Combantrin (50mg/ml) 30ml Suspension

Pyrantel pamoate is an anthelmintic medication that acts by interfering with the nervous system of parasitic worms, causing paralysis and death. Its primary mechanism of action involves binding to acetylcholine receptors in the worm's muscle cells, leading to a sustained depolarization of the cell membrane. This disruption in the normal nerve impulses prevents the worms from maintaining normal muscle function, resulting in their inability to move or maintain their position in the intestine. This paralysis allows the host's natural defenses to eliminate the weakened worms, which are then passed out of the body.

Anthelmintic

Suspension

The following are the uses of Pyrantel Pamoate 50mg Syrup/Suspension:

• Used for the treatment of intestinal infections caused by certain parasitic worms.
• Used for eliminating roundworms and hookworms in the intestines.
• Used for relieving symptoms such as abdominal pain, diarrhea, and nutritional deficiencies caused by these infections.
• Used for preventing the spread of worm infections to others.
• Used for maintaining good hygiene and health in communities with high infection rates.
• Used for deworming pets and livestock, ensuring a healthier environment.
• Used for travelers visiting regions with a high prevalence of parasitic worms as a preventive measure.

In the case of an overdose of Pyrantel Pamoate 50mg Syrup/Suspension, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and dizziness. It is important to promptly seek medical advice and inform healthcare professionals about the suspected overdose. They will provide guidance and may recommend appropriate treatment options, such as inducing vomiting or administering activated charcoal to prevent further absorption of the medication.

In the case of a missed dose of Pyrantel Pamoate 50mg Syrup/Suspension, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed, as they can advise you on the best course of action to ensure the treatment's effectiveness.

To administer Pyrantel Pamoate 50mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with a dosing cup or oral syringe, and take it orally, following the instructions provided by your healthcare professional regarding dosage and frequency.

Following are the conditions when Pyrantel Pamoate 50mg Syrup/Suspension should not be used:

• Must not be used in individuals with a known allergy to Pyrantel Pamoate or any of its ingredients.
• Not suitable for individuals with known hypersensitivity or previous severe reactions to similar medications.
• Contraindicated in patients with known liver impairment or disease.
• Should not be used if the patient is taking other medications that may interact adversely with Pyrantel Pamoate.
• Avoid using in patients with a history of seizures or epilepsy.
• Not recommended for individuals with a compromised immune system or those who are immunocompromised.
• Do not administer if the patient is unable to swallow or has a gastrointestinal obstruction.

The side effects of Pyrantel Pamoate 50mg Syrup/Suspension may include:

• Abdominal pain
• Nausea and vomiting
• Diarrhea
• Dizziness
• Headache
• Itching or skin rash
• Temporary worsening of worm-related symptoms
• Fatigue

Following are the precautions and warnings for Pyrantel Pamoate 50mg Syrup/Suspension:

• Do not exceed the recommended dosage, as an overdose can lead to severe adverse effects.
• This medication should be used with caution in patients with known liver or kidney disease, as it may require dosage adjustments.
• Patients with a history of seizures or epilepsy should be closely monitored while taking this medication.
• Pyrantel Pamoate may cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• It is important to complete the full course of treatment to ensure effective elimination of the parasite.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the medication's effects during these periods are not well-established.
• Keep this medication out of the reach of children and pets to prevent accidental ingestion.
• Store the medication as directed on the package to maintain its effectiveness and stability.

Following are the drug interactions for Pyrantel Pamoate 50mg Syrup/Suspension:

• When combined with other antiparasitic medications like albendazole or ivermectin, close monitoring for potential additive side effects is necessary.
• Pyrantel Pamoate may decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Antacids containing aluminum or magnesium can reduce the absorption of Pyrantel Pamoate, so they should be taken at separate times.
• The absorption of Pyrantel Pamoate may be affected by cholestyramine, leading to reduced effectiveness.
• Using Pyrantel Pamoate with other drugs that cause neuromuscular blockade, such as tubocurarine, can enhance muscle relaxation and potentially increase the risk of respiratory depression.
• Caution is advised when combining with medications that affect the central nervous system, as it may enhance their effects.
• Prolonged use of Pyrantel Pamoate may increase the risk of drug interactions with long-term medications, requiring periodic reassessment.

Following are the food interactions for Pyrantel Pamoate 50mg Syrup/Suspension:

• Avoid consuming grapefruit or grapefruit juice as it may decrease the drug's absorption, leading to reduced effectiveness.
• Alcohol consumption should be limited or avoided as it can cause increased side effects such as dizziness, drowsiness, and stomach discomfort.
• Fatty foods can delay the absorption of Pyrantel Pamoate, so it is best to take the medication on an empty stomach.
• Dairy products like milk and yogurt may interfere with the absorption of the medication, so it is recommended to wait a few hours after taking the medication before consuming dairy.
• Avoid caffeine as it may increase the drug's side effects, particularly nervousness and insomnia.
• Spicy foods may irritate the stomach, especially if you are experiencing gastrointestinal side effects, so it is advisable to opt for milder options.
• Certain high-fiber foods like raw vegetables and whole grains may reduce the absorption of the medication, so consider taking the medication at least an hour before or a few hours after consuming such foods.
• Always ensure you follow the dosage instructions provided by your healthcare professional, and inform them about any dietary concerns or restrictions you may have.

Pyrantel Pamoate 50mg Syrup/Suspension should be stored in a cool and dry environment, ideally at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication securely sealed within its original packaging to maintain its integrity. Avoid storage in bathrooms or near heat-emitting appliances like stoves or heaters, as these conditions can compromise the medicine's effectiveness. Prior to administration, inspect the packaging for any expiration dates, and responsibly dispose of any unused or expired syrup; refrain from discarding it via toilets or drains. Consult your pharmacist or healthcare professional for appropriate disposal practices. Additionally, exercise caution to store the medication beyond the reach of children to prevent accidental consumption.

Following are the quick tips for Pyrantel Pamoate 50mg Syrup/Suspension:

• Administer the correct dose as prescribed by your veterinarian for your pet's weight.
• Shake the bottle thoroughly before each use to ensure proper medication distribution.
• Use the provided measuring device for accurate dosing, and do not estimate.
• Give the syrup directly into your pet's mouth or mix it with a small amount of food they enjoy.
• If your pet spits out the medication, consult your veterinarian for alternative administration methods.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Dispose of any unused or expired medication safely, following local guidelines.