Cosmin (0.05%) 10g Gel

Isotretinoin gel works by targeting and reducing the size of sebaceous glands in the skin, which are responsible for producing sebum. It binds to specific nuclear receptors known as retinoic acid receptors (RARs) within the sebaceous gland cells. This binding triggers a series of cellular events that lead to the inhibition of cellular proliferation and differentiation, ultimately resulting in the reduction of sebum production. Isotretinoin also exerts anti-inflammatory effects by modulating the expression of inflammatory mediators and reducing the presence of acne-causing bacteria on the skin. The overall mechanism of action contributes to the improvement of acne symptoms by normalizing the skin's microenvironment and reducing the factors that contribute to acne development.

Isotretinoin

Retinoid.

Gel

The following are the uses of Isotretinoin Gel:

• Used for treating severe acne that is resistant to other treatments.
• Used for reducing the appearance of acne scars and promoting skin healing.
• Used for controlling excess oil production in the skin.
• Used for preventing the development of new acne lesions.
• Used for improving skin texture and reducing skin inflammation.
• Used for managing acne in adults and adolescents.
• Used for long-term acne management, often in combination with other therapies.
• Used for achieving clearer skin and boosting self-confidence.

To be taken as per doctor's prescription

In the case of an overdose of Isotretinoin Gel, it is important to remain calm and take appropriate action. Seek medical advice promptly, even if symptoms are not immediately apparent. Inform the healthcare professional about the amount of gel ingested and the time of overdose. They may recommend inducing vomiting or administering activated charcoal to prevent further absorption. It is crucial to follow their guidance to ensure the best outcome and prevent potential complications.

In the case of a missed dose of Isotretinoin Gel, it is important to apply the medication as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the missed application. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the treatment or provide specific instructions to ensure the medication's effectiveness. It's crucial to maintain consistency in applying Isotretinoin Gel for optimal results.

To use Isotretinoin Gel, wash your hands, apply a thin layer to the affected skin area once or twice daily, and gently rub it in as directed by your doctor or as indicated on the product instructions.

Here are the conditions and situations when Isotretinoin Gel should not be used:

• Isotretinoin Gel is contraindicated in individuals who are hypersensitive or allergic to isotretinoin or any of its components.
• Avoid using this gel if you have an active skin infection or inflammation in the area to be treated.
• Do not use if you are pregnant or planning to become pregnant, as it can cause severe birth defects.
• Isotretinoin Gel is not recommended for nursing mothers as it may pass into breast milk and harm the baby.
• Should not be used if you have severe liver or kidney disease.
• Avoid using this gel if you have uncontrolled diabetes, as it can increase blood sugar levels.
• Not suitable for individuals with a history of severe depression or other mental health disorders.
• Do not use Isotretinoin Gel if you are taking other medications that may interact with it, such as certain antibiotics, vitamin A derivatives, or certain acne treatments.
• It is contraindicated in individuals with a history of severe gastrointestinal disorders, such as Crohn's disease or ulcerative colitis.
• Avoid using this gel if you have poor wound healing or a history of skin cancer.

The side effects of Isotretinoin Gel may include:

• Skin irritation and redness
• Dryness and peeling of the skin
• Itching or rash at the application site
• Increased sensitivity to sunlight
• Changes in skin color (lightening or darkening)
• Swelling or inflammation of the lips
• Nosebleeds or dry nose
• Temporary hair thinning

Following are the precautions and warnings for Isotretinoin Gel:

• Avoid using Isotretinoin Gel if you are pregnant or planning to become pregnant. It can cause severe birth defects or fetal death. Effective contraception methods must be used during treatment.
• Isotretinoin Gel is not recommended for breastfeeding mothers as it may pass into breast milk and harm the nursing infant.
• Do not donate blood while on Isotretinoin treatment and for at least 1 month after stopping the medication to prevent potential exposure to pregnant blood recipients.
• This medication can cause severe skin reactions and sensitivity to sunlight. Limit sun exposure, use sunscreen, and avoid using sunlamps or tanning beds.
• Isotretinoin may cause changes in mood, including depression, psychosis, and rare cases of suicidal thoughts or behavior. Monitor mood changes and seek medical attention if any unusual symptoms occur.
• Avoid using skin products that can cause irritation, such as harsh soaps, medicated or abrasive cleansers, or skin products with alcohol, spices, or lime.
• Inform your doctor about all medications you are taking, including vitamins, herbal supplements, and prescription/non-prescription drugs, to avoid potential drug interactions.
• Isotretinoin Gel should be used with caution in patients with diabetes, high cholesterol, or a history of depression or mental health disorders. Regular monitoring is necessary.

Following are the drug interactions for Isotretinoin Gel:

• Concomitant use with other topical acne treatments like benzoyl peroxide or tretinoin may increase skin irritation.
• Isotretinoin may reduce the effectiveness of oral vitamin A supplements.
• The gel may interact with certain photosensitizing medications, increasing sensitivity to sunlight.
• Caution with drugs that increase photosensitivity, such as thiazide diuretics, tetracyclines, and sulfonamides.
• It can enhance the effects of oral retinoids, potentially leading to increased side effects.
• Avoid concurrent use with other retinoids to prevent cumulative effects and toxicity.
• Interactions with herbal supplements like St. John's Wort may increase the risk of side effects.

Following are the food interactions for Isotretinoin Gel:

• Avoid excessive Vitamin A intake, as Isotretinoin is a derivative of Vitamin A, and excessive amounts can lead to hypervitaminosis A.
• High-fat meals can increase the absorption of Isotretinoin, potentially leading to higher blood levels of the drug.
• Dairy products like milk, cheese, and yogurt may interfere with the absorption of Isotretinoin, reducing its effectiveness.
• Grapefruit and grapefruit juice should be avoided as they can increase the drug levels in the blood, leading to potential toxicity.
• Green leafy vegetables and colorful fruits rich in antioxidants may help reduce the side effects of Isotretinoin on the skin.
• Avoid spicy and oily foods as they may aggravate skin sensitivity and increase the chances of skin irritation.
• Alcohol consumption is generally not recommended as it can dehydrate the skin, making it more susceptible to dryness and irritation.

Isotretinoin Gel should be stored in a secure location, away from direct sunlight, moisture, and extreme temperatures. Keep the gel in its original container, tightly sealed, to maintain its integrity and prevent contamination. Ensure the storage area is cool and dry, avoiding places like bathrooms or kitchens where humidity can affect the medication. Always check the expiration date before use and never use the gel beyond its expiry. When disposing of Isotretinoin Gel, do not flush it down the toilet or pour it into any water source. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for safe disposal methods. Keep the gel out of children's reach to prevent accidental exposure.

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Following are the quick tips for Isotretinoin Gel:

• Wash your hands before and after applying the gel to maintain hygiene.
• Apply a thin layer of gel to the affected areas as directed by your dermatologist.
• Avoid applying the gel to sensitive areas like the eyes, mouth, and corners of the nose.
• Use a mild, non-medicated moisturizer if your skin becomes too dry during treatment.
• Protect your skin from sunlight and UV rays; use sunscreen and wear protective clothing.
• Do not wax or undergo laser treatments while using the gel, as it can cause skin irritation.
• Inform your doctor about all medications you're taking to ensure safe usage.