CORDARONE INJ 150MG/3ML

Amiodarone 150MG Injection primarily works by prolonging the duration of the heart's electrical cycle, particularly the action potential. It blocks certain ion channels in cardiac muscle cells, including potassium and calcium channels, which slows down the rate at which the heart muscle cells repolarize. This action helps to stabilize the heart rhythm by prolonging the cardiac action potential, thereby reducing the risk of abnormal electrical activity that can lead to arrhythmias. Additionally, amiodarone has some beta-adrenergic blocking effects, which contribute to its anti-arrhythmic properties by reducing the heart's responsiveness to certain stress hormones.

Amiodarone 150MG

Antiarrhythmic

Injection

The following are the uses of Amiodarone 150MG Injection:

• Used for restoring normal heart rhythms in life-threatening arrhythmias.
• Used to treat and prevent irregular, fast heartbeats.
• Used for maintaining a steady, strong heartbeat during and after surgery.
• Used for managing ventricular fibrillation, a critical condition requiring immediate treatment.
• Used as an effective option for treating atrial fibrillation when other medications are not suitable.
• Used for long-term management of recurrent arrhythmias, improving heart function.
• Used to stabilize heart rate in emergency situations, allowing for further treatment.

In the case of an overdose of Amiodarone 150MG Injection, symptoms may include severe bradycardia, cardiac arrest, severe hypotension, and heart block. It is important to seek medical assistance immediately if an overdose is suspected. Treatment involves close monitoring of vital signs, cardiac rhythm, and blood pressure. Medical professionals may administer specific antidotes and provide supportive care to manage the adverse effects and stabilize the patient's condition.

In the case of a missed dose of Amiodarone 150MG Injection, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication and adjust your dosing schedule.

To administer Amiodarone 150MG Injection, prepare the intravenous solution by mixing the contents with a compatible diluent as directed by a healthcare professional, and infuse the solution slowly through a secure intravenous line under medical supervision.

Here are the situations when Amiodarone 150MG Injection should not be used:

• Should not be used in patients with a known allergy or hypersensitivity to Amiodarone or any of its components.
• Contraindicated in patients with a certain type of heart rhythm disorder called 'atrial fibrillation' that is not related to a medical condition called Wolff-Parkinson-White syndrome.
• Not recommended for individuals with a slow heart rate (bradycardia) unless a pacemaker is present.
• Should not be used in patients with a type of heart block (second or third-degree AV block) without a pacemaker.
• Contraindicated in patients with a recent heart attack (acute myocardial infarction) who have unstable vital signs.
• Not suitable for individuals with severely reduced liver function.
• Should be avoided in patients with a specific type of lung disorder called 'alveolar-interstitial pneumonitis' or a history of this condition.
• Not recommended for individuals with a particular type of irregular heart rhythm called 'ventricular tachycardia' that requires immediate treatment.

The side effects of Amiodarone 150MG Injection may include:

• Skin sensitivity to sunlight, resulting in rashes or sunburn
• Nausea and vomiting
• Loss of appetite and weight loss
• Fatigue and general weakness
• Unstable or irregular heartbeat (arrhythmia)
• Blurred vision or visual disturbances
• Shortness of breath and coughing
• Neuropathy, characterized by tingling or numbness in the hands and feet.

Following are the precautions and warnings for Amiodarone 150MG Injection:

• Amiodarone should be used with extreme caution in patients with known heart conditions, especially those with severe heart disease, as it may affect heart rhythm.
• Regular monitoring of liver function is necessary during treatment, as Amiodarone can cause liver-related side effects.
• Patients with thyroid disorders should be closely monitored, as this medication can affect thyroid function.
• Avoid sudden discontinuation of the medication; dosage should be gradually reduced to prevent worsening of heart conditions.
• May cause vision changes, including halos and light sensitivity; patients should be cautious when driving or operating machinery.
• Not recommended for use during pregnancy and breastfeeding unless the potential benefits outweigh the risks.
• Elderly patients may be more susceptible to side effects, and dosage adjustments might be required.
• Inform your doctor about all other medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Amiodarone 150MG Injection:

• Amiodarone may prolong the effects of certain beta-blockers, calcium channel blockers, and other antiarrhythmic drugs, leading to increased risk of bradycardia and hypotension.
• The combination with digoxin can increase serum digoxin levels, requiring close monitoring.
• It may reduce the metabolism of warfarin, increasing the risk of bleeding. Regular monitoring of INR is necessary.
• Using with phenytoin or carbamazepine may result in decreased efficacy of Amiodarone.
• The effects of simvastatin and other statins can be increased, raising the risk of myopathy and rhabdomyolysis.
• Rifampin can decrease Amiodarone levels, potentially reducing its effectiveness.
• Combining with flecainide or sotalol may increase the risk of ventricular arrhythmias.
• Amiodarone may increase plasma levels of cyclosporine, requiring dosage adjustments.

Following are the food interactions for Amiodarone 150MG Injection:

• Grapefruit and grapefruit juice consumption should be avoided as they can significantly increase the blood levels of Amiodarone, leading to potential toxicity.
• Alcohol intake should be minimized or avoided as it can enhance the sedative effects of Amiodarone, increasing the risk of dizziness and fainting.
• High-fat meals may delay the absorption of Amiodarone, affecting its effectiveness. It is advisable to take the medication on an empty stomach or with a light meal.
• Caffeine-rich beverages like coffee and energy drinks might interact with Amiodarone, causing irregular heart rhythms. It's best to limit caffeine consumption.
• Avoid excessive consumption of salt and salty foods as Amiodarone can lead to sodium retention, potentially worsening heart conditions.
• Amiodarone can lower blood sugar levels, so monitoring sugar intake is crucial, especially for diabetics. Avoid excessive sugary foods and drinks.
• Consuming foods rich in vitamin K, such as leafy greens, can interfere with the anticoagulant effect of Amiodarone, affecting blood clotting.
• Always consult your healthcare provider for specific dietary guidelines while using Amiodarone to ensure the medication's optimal efficacy and safety.

Amiodarone 150MG Injection should be stored in a controlled environment, specifically at room temperature between 20-25°C (68-77°F), in a cool and dry place. Protect the injection from direct sunlight, heat, and moisture to maintain its integrity. Keep the medication in its original packaging, ensuring the container is tightly sealed to prevent contamination. It is crucial to dispose of any unused or expired amiodarone properly; do not dispose of it via wastewater or household waste. Contact a healthcare professional or pharmacist for guidance on safe disposal methods to minimize environmental impact. Always keep medications out of the sight and reach of children to prevent accidental ingestion.

Following are the quick tips for Amiodarone 150MG Injection:

• Administer the injection under medical supervision for the best therapeutic outcome.
• Ensure proper dosage calculation based on body weight and medical condition.
• Amiodarone injection should be administered slowly, typically over a period of several minutes.
• Monitor vital signs during and after the injection to ensure patient stability.
• Avoid rapid infusion to prevent adverse effects like hypotension.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Dispose of any unused or expired medication properly, as per local guidelines.