Coldene-P 100 Tablets

Pheniramine maleate, an antihistamine, works by blocking H1-receptor sites, preventing histamine binding and subsequent cellular effects. This action reduces histamine-induced symptoms like itching, sneezing, and hives. Paracetamol (acetaminophen) in this combination acts as an analgesic and antipyretic. It inhibits cyclooxygenase (COX) enzymes, particularly in the central nervous system, reducing prostaglandin production and thereby decreasing pain and fever.

Antihistamine, Analgesic.

Tablet

The following are the uses of Pheniramine Maleate, Paracetamol Tablet:

• Used for relieving symptoms of the common cold, allergies, and hay fever.
• Used for reducing fever and providing pain relief.
• Used for treating mild to moderate pain, including headaches, toothaches, and post-vaccination discomfort.
• Used for alleviating discomfort from minor aches and pains.
• Used for managing symptoms of upper respiratory tract infections.
• Used for addressing sinus pain and congestion.
• Used for providing short-term relief from allergic reactions and skin itching.

In the case of an overdose of Pheniramine Maleate and Paracetamol Tablets, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and in severe cases, liver damage or failure. Prompt medical attention is necessary, as doctors may induce vomiting or administer activated charcoal to prevent further absorption of the medication. Treatment focuses on managing symptoms and providing supportive care to minimize potential harm to the liver and other organs.

In the case of a missed dose of Pheniramine Maleate and Paracetamol Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for the missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Always consult your healthcare provider if you have any concerns or questions about managing missed doses.

To take Pheniramine Maleate and Paracetamol Tablets, swallow the tablet whole with a glass of water, preferably after a meal, following the dosage instructions provided by your healthcare professional, typically one tablet every 4 to 6 hours, or as directed on the medication label.

Here are the conditions or situations when Pheniramine Maleate, Paracetamol Tablet should not be taken:

• Avoid using this medication if you have a known allergy or hypersensitivity to Pheniramine Maleate or Paracetamol (Acetaminophen).
• Do not take this medication if you are currently taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days.
• Contraindicated in patients with narrow-angle glaucoma.
• Should not be used in individuals with severe liver impairment or active liver disease.
• Avoid using this medication if you have a breathing problem or chronic obstructive pulmonary disease (COPD).
• Not suitable for patients with a history of seizures or epilepsy.
• Do not take this medication if you have difficulty in urination due to an enlarged prostate or any other urinary retention issues.
• Should be avoided in individuals with gastrointestinal obstruction or severe constipation.
• Contraindicated during the last trimester of pregnancy as it may cause fetal harm.

The side effects of Pheniramine Maleate, Paracetamol Tablet may include:

• Drowsiness or sleepiness
• Dry mouth
• Nausea and vomiting
• Constipation or diarrhea
• Blurred vision
• Dizziness or lightheadedness
• Increased sensitivity to sunlight
• Skin rash or itching

Following are the precautions and warnings for Pheniramine Maleate, Paracetamol Tablet:

• Avoid using this medication if you are allergic to any of its ingredients, including pheniramine maleate and paracetamol.
• This medication may cause drowsiness and dizziness, so refrain from driving or operating heavy machinery until you know how it affects you.
• Alcohol consumption should be avoided as it can increase the risk of liver damage when combined with paracetamol.
• Patients with liver or kidney disease should exercise caution and consult a healthcare professional before use, as the dosage may need adjustment.
• Do not exceed the recommended dosage, as excessive use of paracetamol can lead to severe liver damage.
• If you are taking other medications, especially those with similar ingredients, consult your doctor to prevent potential drug interactions.
• Pregnant and breastfeeding women should seek medical advice before taking this medication to ensure the safety of the fetus or infant.
• Keep this medication out of reach of children to prevent accidental ingestion.

Following are the drug interactions for Pheniramine Maleate and Paracetamol Tablet:

• Alcohol and other central nervous system (CNS) depressants, such as benzodiazepines or opioids, can increase the sedative effects of Pheniramine Maleate, leading to excessive drowsiness.
• Paracetamol may prolong the effects of warfarin and other anticoagulants, requiring close monitoring of INR (International Normalized Ratio) levels.
• It can interact with other antihistamines, intensifying their side effects, including drowsiness and dry mouth.
• The Tablet may reduce the effectiveness of certain antihypertensive medications, requiring close blood pressure monitoring.
• When taken with Metoclopramide, Pheniramine Maleate may decrease its effectiveness in treating gastrointestinal issues.
• Paracetamol can potentially increase the risk of liver damage when used with other potentially hepatotoxic drugs.
• Caution is advised when using with certain antidepressants, as it may increase the risk of serotonin syndrome.

Following are the food interactions for Pheniramine Maleate and Paracetamol Tablet:

• Grapefruit and grapefruit juice should be avoided as they can inhibit the enzyme CYP2C9, potentially affecting the metabolism of Paracetamol and increasing the risk of liver damage with prolonged use.
• Alcohol consumption should be limited as Paracetamol is primarily metabolized by the liver, and excessive alcohol can increase the risk of liver damage, especially with regular use.
• Avoid high-fat meals as Pheniramine Maleate absorption can be affected, leading to reduced effectiveness.
• Caffeine intake should be monitored as it can enhance the nervous system effects of Pheniramine Maleate, potentially causing increased drowsiness or dizziness.
• Spicy foods may increase the risk of stomach irritation, especially when taking Paracetamol regularly.
• Avoid excessive amounts of Vitamin C-rich foods as they can enhance iron absorption, which may interact with Paracetamol's effects.
• Consuming a balanced diet is essential to support the overall effectiveness of the medication and maintain general health.
• Always consult your healthcare provider for personalized advice regarding dietary considerations and potential interactions.

Pheniramine Maleate, Paracetamol Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, moisture, and heat sources like ovens or radiators. It is crucial to maintain the integrity of the medication by keeping it in its original, tightly sealed container, preventing contamination. Regularly check the expiration date, and when disposing of the tablets, avoid flushing them or pouring them down the drain. Instead, seek guidance from a pharmacist or healthcare professional for appropriate disposal methods. Additionally, keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Pheniramine Maleate and Paracetamol Tablet:

• Consult a doctor for proper dosage instructions based on your medical condition.
• Take the tablet as directed, ensuring you follow the prescribed dosage and duration.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain a fixed schedule for taking the medicine for better effectiveness.
• Avoid alcohol consumption as it may intensify side effects.
• Inform your doctor about all medications you are currently taking to prevent any interactions.
• Store the tablets at room temperature, away from moisture and direct sunlight.