COLIFOAM ENEMA IMP

Hydrocortisone, a synthetic corticosteroid, exerts its therapeutic effects primarily by mimicking the actions of endogenous glucocorticoids. When applied topically, it readily penetrates the skin, where it binds to intracellular glucocorticoid receptors in target cells. This binding induces a conformational change in the receptor, leading to the formation of active complexes that then translocate to the cell nucleus. Within the nucleus, these complexes regulate gene expression by interacting with specific DNA sequences, resulting in the modulation of various genes involved in inflammation and immune responses. The anti-inflammatory effects of hydrocortisone are attributed to its ability to inhibit the production and release of pro-inflammatory mediators, such as prostaglandins, leukotrienes, and cytokines, thereby reducing inflammation, itching, and allergic reactions.

Hydrocortisone

Corticosteroid

Liquid

The following are the uses of Hydrocortisone Liquid:

• Used for treating skin inflammation and itching caused by various skin conditions like eczema, dermatitis, and allergic reactions.
• Used for reducing redness, swelling, and discomfort in minor skin injuries.
• Used to manage skin irritation after insect bites or stings.
• Used for providing relief from mild skin rashes and irritations.
• Used to treat mild nappy rash in infants.
• Used for soothing and healing skin after sunburn.
• Used to alleviate itching and inflammation due to mild skin infections.
• Used as a short-term treatment for various skin issues as directed by a healthcare professional.

In the case of an overdose of Hydrocortisone Liquid, it is important to recognize the signs and take appropriate action. Symptoms may include increased thirst, frequent urination, weight gain, and mood changes. If you suspect an overdose, seek medical advice promptly. Treatment may involve supportive care and managing symptoms, ensuring the individual receives the necessary medical attention and monitoring. Always follow the prescribed dosage to prevent such incidents.

In the case of a missed dose of Hydrocortisone Liquid, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may need to adjust your dosage or provide specific instructions to ensure the medication's effectiveness. Always keep a consistent dosing routine to maximize the benefits of Hydrocortisone Liquid.

To take Hydrocortisone Liquid, measure the prescribed dose using an oral syringe or measuring cup, and administer it directly into the mouth, ensuring you follow the dosing instructions provided by your healthcare professional or as directed on the medication label.

Here are the conditions and situations when Hydrocortisone Liquid should not be used:

• Do not use if you have a known allergy or hypersensitivity to hydrocortisone or any of the other ingredients in the liquid formulation.
• Avoid using if you have certain infections, particularly fungal infections, as corticosteroids can worsen these conditions.
• Do not use if you have untreated tuberculosis.
• Not suitable for individuals with systemic fungal infections.
• Should not be used in patients with recent or active gastrointestinal ulcers.
• Avoid using if you have severe liver impairment, as hydrocortisone can affect liver function.
• Not recommended for patients with recent or impending surgery, as it can interfere with wound healing.
• Do not use if you have a viral infection, such as chickenpox or measles, as it can worsen these conditions.
• Contraindicated in patients with certain eye conditions, such as glaucoma or cataracts.
• Should not be used to treat certain skin conditions, such as rosacea, acne, or perioral dermatitis.

The side effects of Hydrocortisone Liquid may include:

• Increased appetite and weight gain
• Nausea and stomach upset
• Headaches or dizziness
• Mood changes, including feeling anxious or depressed
• Difficulty sleeping (insomnia)
• Skin thinning or bruising
• Delayed wound healing
• Elevated blood sugar levels

Following are the precautions and warnings for Hydrocortisone Liquid:

• Avoid contact with eyes, nose, mouth, and other mucous membranes. If accidental contact occurs, rinse thoroughly with water.
• Do not use on large areas of the body or for an extended period without medical supervision, especially in children.
• Wash hands thoroughly after application to avoid accidental transfer to other areas.
• Do not use under occlusive dressings or bandages unless directed by a healthcare professional.
• Do not use on broken or infected skin, or in areas with acne, rosacea, or perioral dermatitis.
• Stop using and consult a doctor if symptoms worsen, or if new symptoms such as itching, redness, or swelling occur.
• Keep out of reach of children. Store at room temperature, away from heat and direct light.

Following are the drug interactions for Hydrocortisone Liquid:

• Avoid combining with potassium-depleting diuretics, as it may lead to hypokalemia.
• May increase blood pressure when used with non-steroidal anti-inflammatory drugs (NSAIDs).
• Concomitant use with antidiabetic medications may require adjustments in dosage due to altered glucose tolerance.
• Hydrocortisone can decrease the effects of anticoagulants like warfarin, requiring close monitoring.
• Drugs metabolized by the liver, such as phenytoin or rifampin, may have reduced efficacy when taken with Hydrocortisone.
• May increase the risk of side effects when used with heart failure medications like digoxin.
• The effects of immunosuppressants can be reduced by Hydrocortisone, potentially impacting treatment outcomes.

Following are the food interactions to consider with Hydrocortisone Liquid:

• Avoid excessive salt intake, as Hydrocortisone can cause sodium retention, leading to increased blood pressure.
• Limit or avoid grapefruit and grapefruit juice, as they may affect the medication's metabolism and increase the risk of side effects.
• Alcohol consumption can increase the risk of gastrointestinal issues and may interfere with the medication's effectiveness.
• Avoid high-sugar foods and beverages, as Hydrocortisone can increase blood sugar levels, especially in diabetic patients.
• Monitor potassium-rich foods like bananas, oranges, and spinach, as Hydrocortisone can cause potassium loss in some cases.
• Calcium-rich foods like dairy products may need to be adjusted, as Hydrocortisone can impact calcium absorption.
• Always follow healthcare provider's advice on dietary restrictions, especially when using Hydrocortisone for extended periods.

Hydrocortisone Liquid should be stored at room temperature, preferably between 68°F and 77°F (20°C and 25°C), in a dry place away from direct sunlight and moisture. Keep the medication in its original container tightly sealed to maintain its integrity and prevent contamination. Avoid storing it in the bathroom or near heat-emitting appliances to prevent degradation. Regularly check the expiration date, and dispose of any unused or expired liquid responsibly, avoiding flushing or pouring it down the drain. Consult your pharmacist or healthcare professional for safe disposal practices. Keep the medication securely stored and out of the reach of children to prevent accidental ingestion.

Following are the quick tips for Hydrocortisone Liquid:

• Store the liquid at room temperature, away from direct sunlight and moisture.
• Check the expiry date before using, and do not use if it has expired.
• Use an accurate measuring device to ensure the correct dose.
• Swish the liquid in your mouth for a while before swallowing to enhance absorption.
• Avoid smoking and alcohol consumption while using the liquid for better effectiveness.
• Inform your doctor about any other medications you are taking to prevent potential interactions.
• Seek medical advice if symptoms persist or worsen after using the liquid.