COMBANTRIN 250MG TAB

Pyrantel Pamoate, the active ingredient in the 250MG tablet, acts as an anthelmintic agent primarily through its effect on the nervous system of parasitic worms. It binds to acetylcholine receptors on the worm's muscle cells, causing sustained muscle contractions and paralysis. This mechanism disrupts the worm's ability to maintain its position in the intestinal tract, leading to detachment and subsequent elimination from the host's body. The drug's mode of action selectively targets the parasite's nervous system, ensuring its effectiveness against various intestinal nematodes while minimizing impact on the host's physiology.

Anthelmintic.

Tablet

The following are the uses of Pyrantel Pamoate 250MG Tablet:

• Used for treating intestinal infections caused by certain parasites.
• Used to eliminate roundworms and hookworms in the intestines.
• Used for controlling and preventing parasitic infestations in pets and animals.
• Used for managing Ascariasis and Enterobiasis (pinworm infection).
• Used to improve nutritional absorption by removing parasites.
• Used for relieving abdominal pain and discomfort caused by parasitic infections.
• Used to support overall health and well-being by reducing parasitic load.

In the case of an overdose of Pyrantel Pamoate 250MG Tablets, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and dizziness. It is important to seek medical advice promptly if you suspect an overdose. Treatment may involve supportive care, including monitoring vital signs and managing symptoms. Prompt action can help mitigate potential adverse effects, and healthcare professionals should be consulted for appropriate guidance and management strategies in the event of an overdose.

In the case of a missed dose of Pyrantel Pamoate 250MG Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or provide specific instructions to ensure the treatment remains effective. It is important to adhere to the prescribed dosage to maximize the benefits of the medication.

To take Pyrantel Pamoate 250MG Tablet, swallow the tablet whole with a full glass of water, preferably on an empty stomach, exactly as directed by your healthcare provider, usually 3 times a day (every 8 hours) for 3 days.

Following are the conditions when Pyrantel Pamoate 250MG Tablet should not be used:

• Do not take if you have a known allergy to Pyrantel Pamoate or any of its ingredients.
• Avoid using if you have a known history of hypersensitivity reactions to similar medications.
• Do not administer to infants under 2 months of age.
• Should not be used if you have known intestinal blockage or obstruction.
• Contraindicated in individuals with known liver or kidney disease.
• Do not use if you have uncontrolled nausea, vomiting, or difficulty swallowing.
• Not recommended for those with a history of seizures or epilepsy.

The side effects of Pyrantel Pamoate 250MG Tablet may include:

• Nausea and vomiting
• Dizziness or lightheadedness
• Diarrhea
• Abdominal pain or cramps
• Headache
• Itching or rash
• Drowsiness or fatigue
• Increased heart rate

Following are the precautions and warnings for Pyrantel Pamoate 250MG Tablet:

• Avoid using Pyrantel Pamoate if you have a known allergy to any of its ingredients, and seek immediate medical attention if you experience any allergic reactions.
• Consult your doctor if you have a history of liver disease, as they may need to monitor your liver function during treatment.
• This medication should be used with caution in individuals with a history of seizures or epilepsy, as it may potentially lower the seizure threshold.
• Pyrantel Pamoate should be used with care in elderly patients, as they may be more sensitive to its side effects.
• Do not exceed the recommended dosage, and follow the prescribed treatment duration to avoid potential toxicity.
• Inform your doctor if you are pregnant or breastfeeding, as they will assess the potential benefits and risks before prescribing this medication.
• Keep this medication out of reach of children and pets, and store it in a safe place at room temperature.

Following are the drug interactions for Pyrantel Pamoate 250MG Tablet:

• Pyrantel Pamoate can interact with piperazine, an anthelmintic drug, potentially reducing the efficacy of both medications.
• May decrease the absorption of oral contraceptives, requiring additional contraceptive measures during treatment.
• Concomitant use with other anthelmintics like albendazole or mebendazole can increase the risk of adverse effects and should be avoided.
• Theophylline levels may be affected, requiring monitoring and dose adjustments if used together.
• Pyrantel Pamoate can interact with antacids, potentially reducing its effectiveness, so separate administration by at least 2 hours.
• May increase the risk of bleeding when taken with anticoagulants or antiplatelet drugs, warranting close monitoring.
• Certain antibiotics, such as metronidazole, may have reduced absorption when taken with Pyrantel Pamoate, impacting their effectiveness.

Following are the food interactions for Pyrantel Pamoate 250MG Tablet:

• Avoid consuming grapefruit and grapefruit juice, as they can decrease the drug's effectiveness by altering the absorption and metabolism of Pyrantel Pamoate.
• Alcohol consumption should be limited as it may increase the risk of side effects and liver-related issues, especially when used for extended periods.
• Dairy products like milk, cheese, and yogurt can interfere with the absorption of Pyrantel Pamoate, so it's best to separate them by a few hours.
• High-fat meals can slow down the absorption of the medication, potentially reducing its effectiveness.
• Avoid consuming caffeine-rich foods and beverages, as they may increase the stimulatory side effects of the medication.
• Certain vegetables like broccoli, Brussels sprouts, and cabbage contain compounds that can affect the metabolism of Pyrantel Pamoate, and should be consumed in moderation.
• Herbal supplements, particularly St. John's Wort, may reduce the effectiveness of Pyrantel Pamoate by influencing drug metabolism.
• Always ensure you take the medication with a full glass of water to aid in proper absorption and reduce the risk of esophageal irritation.

Pyrantel Pamoate 250MG Tablets should be stored in a cool and dry place, preferably at room temperature (around 20-25°C) in their original container. It is crucial to keep the tablets away from excessive heat, moisture, or direct sunlight as these conditions can degrade the medication. Always check the expiration date before using the tablets, and if they have expired, do not use them and dispose of them carefully. For proper disposal, do not throw the tablets into the garbage or flush them down the toilet; instead, consult your pharmacist or local waste management authority for guidance on how to safely dispose of pharmaceutical waste. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Pyrantel Pamoate 250MG Tablet:

• Take the tablet as directed by your doctor; follow the prescription carefully.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Take the tablet on an empty stomach, preferably 1 hour before or 2 hours after meals.
• Avoid consuming alcohol or grapefruit juice as it may affect the medication's effectiveness.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Do not share your medication with others, even if they have similar symptoms.