Contine (10mg) 56 Tablets

Memantine 10mg Tablet primarily acts as an N-methyl-D-aspartate (NMDA) receptor antagonist. It exerts its effects by binding to and modulating the NMDA receptors, which are crucial for synaptic plasticity and neuronal communication. Specifically, memantine blocks the excessive activation of NMDA receptors by glutamate, a neurotransmitter. This blockade is use-dependent, meaning it occurs more prominently when there is excessive or prolonged activation of these receptors. By selectively blocking the NMDA receptors, memantine helps regulate the influx of calcium ions into neurons, thereby modulating neuronal excitability and reducing excitotoxicity. This mechanism is thought to contribute to the therapeutic effects observed in conditions associated with glutamatergic dysfunction, such as Alzheimer's disease, where memantine can help improve cognitive function and slow down disease progression.

NMDA receptor antagonist.

Tablet

The following are the uses of Memantine 10mg Tablet:

• Used for treating moderate to severe dementia related to Alzheimer's disease.
• Used to improve memory, awareness, and the ability to perform daily functions.
• Used to regulate glutamate, an essential brain chemical for learning and memory.
• Used to delay the worsening of Alzheimer's symptoms.
• Used for patients with vascular dementia, improving cognitive function.
• Used to enhance overall cognitive performance and slow cognitive decline.
• Used to potentially stabilize or slightly improve mental function in some individuals.

To be taken as per doctor's prescription

In the case of an overdose of Memantine 10mg Tablets, it is important to act swiftly. Symptoms may include dizziness, confusion, agitation, and in severe cases, seizures or loss of consciousness. If you or someone you know has taken an excessive amount, contact a healthcare professional or a poison control center immediately. They will provide guidance on the necessary steps to take, which may include seeking medical attention and receiving supportive care to manage the symptoms until the drug is cleared from the body. Prompt action is essential to ensure the best possible outcome.

In the case of a missed dose of Memantine 10mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosing schedule and ensure the best treatment outcome. It is generally recommended to set a daily routine or use reminder tools to help you remember to take your medication on time.

To take Memantine 10mg Tablet, place the tablet in your mouth and swallow it whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically starting with a lower dose and gradually increasing over time.

Following are the conditions/situations when Memantine 10mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Memantine or any of its ingredients.
• Not suitable for patients with severe kidney disease or kidney failure.
• Contraindicated in patients with severe liver disease or liver failure.
• Should not be used to treat dementia caused by conditions other than Alzheimer's disease.
• Not recommended for individuals with epilepsy or a history of seizures.
• Avoid use in patients with urinary tract infections or obstruction.
• Do not administer if the patient has recently suffered a heart attack.
• Contraindicated in individuals with severe respiratory conditions or respiratory failure.

The side effects of Memantine 10mg Tablet may include:

• Dizziness
• Headache
• Confusion
• Constipation
• Nausea and vomiting
• Loss of appetite
• Increased agitation or aggression
• Hallucinations

Following are the precautions and warnings for Memantine 10mg Tablet:

• Not recommended for individuals with severe kidney impairment • dosage adjustments are necessary for patients with moderate kidney impairment.
• Patients with a history of seizures or those at risk of seizures should be closely monitored, as Memantine may increase the risk of seizures.
• Not suitable for individuals with severe liver impairment, and caution should be exercised in patients with mild to moderate liver impairment.
• Not recommended for patients with a known hypersensitivity or allergy to Memantine or any of its excipients.
• Patients with urinary tract infections or those at risk of infections should be monitored, as Memantine may cause urinary retention or difficulty in urination.
• Caution is advised when discontinuing Memantine, as sudden withdrawal may lead to symptoms such as headache, dizziness, and insomnia.
• May cause dizziness or drowsiness; patients experiencing these symptoms should avoid driving or operating heavy machinery.
• The safety and effectiveness of Memantine in pediatric patients have not been established, and it is not recommended for use in children.

Following are the drug interactions for Memantine 10mg Tablet:

• Memantine may interact with other NMDA receptor antagonists like amantadine, ketamine, or dextromethorphan, potentially leading to increased side effects and toxicity.
• Concomitant use with anticholinergic drugs can increase the risk of confusion, constipation, and urinary retention.
• Antiepileptic medications, such as phenytoin or carbamazepine, may decrease the effectiveness of Memantine.
• Memantine can affect the absorption of some antibiotics, such as tetracyclines, reducing their efficacy.
• It may increase the blood levels of certain medications like quinidine, potentially requiring dosage adjustments.
• Caution is advised when combining Memantine with drugs that lower the seizure threshold, as it may increase the risk of seizures.
• Memantine may interfere with the action of dopaminergic drugs used in Parkinson's disease, requiring careful monitoring.

Following are the food interactions for Memantine 10mg Tablet:

• Avoid alcohol consumption while taking this medication as it may impair your thinking or reactions and increase the risk of side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Memantine, potentially leading to increased drug levels in the body.
• Caffeine intake should be monitored as it can enhance the stimulating effects of Memantine, possibly causing anxiety or agitation.
• Avoid tyramine-rich foods like aged cheeses, cured meats, and certain types of beer, as Memantine may interact with tyramine, leading to increased blood pressure.
• Avoid excessive consumption of foods high in tyramine while taking Memantine to prevent potential blood pressure spikes.
• Herbal teas containing St. John's Wort should be avoided as it may reduce the effectiveness of Memantine by influencing its metabolism.
• Avoid large meals high in fat and calories as they may affect the absorption of Memantine, potentially altering its effectiveness.
• Always follow dietary advice provided by your healthcare professional, especially if you have any specific dietary restrictions or medical conditions.

Memantine 10mg Tablets should be stored in a cool, dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Protect the tablets from light and moisture by keeping them in their original container, tightly sealed. It's crucial to avoid exposure to excessive heat or cold, so steer clear of storing them in the bathroom or freezer. Regularly check the expiration date, and do not use the medication if it is expired. For disposal, do not throw the medication in the trash or flush it down the toilet. The best practice is to consult your pharmacist or local waste disposal company for guidance on safe and environmentally friendly disposal methods, ensuring that the medication is properly discarded without causing harm to others or the environment. Keep this medication out of children's reach to prevent accidental consumption.

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Following are the quick tips for Memantine 10mg Tablet:

• Take the tablet as directed by your doctor, typically twice a day.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Maintain a consistent daily routine for taking the medication.
• Avoid missing doses; if you miss a dose, take it as soon as you remember, unless it's close to the next dose.
• Do not double the dose to make up for a missed one.
• Inform your doctor if you have any kidney issues, as dosage adjustments may be necessary.
• Store the medication at room temperature, away from moisture and light.