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Colchicine (0.5mg) 100 Tablets
- Manufacturer Howards Pharma
- Generic Name Colchicine
Healthwire Pharmacy Ratings & Reviews (1500+)
Product Information
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Description
Colchicine disrupts microtubule formation by binding to tubulin, which inhibits leukocyte migration and phagocytosis. This reduces inflammation and decreases the accumulation of inflammatory cells, particularly effective in treating gout by decreasing the inflammatory response to uric acid crystals.
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Ingredients
Colchicine -
Drug Class
Antigout agent
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Dosage Form
Tablet -
Uses
Colchicine is used for:
- Gout Attacks
- Familial Mediterranean Fever
- Prevention of Gout Flares
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Dosage
Colchicine dosage for the indication of gout and familial Mediterranean fever, with long-term prevention:
- Adults - 0.5-1 mg once or twice daily.
- Children - Not recommended.
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In case of Overdose
Overdose may cause severe gastrointestinal and renal issues. Seek medical help urgently.
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Missed Dose
If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.
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How To Use
Taken orally, usually in divided doses. Follow the prescribed dosage and frequency.
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When Not to Use
Colchicine should not be used if:
- Hypersensitivity
- Severe renal or hepatic impairment
- Pregnant
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Side Effects
Possible side effects of Colchicine include:
- Gastrointestinal upset
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
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Precautions & Warnings
The warnings and precautions associated with Colchicine are:
- Patient with CV disease or gastrointestinal disorders.
- Abnormalities in blood counts.
- Debilitated patients.
- Not indicated as an analgesic for other causes of pain.
- Concomitant use with P-gp inhibitors and moderate or strong CYP3A4 inhibitors (with normal renal and hepatic function).
- Mild to moderate renal and hepatic impairment (for acute gout).
- Renal and hepatic impairment (for familial Mediterranean fever).
- Children (for familial Mediterranean fever) and elderly.
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Drug Interactions
The drug interactions with colchicine include:
- CYP3A4 Inhibitors – Can increase colchicine levels.
- P-glycoprotein Inhibitors – Can increase colchicine levels.
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Food Interactions
For Colchicine, food interactions that should be considered are:
- Avoid consuming alcohol and high-fat meals as they may increase the risk of gastrointestinal side effects.
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Storage/Disposal
Colchicine should be stored at room temperature, away from light and moisture. Keep it in its original container and out of reach of children. Dispose of expired or unused Colchicine according to local disposal guidelines or use a drug take-back program.
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