydrochlorothiazide, Irbesartan combination is utilized for the following therapeutic indications:

• Managing hypertension (high blood pressure)
• Providing complementary effects in blood pressure control
• Reducing the risk of stroke and myocardial infarction
• Renal protection in patients with diabetes
• Enhancing overall cardiovascular health

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Hypertension- Take 1 tablet of Irbesartan 300mg and Hydrochlorothiazide 12.5mg once daily.
• Heart failure- Take 1 tablet of Irbesartan 300mg once daily. Your doctor may prescribe a higher dose of 300mg twice daily if you have severe heart failure.
• Kidney disease- The usual dose ranges from 150mg to 300mg once daily.
• Diabetic nephropathy- Take 300mg once daily.

An Irbesartan-Hydrochlorothiazide overdose can be a concerning situation, but it is important to remain calm and act quickly to ensure the best possible outcome. If you suspect an overdose, the first step is to seek immediate medical attention by calling emergency services or visiting the nearest emergency room. Timely intervention is crucial in managing the situation. Once under the care of medical professionals, a range of treatments may be employed to manage the overdose and its potential complications. These can include inducing vomiting, providing activated charcoal to limit drug absorption, and performing a procedure known as gastric lavage or stomach pumping to clear the contents of the stomach.Vital signs such as blood pressure, oxygen levels, and heart rate will be monitored, and any occurring symptoms like low blood pressure, dehydration, or kidney problems will be managed. If necessary, tests may be performed to assess liver and kidney function. Close monitoring and management of fluid intake are important to prevent dehydration and manage blood pressure. The medication dosage might be adjusted, and additional medications may be prescribed to treat any complications resulting from the overdose. The specific approach will depend on the individual's current condition and the severity of the overdose.

It is important to take your Irbesartan and Hydrochlorothiazide medication as soon as possible if you miss a dose. If you remember the missed dose close to the time of your next scheduled dose, skip the missed dose altogether. Take your next dose according to the scheduled time instead of doubling the dosage to make up for the missed dose. It is essential to maintain a routine and adhere to the doctor's prescription. It is recommended to consult a medical professional for specific guidance regarding medication and particular situations. If you have any further questions or need additional information, please let me know.

Before starting the medication Irbesartan 300mg and Hydrochlorothiazide 12.5mg, you should read the medication guide provided by your pharmacist. It is important to follow the instructions provided and complete the course of treatment. This medication is taken by mouth with or without food, but it is recommended to take it with food to avoid an upset stomach. It is typically taken once or twice daily as directed by your doctor. For effectiveness in treating high blood pressure, it is important to take it regularly and at the same time each day. Consult a doctor before changing doses, as dosage is dependent on the user's age, medical history, and tolerance to the medication. It is necessary to keep taking this medication even if you feel well unless advised otherwise by your doctor. Stopping the medication without medical consultation may affect its effectiveness. If you miss a dose, take it as soon as possible. If it is near the time of the next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to catch up.

Discerning instances where this medication may not be appropriate:

• Known hypersensitivity to irbesartan, hydrochlorothiazide, or any component of the formulation.
• History of symptomatic hypotension with hydrochlorothiazide or other thiazide diuretics.
• Impaired renal function or kidney failure (eGFR <60 mL/min).
• Sodium retention or fluid overload.
• Dehydration or hypovolaemia.
• Severe liver disease or liver failure.
• Kidney disease (including dialysis patients).
• Hypotension (systolic blood pressure <90 mmHg) without an obvious cause.
• Commencing or discontinuing concomitant medicinal products that have known interactions with Irbesartan/Hydrochlorothiazide (e.g. cyclosporin, carbamazepine, Rifampin).
• During or within 2 weeks of discontinue any other antihypertensive agents.
• History of gout (hydrochlorothiazide can induce gout).
• Features suggestive of terminal renal disease, or severe renal impairment (eGFR <30 mL/min), or in those undergoing chronic renal dialysis.
• Conditions where fluid retention is desirable (e.g., to prevent or treat hypovolaemia or in those with poor tissue perfusion).

Unraveling the side effects lurking behind this medications are as follows:

• Low blood pressure (hypotension)
• Lightheadedness
• Dizziness
• Fluid retention and swelling (edema)
• Increased potassium levels in the blood (hyperkalemia)
• Decreased pulse rate
• Upper respiratory tract infection
• Back pain
• Muscle pain

Storing Irbesartan and Hydrochlorothiazide properly is essential to maintain their quality and potency. Here are some storage guidelines for these medications: