Coversam (8/10mg) 10 Tablets

Amlodipine 10mg and Perindopril 8mg work synergistically in this combination tablet to treat hypertension. Amlodipine, a calcium channel blocker, acts by inhibiting the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. This inhibition leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, exerts its effect by inhibiting ACE, which is responsible for the conversion of angiotensin I to angiotensin II. By blocking this conversion, Perindopril decreases angiotensin II levels, resulting in reduced vasoconstriction, lowered aldosterone secretion, and decreased blood pressure. Together, these mechanisms contribute to the effective management of hypertension by lowering blood pressure and reducing the risk of associated cardiovascular complications.

Amlodipine 10mg, Perindopril 8mg

Calcium channel blocker, ACE inhibitor.

Tablet

The following are the uses of Amlodipine 10mg, Perindopril 8mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used for reducing strain on the heart in patients with coronary artery disease
• Used for managing angina (chest pain)
• Used to improve blood flow and oxygen supply to the heart
• Used to prevent and manage heart attacks and strokes
• Used to reduce the risk of heart-related complications
• Used for controlling symptoms like shortness of breath and fatigue
• Used for long-term management of cardiovascular conditions

To be used as per doctor's prescription

In the case of an overdose of Amlodipine 10mg and Perindopril 8mg tablets, symptoms may include severe dizziness, lightheadedness, and a rapid or pounding heartbeat. The affected individual may experience excessive sweating, nausea, and a sudden drop in blood pressure, leading to fainting or even loss of consciousness. It is important to recognize these signs and seek medical assistance promptly to prevent potential complications. Immediate treatment may involve supportive care and close monitoring of vital signs to ensure the patient's stability.

In the case of a missed dose of Amlodipine 10mg, it is generally recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed one. For Perindopril 8mg, if you miss a dose, take it as soon as you remember, but avoid taking two doses close together to compensate for the missed one. It's important to maintain a consistent medication schedule, so try to take your medication at the same time each day. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track.

To take the Amlodipine 10mg and Perindopril 8mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider.

Here are the conditions or situations when Amlodipine 10mg and Perindopril 8mg tablets should not be taken:

• Should not be used in individuals with a known allergy to Amlodipine, Perindopril, or any of the tablet's components.
• Contraindicated in patients with a history of angioedema (swelling under the skin) caused by ACE (angiotensin-converting enzyme) inhibitors.
• Not suitable for individuals with severe liver disease or impaired liver function.
• Should not be used in pregnant or breastfeeding women.
• Contraindicated in patients with aortic valve stenosis (narrowing of the aortic valve in the heart).
• Not recommended for individuals with hypotension (very low blood pressure).
• Avoid in patients with severe renal impairment or those on dialysis.
• Should not be used in patients with hypertrophic cardiomyopathy (thickened heart muscle).

The side effects of Amlodipine 10mg, Perindopril 8mg Tablet may include:

• Dizziness or lightheadedness
• Headache
• Fatigue or weakness
• Swelling of ankles and feet (peripheral edema)
• Skin rash or itching
• Nausea and vomiting
• Cough
• Changes in heart rate (slow or rapid heartbeat)

Following are the precautions and warnings for Amlodipine 10mg, Perindopril 8mg Tablet:

• This medication should be used with caution in patients with liver disease, as it can affect liver function. Close monitoring of liver enzymes is necessary.
• Patients with a history of angioedema should exercise caution, as ACE inhibitors like Perindopril can cause swelling of the face, lips, tongue, or throat. Discontinue use if such symptoms occur.
• Amlodipine may cause dizziness and lightheadedness, especially when standing up from a sitting or lying position. Elderly patients should be cautious to avoid falls.
• Perindopril may cause a decrease in white blood cell count, which can increase the risk of infections. Regular blood tests may be required to monitor this.
• Diabetic patients should be aware that Perindopril may cause a small increase in blood sugar levels. Regular monitoring of blood glucose is recommended.
• Patients with a history of heart disease, aortic stenosis, or hypertrophic cardiomyopathy should use this medication with caution and under medical supervision.
• Avoid using this medication during pregnancy or breastfeeding unless the potential benefits outweigh the risks, as it can have adverse effects on the fetus and infant.
• Inform your doctor about all medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Amlodipine 10mg, Perindopril 8mg Tablet:

• Amlodipine may enhance the blood pressure-lowering effects of other antihypertensive medications, including beta-blockers, ACE inhibitors, and diuretics.
• The combination with certain antibiotics like rifampicin can reduce the effectiveness of amlodipine.
• Perindopril may increase the risk of hyperkalemia when used with potassium-sparing diuretics or potassium supplements.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may decrease the antihypertensive effect of perindopril.
• Lithium levels may be increased when used with perindopril, leading to potential lithium toxicity.
• The use of perindopril with other angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) is not recommended due to increased risk of adverse effects.
• Grapefruit juice may increase the blood levels of amlodipine, potentially leading to increased side effects.
• Concomitant use with CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase amlodipine concentrations in the body.

Following are the food interactions for Amlodipine 10mg and Perindopril 8mg Tablet:

• Avoid consuming large amounts of grapefruits or grapefruit juice as it can increase the blood levels of Amlodipine, leading to potential side effects.
• Alcohol consumption should be limited as it may increase the risk of dizziness and lightheadedness, especially when starting the medication.
• Salt substitutes containing potassium should be used cautiously as Perindopril can increase potassium levels in the body.
• Avoid high-sodium foods as Perindopril is used to reduce blood pressure, and excess sodium can counteract its effects.
• Avoid potassium-rich foods like bananas, oranges, and spinach if you have kidney problems, as Perindopril can affect potassium levels.
• Licorice should be avoided as it can decrease the effectiveness of Perindopril by reducing its absorption.
• Follow a healthy diet low in salt and rich in fruits, vegetables, and whole grains to support blood pressure management.
• Consult your doctor or pharmacist for personalized dietary advice based on your medical history and medication regimen.

Amlodipine 10mg, Perindopril 8mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from excessive heat and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and effectiveness. It is crucial to ensure that the medication is stored away from children and pets to prevent accidental ingestion. Do not use the tablets if the packaging shows signs of tampering or if the expiration date has passed. When disposing of unused or expired tablets, do not throw them into the trash or flush them down the toilet; instead, consult your pharmacist or local waste management guidelines for safe disposal practices to protect the environment.

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Following are the quick tips for Amlodipine 10mg and Perindopril 8mg Tablet:

• Consult your doctor for the right dosage based on your medical condition.
• Take the tablet as a whole with a glass of water, preferably at the same time daily.
• Do not crush, chew, or break the tablet.
• Maintain a consistent medication schedule for better effectiveness.
• Inform your doctor about all medications you are taking to avoid interactions.
• Store the tablets in a cool, dry place, away from direct sunlight.
• If you experience dizziness, avoid driving or operating heavy machinery.