Co-Extor (5/160/25mg) 28 Tablets

The combination of Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg in a single tablet has a synergistic effect on blood pressure control. Hydrochlorothiazide acts as a diuretic, promoting the excretion of sodium and water, which helps to reduce blood volume and lower blood pressure. Valsartan, an angiotensin II receptor blocker, prevents the binding of angiotensin II to its receptors, leading to vasodilation and decreased blood pressure. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, resulting in relaxation of blood vessels and further reduction in blood pressure. Together, these mechanisms work to decrease peripheral resistance, enhance diuresis, and lower blood pressure, thereby managing hypertension effectively.

Hydrochlorothiazide 25mg, Valsartan 160mg, Amlodipine 5mg

Angiotensin II Receptor Blocker, Thiazide Diuretic, Calcium Channel Blocker

Oral

The following are the uses of Hydrochlorothiazide 25mg, Valsartan 160mg, Amlodipine 5mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to lower blood pressure and reduce the risk of heart disease
• Used to manage hypertension when other medications are not effective
• Used to improve blood flow and relax blood vessels
• Used for patients with a combination of hypertension and other cardiovascular issues
• Used to prevent heart attacks, strokes, and kidney problems
• Used as a long-term treatment to maintain consistent blood pressure control
• Used to help patients achieve their target blood pressure goals

To be taken as per doctor's prescription

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In the case of an overdose of Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg Tablets, individuals may experience symptoms such as excessive urination, dizziness, and a significant drop in blood pressure. This combination of medications can lead to severe hypotension, causing fainting or even shock. Other possible effects include irregular heart rhythms, palpitations, and chest pain. Prompt medical intervention is necessary to manage these symptoms and prevent potential complications, emphasizing the importance of seeking emergency care immediately.

In the case of a missed dose of Hydrochlorothiazide 25mg, it is recommended to take the missed dose as soon as you remember, but if it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. For Valsartan 160mg, if a dose is missed, take it as soon as you remember, but if it's almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Regarding Amlodipine 5mg, if a dose is missed, take it as soon as possible, but if it's almost time for the next dose, skip the missed dose and resume your regular dosing interval. It is important to maintain a consistent medication schedule for optimal effectiveness.

To take the Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Following are the conditions/situations when Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg Tablet should not be used:

• Should not be used in patients with a known allergy to any of the components, including Hydrochlorothiazide, Valsartan, or Amlodipine.
• Contraindicated in patients with a history of angioedema (swelling of the face, lips, tongue, or throat) associated with previous use of ACE inhibitors or ARBs (angiotensin receptor blockers).
• Not recommended for individuals with severe renal impairment or those who are anuric (not producing urine).
• Should not be used in patients with severe hepatic impairment or biliary obstruction.
• Contraindicated during pregnancy, especially in the second and third trimesters, as it may cause fetal harm.
• Not suitable for individuals with low blood pressure (hypotension) or those who are experiencing shock or circulatory collapse.
• Should be avoided in patients with a history of severe narrowing of the aortic or mitral valve in the heart (aortic/mitral valve stenosis).
• Contraindicated in patients with a rare condition known as obstructive jaundice.

The side effects of Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Diarrhea or constipation
• Skin rash or itching
• Increased sensitivity to sunlight
• Swelling in the legs or ankles

Following are the precautions and warnings for Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg Tablet:

• This medication is not suitable for individuals with known allergies to any of its components, including hydrochlorothiazide, valsartan, or amlodipine.
• Patients with kidney or liver problems should use this medication with caution and under medical supervision, as dosage adjustments may be necessary.
• Elderly patients may be more sensitive to the effects of this medication, especially dizziness and lightheadedness.
• Avoid activities that require alertness, such as driving or operating heavy machinery, until you know how this medication affects you, as it can cause dizziness.
• Inform your doctor if you have a history of heart disease, as this medication may affect your blood pressure and heart function.
• Do not use potassium supplements or salt substitutes without medical advice while taking this medication.
• This medication may cause dehydration and electrolyte imbalances, especially in hot weather or with excessive sweating; ensure adequate fluid intake.
• Regular monitoring of blood pressure, kidney function, and electrolyte levels is necessary while on this medication.

Following are the drug interactions for Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg Tablet:

• May decrease the elimination of lithium (a mood stabilizer), leading to increased lithium levels and potential toxicity.
• When combined with nonsteroidal anti-inflammatory drugs (NSAIDs), it can reduce the blood pressure-lowering effect of the drug.
• Hydrochlorothiazide may increase blood calcium levels, which should be monitored when used with calcium supplements or antacids containing calcium.
• Valsartan's blood pressure-lowering effect may be reduced by NSAIDs.
• Amlodipine may have an additive effect on blood pressure when used with other antihypertensive medications, requiring close monitoring.
• Grapefruit juice can increase the blood levels of amlodipine, potentially leading to increased side effects.
• Caution is advised when using this combination with other medications that lower blood pressure, as it may cause excessive hypotension.
• It may increase the risk of hyperkalemia (high potassium levels) when used with potassium-sparing diuretics or potassium supplements.

Following are the food interactions to consider with Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg Tablet:

• Avoid excessive salt intake, as Hydrochlorothiazide is a diuretic and can lead to increased sodium excretion, affecting blood pressure control.
• Limit potassium-rich foods like bananas, oranges, and spinach if you have kidney problems, as Hydrochlorothiazide can cause potassium loss.
• Valsartan may increase potassium levels; monitor intake of potassium-rich foods, especially if you have kidney issues.
• Avoid or limit alcohol consumption as it can interact with Amlodipine, increasing the risk of side effects like dizziness and low blood pressure.
• Grapefruit and grapefruit juice should be consumed cautiously as they may affect the metabolism of Valsartan and Amlodipine.
• Maintain a balanced diet low in saturated fats and cholesterol to support cardiovascular health.
• Consult your healthcare provider for personalized dietary recommendations based on your specific health conditions.

Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid extreme temperatures and never store them in the bathroom or near heat sources. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is crucial. Do not dispose of them in wastewater or household waste; consult a pharmacist or healthcare professional for safe disposal options. It is imperative to keep all medications securely stored, out of the reach of children, to prevent accidental ingestion.

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Following are the quick tips for Hydrochlorothiazide 25mg, Valsartan 160mg, and Amlodipine 5mg Tablet:

• Consult your doctor or pharmacist for personalized instructions.
• Take the tablet as directed, typically once daily.
• Consume the tablet with a full glass of water.
• Maintain a consistent schedule for taking your medication.
• Avoid crushing or chewing the tablet; swallow it whole.
• Inform your doctor if you have kidney or liver issues.
• Store the medication in a cool, dry place, away from sunlight.
• Do not share your medication with others, even with similar symptoms.