Corbis-H (10mg) 20 Tablets

Hydrochlorothiazide and bisoprolol work synergistically in the bisoprolol 10mg tablet. Hydrochlorothiazide, a thiazide diuretic, inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidneys, leading to increased excretion of water and electrolytes, which helps lower blood pressure. It also promotes vasodilation by reducing blood volume and peripheral vascular resistance. Bisoprolol, a beta-blocker, blocks beta-1 adrenergic receptors in the heart, resulting in decreased heart rate, cardiac output, and blood pressure. By slowing the heart rate and reducing the force of contraction, bisoprolol lowers blood pressure and decreases the workload on the heart. Together, these mechanisms contribute to the antihypertensive effect of the bisoprolol 10mg tablet, helping to control high blood pressure and reduce cardiovascular risks.

Hydrochlorothiazide, bisoprolol 10mg

Thiazide diuretic, beta-blocker

Tablet

The following are the uses of Hydrochlorothiazide, bisoprolol 10mg Tablet:

• Used for treating high blood pressure, helping to lower and control it.
• Used to reduce the risk of heart-related issues, such as heart attacks or strokes, by managing blood pressure.
• Used for fluid retention (edema) relief, particularly in conditions like heart failure.
• Used to enhance the heart's efficiency and reduce its workload.
• Used to manage and prevent potential complications from conditions like diabetes or kidney disease.
• Used for reducing the symptoms of mild to moderate heart failure.
• Used to improve overall cardiovascular health and well-being.

In the case of an overdose of Hydrochlorothiazide and bisoprolol 10mg tablets, symptoms may include dizziness, lightheadedness, and fainting due to a sudden drop in blood pressure. Additionally, an overdose can lead to an irregular heartbeat and potential heart complications. Immediate medical intervention is necessary, and healthcare professionals should be contacted to provide appropriate treatment and support to manage the symptoms and prevent further health risks associated with the overdose.

In the case of a missed dose of Hydrochlorothiazide, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. If it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. For bisoprolol 10mg tablets, if you miss a dose, take it as soon as you remember, but if it's near the time for your next dose, skip the missed dose and continue with your regular dosing regimen. Do not double the dose to make up for a missed one.

To take the Hydrochlorothiazide, bisoprolol 10mg Tablet, swallow the tablet whole with a full glass of water once daily, preferably at the same time each day, as directed by your healthcare provider.

Hydrochlorothiazide and bisoprolol 10mg Tablet should not be used in the following conditions:

• Avoid if you have a known allergy to hydrochlorothiazide, bisoprolol, or other sulfonamide-derived medications.
• Do not use if you have severe kidney disease or if you are unable to urinate.
• Contraindicated in patients with severe liver disease or impaired liver function.
• Should not be taken if you have severe bronchospastic disease or severe asthma.
• Avoid if you have a history of slow heart rate (bradycardia) or heart block.
• Not recommended for individuals with metabolic acidosis or severe electrolyte imbalances.
• Do not use if you are experiencing diabetic ketoacidosis.
• Contraindicated during severe hypotension (low blood pressure) or shock.

The side effects of Hydrochlorothiazide, bisoprolol 10mg Tablet may include:

• Fatigue and weakness
• Dizziness or lightheadedness
• Headache
• Nausea and vomiting
• Diarrhea or constipation
• Dry mouth
• Skin rash or itching
• Changes in blood sugar levels

Following are the precautions and warnings for Hydrochlorothiazide, bisoprolol 10mg Tablet:

• Individuals with a known allergy to hydrochlorothiazide or bisoprolol should not take this medication.
• Patients with kidney or liver disease should exercise caution, as dosage adjustments may be necessary under medical supervision.
• It may cause dizziness or lightheadedness, so activities requiring alertness should be avoided until the medication's effects are known.
• Alcohol consumption should be avoided as it may increase the risk of side effects.
• Patients with diabetes should monitor their blood sugar levels regularly as this medication can affect glucose control.
• Not recommended for use during pregnancy or breastfeeding without medical advice.
• Elderly patients may be more sensitive to the effects of this medication, requiring careful monitoring.

Following are the drug interactions for Hydrochlorothiazide, bisoprolol 10mg Tablet:

• Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the antihypertensive effects of bisoprolol and increase the risk of renal dysfunction.
• Bisoprolol may enhance the effects of other antihypertensive agents, leading to hypotension.
• Hydrochlorothiazide can increase the risk of lithium toxicity by reducing its renal clearance.
• The hypokalemic effect of hydrochlorothiazide may be enhanced by concomitant use with other potassium-depleting drugs.
• Drugs affecting renal function can alter the elimination of hydrochlorothiazide, potentially requiring dosage adjustments.
• The antihypertensive effect of bisoprolol may be reduced by nonsteroidal anti-inflammatory drugs (NSAIDs).
• Caution is advised when using bisoprolol with Class I antiarrhythmic drugs, as it may enhance the cardiac depressant effects.
• The hypokalemic effect of hydrochlorothiazide can increase the risk of digoxin toxicity.

Following are the food interactions for Hydrochlorothiazide, bisoprolol 10mg Tablet:

• Avoid excessive salt intake as it can reduce the blood pressure-lowering effect of bisoprolol. High-sodium foods like processed snacks, canned soups, and salty condiments should be limited.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of bisoprolol, potentially leading to increased drug levels in the body and a higher risk of side effects.
• Alcohol can lower blood pressure further and may enhance the sedative effects of bisoprolol, causing dizziness and drowsiness. It's advisable to limit alcohol consumption or avoid it if possible.
• Foods rich in potassium, such as bananas, oranges, and spinach, should be consumed moderately as Hydrochlorothiazide can cause potassium loss. Monitoring potassium levels and adjusting dietary intake may be necessary.
• Hydrochlorothiazide may increase blood sugar levels, so patients with diabetes should monitor their glucose levels and adjust their diet accordingly, focusing on low-sugar and complex carbohydrate foods.
• Dairy products like milk and yogurt can interfere with the absorption of bisoprolol, so it is recommended to take the medication with water and avoid consuming these products around the time of medication intake.
• Caffeine intake should be monitored as it can increase blood pressure and heart rate, working against the effects of bisoprolol. Limit coffee, tea, and energy drinks, especially if you have a history of high blood pressure.
• A balanced diet low in saturated fats and cholesterol is advisable, as Hydrochlorothiazide may affect lipid metabolism. Focus on lean proteins, whole grains, and a variety of fruits and vegetables.

Hydrochlorothiazide, bisoprolol 10mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, and moisture. The medication bottle should be kept tightly sealed to maintain its integrity and prevent contamination. It is crucial to adhere to the recommended storage conditions to ensure the drug's effectiveness and safety. When disposing of unused or expired tablets, do not flush them down the toilet or discard them into the drainage system. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to minimize environmental impact. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Hydrochlorothiazide, bisoprolol 10mg Tablet:

• Consult your doctor for the right dosage and duration based on your medical condition.
• Take the tablet as directed, typically once daily or as advised.
• Consume the tablet with a glass of water, preferably at the same time each day.
• Avoid crushing or chewing the tablet; swallow it whole for optimal absorption.
• Maintain a consistent medication schedule to ensure effectiveness.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets at room temperature, away from moisture and sunlight.