COLISTIM 80MG INJ

Colistimethate sodium, upon administration, is rapidly converted to colistin, which is the active form. Colistin primarily acts by disrupting the integrity of the bacterial cell membrane. It binds to lipopolysaccharides in the outer membrane of Gram-negative bacteria, displacing bacterial counterions like calcium and magnesium. This leads to membrane destabilization and increased permeability, allowing colistin to penetrate the cell. Once inside, colistin binds to lipopolysaccharides in the inner membrane, causing further disruption and leakage of intracellular contents, ultimately leading to bacterial cell death. The bactericidal activity of colistimethate sodium is concentration-dependent, with higher concentrations being more effective against susceptible bacteria.

Polymyxin antibiotic

Injection

The following are the uses of colistimethate sodium 80MG Injection:

• Used for treating severe infections caused by multidrug-resistant bacteria, especially in cases of pneumonia and abdominal infections.
• Used for combating bacterial infections in patients with cystic fibrosis, ensuring effective treatment.
• Used for managing chronic lung infections in individuals with bronchiectasis, improving respiratory health.
• Used for treating complicated urinary tract infections that are resistant to other antibiotics.
• Used for controlling skin and soft tissue infections, including those related to burns or wounds.
• Used for preventing and treating infections in patients undergoing surgery or invasive procedures.
• Used for its ability to combat a wide range of bacterial pathogens, providing a powerful defense against severe infections.

In the case of an overdose of Colistimethate Sodium 80MG Injection, individuals may experience heightened adverse effects associated with the medication. These effects can include severe kidney damage, as the kidneys play a vital role in metabolizing the drug. Additionally, neurological symptoms such as dizziness, headache, and confusion may manifest. Prompt medical intervention is essential to manage these symptoms and prevent further complications. It is crucial to seek professional medical advice in the event of an overdose.

In the case of a missed dose of Colistimethate Sodium 80MG Injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one. If you miss multiple doses, contact your healthcare professional for guidance on how to resume the medication safely. Always consult your doctor or pharmacist if you have any concerns or questions regarding missed doses.

To administer Colistimethate Sodium 80MG Injection, prepare the medication by drawing the prescribed dose into a syringe, ensuring it is free of air bubbles, and inject it intramuscularly or intravenously as directed by your healthcare provider, following the prescribed dosage and administration schedule provided.

Here are the conditions and situations when Colistimethate Sodium 80mg Injection should not be used:

• Must not be administered to individuals with a known allergy to Colistimethate Sodium or any other components in the injection.
• Contraindicated in patients with a history of myasthenia gravis.
• Not suitable for patients with known neuromuscular disorders.
• Should not be used in patients with kidney disease or those on hemodialysis.
• Contraindicated during pregnancy, especially in the first trimester.
• Not recommended for nursing mothers due to potential risks to the infant.
• Should be avoided in patients with a history of hypersensitivity reactions to other aminoglycoside antibiotics.
• Must not be used in patients with hearing impairments or those with a history of hearing loss.
• Contraindicated in patients with Parkinson's disease.

The side effects of colistimethate sodium 80MG Injection may include:

• Nausea and vomiting
• Diarrhea
• Skin rashes or itching
• Muscle weakness or pain
• Hearing loss or ringing in the ears (tinnitus)
• Kidney problems (increased creatinine levels)
• Nerve damage (neurotoxicity)
• Allergic reactions (e.g., difficulty breathing, hives)

Following are the precautions and warnings for Colistimethate Sodium 80MG Injection:

• This medication is intended for intravenous use only and should be administered by trained healthcare professionals.
• Patients with a known allergy to colistimethate sodium or any of its components should not receive this injection.
• Renal function should be closely monitored during treatment, especially in patients with pre-existing kidney issues.
• Caution is advised in patients with neuromuscular disorders, as colistimethate sodium may exacerbate muscle weakness.
• It may cause nerve damage, so patients should be monitored for symptoms like muscle weakness, tingling, or numbness.
• Elderly patients may be more susceptible to the side effects, particularly kidney-related issues.
• Pregnant and breastfeeding women should only use this medication if the potential benefits outweigh the risks.
• It should be used with caution in patients with myasthenia gravis or other neuromuscular diseases.

Following are the drug interactions for Colistimethate Sodium 80mg Injection:

• Neuromuscular blocking agents may prolong the neuromuscular block, especially in patients with renal impairment.
• Concomitant use with other nephrotoxic drugs (e.g., aminoglycosides, vancomycin) may increase the risk of kidney damage.
• Colistimethate sodium can interact with other antibiotics like polymyxin B, potentially increasing the risk of neurotoxicity and nephrotoxicity.
• The effectiveness of live attenuated vaccines may be reduced during and for several months after treatment with colistimethate sodium.
• May enhance the anticoagulant effect of anticoagulants like warfarin, requiring close monitoring of coagulation parameters.
• Caution with drugs that affect renal function, as colistimethate sodium is primarily eliminated through the kidneys.
• Certain diuretics may increase the risk of ototoxicity when used with colistimethate sodium.

Following are the food interactions for Colistimethate Sodium 80MG Injection:

• Avoid consuming high-fat meals as they may interfere with the absorption of colistimethate sodium, potentially reducing its effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the drug, leading to increased blood levels and potential toxicity.
• Alcohol intake should be limited as it may increase the risk of kidney-related side effects associated with colistimethate sodium.
• Caffeine-rich foods and beverages may enhance the effects of colistimethate sodium on the nervous system, potentially causing increased jitteriness or nervousness.
• Salt substitutes or potassium-rich foods should be used with caution as colistimethate sodium can affect potassium levels in the body.
• Ensure adequate fluid intake to maintain hydration, especially if experiencing diarrhea as a side effect.
• Consult a healthcare professional for personalized advice regarding dietary restrictions or recommendations during the treatment period.
• No specific food interactions are known to directly impact the effectiveness of colistimethate sodium injection.

Store colistimethate sodium 80MG injection in a controlled room temperature environment, typically between 68°F and 77°F (20°C and 25°C), with occasional excursions permitted between 59°F and 86°F (15°C and 30°C). Keep the injection away from excessive heat, direct sunlight, and moisture, as these can degrade the medication. Always check the expiration date before use, and discard any expired or unused vials according to local regulations and guidelines. Proper disposal methods are crucial to prevent environmental contamination; do not flush or pour the medication down the drain. Consult your pharmacist or healthcare provider for specific instructions on safe disposal practices. Keep the medication securely stored, out of reach of children and pets, to prevent accidental exposure or ingestion.

Following are the quick tips for Colistimethate Sodium 80mg Injection:

• Administer the injection under medical supervision as directed by your doctor.
• Ensure the injection is prepared and administered by a trained healthcare professional.
• Inform your doctor if you have any allergies or kidney-related issues before receiving the injection.
• Do not reuse or share needles and syringes to prevent infections.
• Store the injection as directed on the packaging, typically at room temperature away from light.
• Dispose of any unused or expired medication properly, do not flush or throw it into the trash.
• In case of any severe side effects or allergic reactions, seek immediate medical attention.