CODIBON DROPS 10ML

Cholecalciferol, also known as vitamin D3, primarily exerts its effects by undergoing a series of metabolic conversions in the body. Once absorbed, cholecalciferol is converted in the liver to 25-hydroxyvitamin D, which is further metabolized in the kidneys to its active form, 1,25-dihydroxyvitamin D (calcitriol). Calcitriol binds to specific vitamin D receptors (VDRs) found in various tissues, including the intestines, bones, and kidneys. This binding triggers a cascade of intracellular events, leading to the regulation of gene expression. In the intestines, it enhances the absorption of calcium and phosphorus, promoting bone mineralization. In the kidneys, it regulates calcium and phosphate reabsorption, maintaining calcium homeostasis. Additionally, cholecalciferol influences immune function and cell proliferation through its effects on gene expression, highlighting its diverse roles in maintaining overall health.

Cholecalciferol 40iu

vitamin D analogue class.

Drop

The following are the uses of Cholecalciferol 40iu Drop:

• Used for treating and preventing vitamin D deficiency, ensuring healthy bone development and preventing conditions like rickets.
• Used for promoting calcium absorption in the gut, vital for maintaining strong bones and teeth.
• Used for regulating phosphate levels, which is crucial for overall bone health and muscle function.
• Used for supporting immune function, as vitamin D plays a role in activating immune cells.
• Used for reducing the risk of respiratory infections, especially in individuals with vitamin D deficiency.
• Used for improving muscle strength and reducing the risk of falls, particularly in older adults.
• Used for enhancing mood and cognitive function, as vitamin D receptors are present in brain tissue.

In the case of an overdose of Cholecalciferol 40iu Drops, it is important to recognize the potential symptoms and seek medical advice promptly. Overdosing on this medication may lead to an excessive intake of vitamin D, resulting in symptoms such as nausea, vomiting, weakness, and increased thirst and urination. It is crucial to consult a healthcare professional or a poison control center for guidance on managing the overdose and preventing potential complications.

In the case of a missed dose of Cholecalciferol 40iu Drop, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for advice on how to get back on track with your treatment plan. It is recommended to store the medication properly and set reminders to ensure timely administration of the drops.

To administer Cholecalciferol 40iu Drops, gently squeeze the desired number of drops (as prescribed) under the tongue and hold them there for a brief moment to allow for absorption before swallowing.

Following are the conditions when Cholecalciferol 40iu Drop should not be used:

• Allergic reaction Should not be used if you have a known or suspected allergy to Cholecalciferol or any of its inactive ingredients.
• Vitamin D toxicity Contraindicated in individuals with high levels of vitamin D or hypercalcemia (high calcium levels in the blood).
• Kidney disease Not recommended for patients with severe kidney problems as it can affect calcium metabolism.
• Hypervitaminosis D Should not be used in people with conditions causing excessive vitamin D levels.
• Malabsorption syndromes Contraindicated in patients with conditions that impair vitamin D absorption, such as cystic fibrosis or short bowel syndrome.
• Hypercalcemia Should not be used in individuals with conditions causing high calcium levels, such as primary hyperparathyroidism.
• Sarcoidosis Not suitable for patients with active sarcoidosis, as it can lead to excessive calcium absorption.

The side effects of Cholecalciferol 40iu Drop may include:

• Nausea and vomiting
• Constipation or diarrhea
• Dry mouth
• Metallic taste
• Fatigue and weakness
• Muscle or joint pain
• Increased calcium levels in the blood (hypercalcemia), leading to potential issues like kidney problems.

Following are the precautions and warnings for Cholecalciferol 40iu Drop:

• Avoid taking high doses of Vitamin D without medical supervision, as it may lead to hypervitaminosis D.
• Regular monitoring of calcium and phosphate levels is recommended during long-term use.
• Patients with kidney disease, hyperparathyroidism, sarcoidosis, or any condition affecting calcium metabolism should use this medication with caution.
• Not recommended for individuals with a history of hypercalcemia or conditions that increase the risk of hypercalcemia.
• If you have a history of kidney stones, use this medication with caution and under medical supervision.
• Keep out of reach of children. Accidental overdose may cause serious side effects.
• Consult a healthcare professional before using this medication if you are pregnant, breastfeeding, or planning to become pregnant.

Following are the drug interactions for Cholecalciferol 40iu Drop:

• It may decrease the effectiveness of thiazide diuretics and digoxin, requiring dosage adjustments.
• Cholestyramine and colestipol can reduce the absorption of cholecalciferol, so it's best to take the vitamin at least 1 hour before or 4 to 6 hours after these medications.
• Anticonvulsants like phenobarbital and phenytoin can accelerate the metabolism of vitamin D, requiring higher doses to maintain adequate levels.
• Orlistat and cholestyramine can reduce the absorption of vitamin D, potentially leading to lower blood levels.
• Corticosteroids like prednisone may increase vitamin D requirements, as they can affect bone metabolism.
• Aluminum-containing antacids can decrease the absorption of vitamin D, so it's best to take them at different times.
• Drugs that induce CYP3A4 enzymes, such as carbamazepine and rifampin, may decrease vitamin D levels by enhancing its metabolism.

Following are the food interactions for Cholecalciferol 40iu Drop:

• Avoid excessive consumption of vitamin D-fortified foods like dairy products, cereals, and juices as they may lead to an overdose when combined with the supplement.
• Limit the intake of fatty fish like salmon, mackerel, and tuna, as they are naturally rich in vitamin D, and excessive intake alongside the supplement may result in vitamin D toxicity.
• Restrict the use of cod liver oil and other fish liver oils, as they are high in vitamin D and can increase the risk of hypervitaminosis D.
• Avoid high-dose vitamin D supplements in combination with this medication unless advised by your healthcare provider.
• Grapefruit and grapefruit juice should be consumed in moderation as they may interfere with vitamin D metabolism.
• Maintain a balanced diet and ensure you're not consuming excessive amounts of vitamin D-rich foods to prevent adverse effects.
• Alcohol may decrease the absorption of fat-soluble vitamins like vitamin D, so moderate alcohol consumption is advised.
• Always consult a healthcare professional for personalized advice regarding diet and medication interactions.

Cholecalciferol 40iu Drop should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Keep the medication securely sealed in its original container to maintain its integrity and prevent contamination. Avoid exposing the drop to extreme temperatures by not storing it in the bathroom or near heat sources like ovens or heaters. Regularly check the expiration date, and if the medication is no longer needed or has expired, dispose of it responsibly. Proper disposal is crucial; do not flush it down the toilet or pour it into any water source. Consult your pharmacist or healthcare professional for guidance on safe disposal methods. Remember to keep all medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Cholecalciferol 40iu Drop:

• Consult your healthcare provider to determine the appropriate dosage for your specific needs.
• Administer the drops directly into the mouth or mix with a small amount of food or drink as directed.
• Store the drops in a cool, dry place away from direct sunlight and moisture.
• Ensure the dropper is clean and avoid touching it to prevent contamination.
• Always check the expiration date before using the drops.
• Avoid taking double doses; if you miss a dose, take it as soon as you remember, unless it's almost time for the next dose.
• Inform your doctor about all medications and supplements you are taking to prevent potential interactions.
• Regularly monitor vitamin D levels and adjust dosage as advised by your healthcare provider.