Cordion (250mg) 5ml, 10 Ampoule Injections

Cordion (250mg) 5ml, 10 Ampoule Injections

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  • Manufacturer SIZA International (Private) Limited
  • Generic Name

    Cyproheptadine

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Cyproheptadine's primary mechanism of action is as an antagonist of histamine H1 receptors, effectively blocking the effects of histamine. This antihistamine action helps to reduce symptoms associated with allergic reactions. Moreover, Cyproheptadine also acts as an antagonist at serotonin (5-HT2) receptors, which contributes to its ability to suppress serotonin-induced reactions and alleviate symptoms related to serotonin activity in the body. By blocking these specific receptors, Cyproheptadine can effectively manage various allergic and serotonin-related conditions.

  • Ingredients

    Cyproheptadine

  • Drug Class

    Antihistamine

  • Dosage Form

    Injection

  • Uses

    The following are the uses of Cyproheptadine injection:

    • Used for treating severe allergic reactions and anaphylaxis to provide rapid relief.
    • Used for managing allergic symptoms like hives, itching, and skin reactions.
    • Used for short-term control of severe allergic rhinitis and allergic conjunctivitis.
    • Used for suppressing allergic responses and reducing inflammation.
    • Used for preventing and treating migraine headaches.
    • Used for appetite stimulation in certain conditions where weight gain is essential.
    • Used for providing quick relief during severe allergic episodes.
  • In case of Overdose

    In the case of an overdose of Cyproheptadine injection, the severity of symptoms can vary. Nausea, vomiting, and drowsiness may occur, and in more severe cases, respiratory depression, hypotension, and seizures are possible. Prompt medical attention is necessary, as treatment may involve supportive care, including monitoring vital signs and managing symptoms. It is crucial to seek emergency medical assistance and provide healthcare professionals with information about the suspected overdose.

  • Missed Dose

    In the case of a missed dose of Cyproheptadine injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, it is best to skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to safely adjust your medication regimen.

  • How To Use

    To administer the Cyproheptadine injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the prescribed dosage intramuscularly or subcutaneously, ensuring the entire dose is delivered, and then gently withdraw the needle and apply light pressure with a sterile gauze pad if needed.

  • When Not to Use

    Following are the conditions/situations when Cyproheptadine injection should be avoided:

    • Must not be used in patients with a known allergy or hypersensitivity to Cyproheptadine or any of its components.
    • Contraindicated in patients with narrow-angle glaucoma.
    • Not suitable for individuals with a history of gastrointestinal obstruction or urinary retention.
    • Should be avoided in patients with severe high blood pressure (hypertension) or cardiovascular disease.
    • Contraindicated during breastfeeding as it may pass into breast milk and harm the infant.
    • Not recommended for children below 2 years of age due to potential serious side effects.
    • Should not be used in patients with severe central nervous system (CNS) depression or coma.
    • Avoid in patients with a history of seizures or epilepsy.
    • Contraindicated in patients with severe liver or kidney impairment.
    • Must not be used in patients with a history of pyloric stenosis or prostatic hypertrophy.
  • Side Effects

    The side effects of Cyproheptadine injection may include:

    • Drowsiness or sedation
    • Dry mouth and throat
    • Blurred vision or temporary vision changes
    • Constipation
    • Increased appetite and weight gain
    • Nausea and vomiting
    • Dizziness or lightheadedness
    • Confusion or disorientation
  • Precautions & Warnings

    Following are the precautions and warnings:

    • Cyproheptadine injection should be used with caution in patients with a history of hypersensitivity reactions, as it may cause allergic reactions including skin rash, itching, and anaphylaxis.
    • It is important to monitor blood pressure during treatment, as Cyproheptadine can cause a significant drop in blood pressure, especially in patients with hypertension.
    • This medication can impair mental alertness and coordination, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
    • Cyproheptadine should be used with caution in elderly patients as they may be more sensitive to its side effects, particularly drowsiness and dizziness.
    • Patients with a history of gastrointestinal problems such as ulcers or obstruction should use this medication with caution, as it can affect gastrointestinal motility.
    • It may cause urinary retention, so patients with existing urinary problems should be monitored closely during treatment.
    • Cyproheptadine injection should be used with care in individuals with narrow-angle glaucoma, as it can worsen the condition.
  • Drug Interactions

    Following are the drug interactions for Cyproheptadine injection:

    • Antidepressants like MAOIs (Monoamine Oxidase Inhibitors) and SSRIs can interact, potentially leading to serotonin syndrome.
    • Cyproheptadine may increase the effects of CNS depressants such as alcohol, opioids, or benzodiazepines.
    • The effectiveness of Antihistamines and Anticholinergics can be altered when used concurrently.
    • It may reduce the effectiveness of antipsychotic medications.
    • Anticonvulsants' blood levels can be affected, requiring monitoring and dose adjustments.
    • Antihypertensive medications' effects might be counteracted by Cyproheptadine.
    • Caution is advised when combining with medications that affect liver function, as it may impact Cyproheptadine's metabolism.
  • Food Interactions

    Following are the food interactions to consider with Cyproheptadine injection:

    • Alcohol consumption should be avoided as it can increase the sedative effects of Cyproheptadine, leading to enhanced drowsiness and dizziness.
    • Grapefruit and its juice should be consumed with caution as they may interfere with Cyproheptadine's metabolism, potentially increasing its blood levels and side effects.
    • Avoid high-fat meals as they can delay the absorption and reduce the effectiveness of Cyproheptadine.
    • Caffeine intake should be monitored as Cyproheptadine may enhance its effects, causing increased nervousness and rapid heartbeat.
    • Avoid eating large quantities of chocolate, as Cyproheptadine may increase its effects, including potential mood changes and heart rhythm issues.
    • Be cautious with herbs like St. John's Wort, as it can decrease Cyproheptadine's effectiveness by increasing its metabolism.
    • Always follow healthcare provider's instructions regarding food interactions, especially when taking Cyproheptadine for specific conditions.
    • Certain foods may affect individual responses to Cyproheptadine, so observe any unusual reactions and consult a healthcare professional if needed.
  • Storage/Disposal

    Cyproheptadine injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), with brief excursions permitted between 59°F and 86°F (15°C and 30°C). Protect it from light and excessive heat, and avoid freezing. Keep the injection in its original packaging until use to maintain sterility. Dispose of any unused or expired medication responsibly; do not flush or pour it down the drain. Contact your pharmacist or healthcare provider for guidance on proper disposal methods to minimize environmental impact. Ensure the medication is stored securely, out of the reach of children and pets.

  • Quick Tips, if any

    Here are the quick tips for Cyproheptadine injection:

    • Ensure the injection is administered by a trained healthcare professional.
    • Inform your doctor about all medications you are taking.
    • Cyproheptadine may cause drowsiness; avoid driving or operating machinery until you know how it affects you.
    • Avoid alcohol consumption while using this medication.
    • If you experience persistent or severe side effects, contact your doctor promptly.
    • Do not stop using the medication without consulting your healthcare provider.
    • Store the injection as directed on the package to maintain its effectiveness.

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