Coversyl Plus (4/1.25mg) 30 Tablets

Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, effectively lowers blood pressure by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This inhibition leads to reduced formation of angiotensin II, resulting in vasodilation and decreased aldosterone secretion, which in turn lowers blood pressure. Indapamide, a thiazide-like diuretic, works by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidneys. This action promotes the excretion of sodium and water, reducing blood volume and subsequently lowering blood pressure. The combination of perindopril 4mg and indapamide 1.25mg in a single tablet provides a synergistic effect, enhancing the antihypertensive response by targeting both the renin-angiotensin-aldosterone system and the renal tubular reabsorption of sodium and chloride.

Angiotensin-converting enzyme (ACE) inhibitor, Thiazide diuretic.

Tablet

The following are the uses of Perindopril 4mg, Indapamide 1.25mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to lower blood pressure and reduce strain on the heart
• Used to treat heart failure and improve symptoms like breathlessness
• Used to reduce the risk of heart attack or stroke in high-risk patients
• Used to improve blood flow and prevent blood vessel-related issues
• Used to manage fluid retention and reduce swelling
• Used for patients with a history of cardiovascular disease
• Used as a long-term treatment to maintain cardiovascular health

In the case of an overdose of Perindopril 4mg and Indapamide 1.25mg tablets, individuals may experience symptoms such as severe dizziness, fainting, rapid or slow heartbeat, and changes in blood pressure. If you suspect an overdose, it is crucial to seek medical assistance promptly. Contact a healthcare professional or go to the nearest emergency department for evaluation and treatment. Quick action can help manage potential complications and ensure the best possible outcome.

In the case of a missed dose of Perindopril 4mg and Indapamide 1.25mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication regimen. It's important to maintain consistency in taking your medication as prescribed.

To take the Perindopril 4mg, Indapamide 1.25mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day as directed by your healthcare provider.

Following are the conditions/situations when Perindopril 4mg, Indapamide 1.25mg Tablet should not be taken:

• Should not be used in patients who are allergic to perindopril, indapamide, or other ACE inhibitors and sulfonamide-derived drugs.
• Contraindicated in individuals with a history of angioedema related to previous ACE inhibitor therapy.
• Not recommended for patients with severe renal impairment or those on dialysis.
• Should not be used in patients with severe liver impairment or hepatic cirrhosis.
• Contraindicated during pregnancy, especially during the second and third trimesters.
• Not suitable for individuals with low blood pressure (hypotension).
• Should be avoided in patients with severe aortic or mitral valve stenosis.
• Contraindicated in patients with a history of hereditary angioedema.
• Not recommended for individuals undergoing high-dose desensitization therapy for wasp or bee venom allergy.

The side effects of Perindopril 4mg, Indapamide 1.25mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Cough
• Headache
• Nausea and vomiting
• Diarrhea or constipation
• Skin rash or itching
• Changes in taste sense

Following are the precautions and warnings for Perindopril 4mg, Indapamide 1.25mg Tablet:

• Patients with a known allergy to perindopril, indapamide, or any other ACE inhibitor/diuretic should not take this medication.
• It may cause hypotension (low blood pressure); caution is advised, especially in patients with existing low blood pressure or those who are dehydrated.
• Regular monitoring of kidney function is necessary, particularly in patients with kidney disease or those at risk of renal impairment.
• Potassium levels should be monitored as the medication can cause hyperkalemia (high potassium levels).
• Diabetic patients should be aware that this medication may affect blood sugar levels.
• Elderly patients may be more susceptible to side effects, and dosage adjustments might be required.
• Not recommended for use during pregnancy or breastfeeding without medical advice.
• Patients should be informed about the symptoms of angioedema and advised to seek immediate medical attention if it occurs.

Following are the drug interactions for Perindopril 4mg, Indapamide 1.25mg Tablet:

• Concomitant use with potassium-sparing diuretics, such as spironolactone or amiloride, may increase the risk of hyperkalemia.
• Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or naproxen, may reduce the antihypertensive effects of perindopril and increase the risk of kidney dysfunction.
• Other antihypertensive medications, including beta-blockers and calcium channel blockers, may enhance the blood pressure-lowering effects, increasing the risk of hypotension.
• Lithium levels may be increased when used with perindopril, leading to a higher risk of lithium toxicity.
• Loop diuretics, such as furosemide, may increase the risk of excessive dehydration and electrolyte imbalances when combined with indapamide.
• Antidiabetic drugs, including insulin and oral hypoglycemics, may have an enhanced glucose-lowering effect when used with indapamide, increasing the risk of hypoglycemia.
• Concomitant use with ACE inhibitors, ARBs, or aliskiren in patients with diabetes or renal impairment may further increase the risk of kidney dysfunction and hyperkalemia.

Following are the food interactions for Perindopril 4mg, Indapamide 1.25mg Tablet:

• Avoid consuming foods high in potassium like bananas, oranges, and spinach as this medication can increase potassium levels in the blood.
• Salt substitutes or reduced-sodium products are recommended as Indapamide can lead to increased sodium excretion.
• Limit alcohol consumption as it may increase the risk of dizziness and lightheadedness, especially when combined with Perindopril's blood pressure-lowering effect.
• Grapefruit and grapefruit juice should be consumed in moderation as they may interact with the medication, affecting its metabolism.
• Maintain a consistent fluid intake, as Indapamide is a diuretic and may cause increased urination.
• Avoid potassium supplements unless prescribed by a doctor, as this medication can affect potassium levels.
• A balanced diet low in sodium is advisable to support the medication's effectiveness in managing blood pressure.
• No significant food interactions are known to affect the absorption of Perindopril and Indapamide, but consult your doctor for personalized advice.

Perindopril 4mg, Indapamide 1.25mg Tablets should be stored in a secure and dry location, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing them in bathrooms or areas exposed to heat, as temperature fluctuations can impact their effectiveness. When disposing of unused or expired tablets, do not flush them or pour them down the drain. Consult your pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety. Always keep medications away from children to prevent accidental consumption.

Following are the quick tips for Perindopril 4mg, Indapamide 1.25mg Tablet:

• Always take the tablet as directed by your doctor; do not alter the dosage.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole with a full glass of water, preferably in the morning before breakfast.
• Avoid crushing, chewing, or breaking the tablet, as it may affect its effectiveness.
• If you experience mild dizziness, it may help to rise slowly from a sitting or lying position.
• Inform your doctor about all your medications to avoid potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.