CODLI AD CAP

Calcifediol, also known as 25-hydroxyvitamin D, is a precursor to the active form of vitamin D in the body. Its mechanism of action involves promoting calcium absorption in the intestines, maintaining adequate serum calcium and phosphate concentrations, and promoting bone mineralization. Calcifediol is converted in the kidneys to calcitriol, the active form of vitamin D, which then binds to vitamin D receptors in target cells, regulating gene expression and influencing various physiological processes related to calcium and bone homeostasis. Retinol, or Vitamin A, plays a crucial role in vision, immune function, and cellular differentiation. It acts through its active metabolite, retinoic acid, which binds to retinoic acid receptors in the cell nucleus, regulating gene expression and influencing cellular growth, differentiation, and immune responses.

Calcifediol 60, Retinol (Vitamin A) [ 600 IU]

Vitamin D analog

Capsule

The following are the uses of Calcifediol 60, Retinol (Vitamin A) [ 600 IU] Capsule:

• Used for treating Vitamin D deficiency
• Used to support bone health and calcium absorption
• Used for improving skin conditions like acne and eczema
• Used to enhance eye health and vision
• Used for strengthening the immune system
• Used for promoting healthy cell growth and development
• Used to support overall well-being and prevent deficiencies

In the case of an overdose of Calcifediol 60, immediate symptoms may include nausea, vomiting, and a metallic taste in the mouth. Prolonged or severe overdoses can lead to hypercalcemia, characterized by excessive thirst, frequent urination, muscle weakness, and bone pain. Retinol (Vitamin A) overdose can cause symptoms like dizziness, headache, and skin irritation. If either of these overdoses is suspected, seek medical advice promptly to ensure appropriate treatment and prevent potential complications.

In the case of a missed dose of Calcifediol 60, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. For Retinol (Vitamin A) 600 IU Capsule, if you forget to take a dose, take it as soon as you remember, and then adjust the timing of your next dose accordingly. If it's closer to the time of your next scheduled dose, skip the missed dose and resume your regular dosing routine.

To take Calcifediol 60 and Retinol (Vitamin A) [600 IU] Capsule, swallow the capsule whole with a glass of water, preferably with a meal or as directed by your healthcare provider, once daily or as instructed by your doctor.

Following are the conditions when Calcifediol 60, Retinol (Vitamin A) [600 IU] Capsule should not be used:

• Avoid if you have a known allergy or hypersensitivity to Calcifediol, Retinol, or any of the excipients in the formulation.
• Do not take if you have hypervitaminosis A (excessive Vitamin A levels in the body).
• Should not be used in individuals with impaired liver function or active liver disease.
• Contraindicated in people with hypercalcemia (high calcium levels in the blood).
• Avoid if you have a history of kidney stones or are at risk of developing kidney problems.
• Not suitable for individuals with a history of hypercalciuria (high calcium levels in urine).
• Do not use if you have a blockage in your intestines or any conditions that impair fat absorption.
• Should not be used in patients with a history of arterial thrombosis or thromboembolic disease.

The side effects of Calcifediol 60, Retinol (Vitamin A) [600 IU] Capsule may include:

• Nausea and vomiting
• Dry mouth
• Skin irritation or rash
• Increased sensitivity to sunlight
• Hair loss or changes in hair texture
• Joint or muscle pain
• Elevated calcium levels in the blood (hypercalcemia)
• Allergic reactions (e.g., itching, swelling, difficulty breathing)

Following are the precautions and warnings for Calcifediol 60, Retinol (Vitamin A) [600 IU] Capsule:

• Avoid if allergic to calcifediol, vitamin D, or any of the capsule's components.
• Exercise caution in patients with a history of kidney disease, as dosage adjustments might be necessary.
• Vitamin A (Retinol) may cause drowsiness; avoid driving or operating heavy machinery until you know how it affects you.
• Consult a doctor if you have any underlying medical conditions or are taking other medications.
• Do not exceed the recommended dosage, as excessive vitamin A intake can lead to hypervitaminosis A.
• Pregnant and breastfeeding women should consult their healthcare provider before use, as high doses of vitamin A can be harmful to the fetus and infant.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Calcifediol 60 and Retinol (Vitamin A) [600 IU] Capsule:

• Calcifediol may interact with antacids containing magnesium, aluminum, or calcium, as these can reduce its absorption. It is recommended to take Calcifediol at least 2 hours before or 4 hours after taking these antacids.
• Retinol (Vitamin A) can interact with certain medications like isotretinoin and acitretin, potentially leading to increased risk of vitamin A toxicity.
• Vitamin A supplements should be used cautiously with certain medications like orlistat, which may reduce the absorption of fat-soluble vitamins.
• Tetracycline antibiotics may decrease the effectiveness of vitamin A, and it is advised to separate their administration by several hours.
• Vitamin A may interact with warfarin, increasing the risk of bleeding. Monitoring of INR (International Normalized Ratio) is advised.
• Retinol can enhance the toxicity of certain medications like methotrexate and etretinate, and concurrent use should be avoided.
• Caution is advised when using Calcifediol in patients taking digoxin, as it may increase calcium levels and potentially affect digoxin's effectiveness.

Following are the food interactions for Calcifediol 60 and Retinol (Vitamin A) Capsule:

• High-fat meals may delay the absorption of Vitamin A, so it is advisable to take the capsule on an empty stomach or with a low-fat meal.
• Vitamin A can be found in various foods, especially liver, fish oil, and certain fortified products. Avoid excessive consumption of these foods while taking the capsule to prevent Vitamin A toxicity.
• Calcifediol may interact with calcium-rich foods like dairy products, leafy greens, and fortified foods. Monitor calcium intake to ensure it remains within healthy limits.
• Foods rich in Vitamin D, such as fatty fish, egg yolks, and fortified dairy products, may lead to an increased risk of Vitamin D toxicity when combined with Calcifediol.
• Grapefruit and grapefruit juice should be consumed cautiously as they can affect drug metabolism, potentially altering the effectiveness of both Calcifediol and Retinol.
• Alcohol may interfere with Vitamin A absorption and increase the risk of liver damage, especially with long-term use.
• Limit caffeine intake as it may interfere with Vitamin A absorption and potentially increase the risk of side effects.
• Avoid excessive consumption of antioxidants like Vitamin C and E supplements, as they may affect the absorption and metabolism of both vitamins.

Storage and disposal of Calcifediol 60 and Retinol (Vitamin A) [600 IU] Capsules require attention to ensure their effectiveness and safety. Store these capsules in a cool, dry place, away from sunlight and moisture, preferably in their original container with the lid tightly secured. Maintain a consistent room temperature, avoiding exposure to heat sources like stoves or radiators. Regularly check the expiration date, and never use the capsules beyond this date. When disposing of unused or expired medication, do not flush or pour them down the drain. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to prevent environmental contamination. Keep the capsules out of children's reach to prevent accidental ingestion.

Following are the quick tips for Calcifediol 60, Retinol (Vitamin A) [600 IU] Capsule:

• Consult your healthcare provider for the right dosage based on your medical condition.
• Take the capsule as directed; do not crush or chew.
• Ensure a consistent supply by refilling your prescription on time.
• Store the capsules in a cool, dry place, away from sunlight.
• Do not share your medication with others, even with similar symptoms.
• Inform your doctor about all the medications you are taking.
• Contact your healthcare provider if you experience any vision changes or persistent side effects.
• Maintain a balanced diet rich in Vitamin A sources like carrots, sweet potatoes, and leafy greens.