Co Olesta (20/12.5mg) 10 Tablets

Hydrochlorothiazide and Olmesartan Medoxomil work synergistically in the tablet to lower blood pressure. Hydrochlorothiazide is a diuretic that increases urinary excretion of sodium and chloride, leading to increased water loss and reduced blood volume, which in turn lowers blood pressure. Olmesartan Medoxomil, on the other hand, is an angiotensin II receptor blocker (ARB). It blocks the angiotensin II receptors in the body, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This leads to relaxation of blood vessels, reduced blood pressure, and decreased fluid retention. By combining these two mechanisms, the tablet effectively reduces blood pressure and provides better control over hypertension.

Hydrochlorothiazide 12.5mg, Olmesartan Medoxomil 20mg

Angiotensin II Receptor Blocker and Diuretic

Tablet

The following are the uses of Hydrochlorothiazide 12.5mg, Olmesartan Medoxomil 20mg Tablet:

• Used for controlling high blood pressure
• Used to treat hypertension and lower blood pressure
• Used to reduce the risk of stroke, heart attack, and kidney problems
• Used to manage fluid retention, especially in patients with heart or kidney disease
• Used for improving blood flow and relaxing blood vessels
• Used to prevent the narrowing of blood vessels, promoting better blood circulation
• Used as a long-term treatment option for maintaining cardiovascular health

In the case of an overdose of Hydrochlorothiazide 12.5mg and Olmesartan Medoxomil 20mg tablets, symptoms may include dizziness, hypotension, and electrolyte imbalances. Prompt medical intervention is vital. Patients should be closely monitored for vital signs, and treatment may involve gastric lavage, supportive care, and addressing specific symptoms to prevent further complications. It is important to seek medical advice immediately if an overdose is suspected.

In the case of a missed dose of Hydrochlorothiazide 12.5mg, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. For Olmesartan Medoxomil 20mg Tablet, if you miss a dose, take it as soon as you remember, but if it's close to your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

To take the Hydrochlorothiazide 12.5mg, Olmesartan Medoxomil 20mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Following are the conditions/situations when Hydrochlorothiazide 12.5mg and Olmesartan Medoxomil 20mg Tablet should not be used:

• Should not be used in patients with known allergy or hypersensitivity to Hydrochlorothiazide, Olmesartan, or any other sulfonamide-derived drugs.
• Contraindicated in patients with severe renal impairment or anuria (inability to produce urine).
• Not recommended for individuals with significant liver dysfunction or progressive liver diseases.
• Should not be used during pregnancy, especially in the second and third trimesters, as it can cause harm to the fetus.
• Contraindicated in patients with a history of angioedema (swelling of deep layers of the skin) induced by previous treatment with angiotensin II receptor antagonists.
• Not suitable for individuals with low blood potassium levels (hypokalemia) or low blood sodium levels (hyponatremia) before starting treatment.
• Should be avoided in patients with severe dehydration or those who have recently experienced a significant loss of body fluids.

The side effects of Hydrochlorothiazide 12.5mg and Olmesartan Medoxomil 20mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Electrolyte imbalances (such as low potassium or sodium levels)
• Increased sensitivity to sunlight
• Skin rash or itching
• Gastrointestinal issues (nausea, vomiting, diarrhea)
• Muscle cramps or joint pain
• Increased urination

Following are the precautions and warnings for Hydrochlorothiazide 12.5mg, Olmesartan Medoxomil 20mg Tablet:

• This medication should not be taken by individuals with a known allergy to Hydrochlorothiazide, Olmesartan Medoxomil, or any other ingredients in the tablet.
• Patients with a history of kidney or liver problems should exercise caution and consult their doctor, as dosage adjustments may be necessary.
• Dehydration is a potential risk, so ensure you stay properly hydrated while taking this medication.
• Regular monitoring of blood pressure and kidney function is recommended during treatment.
• It may cause dizziness or lightheadedness, especially when standing up from a sitting or lying position; caution is advised when performing tasks that require alertness.
• This medication may increase sensitivity to sunlight; limit sun exposure and use protective measures when outdoors.
• Inform your doctor about all the medications you are currently taking to avoid potential drug interactions.
• Patients with diabetes should monitor their blood sugar levels regularly as this medication can affect blood glucose control.

Following are the drug interactions for Hydrochlorothiazide 12.5mg, Olmesartan Medoxomil 20mg Tablet:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect of olmesartan and increase the risk of kidney problems.
• Lithium levels in the blood may be increased by thiazide diuretics like hydrochlorothiazide, potentially leading to lithium toxicity.
• The effectiveness of hydrochlorothiazide in lowering blood pressure may be reduced when used with corticosteroids or other drugs that cause fluid retention.
• Caution is advised when combining with diabetes medications, as hydrochlorothiazide can increase blood sugar levels.
• The blood concentration of digoxin may be increased, requiring monitoring and dose adjustments.
• Cholesterol-lowering medications (bile acid sequestrants) may reduce the absorption of hydrochlorothiazide.
• Olmesartan's blood pressure-lowering effect may be reduced by non-steroidal anti-inflammatory drugs (NSAIDs).

Following are the food interactions for Hydrochlorothiazide 12.5mg and Olmesartan Medoxomil 20mg Tablet:

• Avoid excessive salt (sodium) intake, as Hydrochlorothiazide is a diuretic and can increase sodium loss, leading to electrolyte imbalances.
• Potassium-rich foods like bananas, oranges, and spinach are recommended to maintain potassium levels, as Hydrochlorothiazide may cause potassium depletion.
• Limit alcohol consumption as it can increase the risk of dizziness and lightheadedness, especially with Olmesartan.
• Grapefruit and grapefruit juice should be avoided as they may affect the metabolism of Olmesartan, potentially increasing blood levels and side effects.
• Maintain a balanced diet, as Olmesartan may cause elevated potassium levels in some individuals, and certain foods like dairy and potassium-rich foods may need to be monitored.
• Avoid high-fat meals as they can affect the absorption and effectiveness of Olmesartan.
• Stay well-hydrated, especially when engaging in strenuous activities, as Hydrochlorothiazide can increase urine output.

Hydrochlorothiazide 12.5mg, Olmesartan Medoxomil 20mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to keep the medication away from heat sources like radiators or stoves, as temperature fluctuations can impact its effectiveness. Proper disposal is essential; do not flush or pour it down the drain. Consult a pharmacist or healthcare professional for guidance on safe disposal methods. Always keep medicines out of children's reach to prevent accidental consumption. Remember to adhere to local regulations regarding medication disposal to ensure environmental responsibility.

Following are the quick tips for Hydrochlorothiazide 12.5mg and Olmesartan Medoxomil 20mg Tablet:

• Take the medication as directed by your doctor, usually once daily.
• Ensure you stay well-hydrated while taking this medication.
• It is best to take this medication at the same time each day to maintain a consistent level in your body.
• Avoid salt substitutes or potassium supplements unless advised by your doctor.
• Regularly monitor your blood pressure and kidney function as advised by your healthcare provider.
• Do not double the dose to make up for a missed one; continue with the regular dosing schedule.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.