Creato-SR (35mg) 20 Tablets

Trimetazidine dihydrochloride's primary mechanism of action is related to its ability to enhance cellular metabolism by inhibiting the beta-oxidation of fatty acids. It selectively blocks fatty acid oxidation by inhibiting 3-ketoacyl coenzyme A thiolase, an enzyme involved in the last step of fatty acid oxidation. By shifting cellular metabolism from fatty acid utilization to glucose utilization, trimetazidine promotes more efficient ATP production through glycolysis. This is particularly important in tissues like the heart and brain, where maintaining a constant energy supply is crucial. Trimetazidine helps protect cells against ischemic conditions by ensuring a steady energy source, thereby improving cellular function and reducing the risk of cell damage during periods of reduced oxygen availability.

Anti-ischemic agent

Tablet

The following are the uses of Trimetazidine Dihydrochloride 35mg Tablet:

• Used for treating chest pain caused by reduced blood flow to the heart, known as angina.
• Used to manage symptoms of angina when other treatments are not effective.
• Used to improve heart function and reduce symptoms in patients with heart failure.
• Used to enhance exercise capacity in patients with certain heart conditions.
• Used to reduce the frequency and duration of angina episodes.
• Used as an add-on therapy to standard angina treatments.
• Used to support cardiac rehabilitation programs.

Follow these dosage instructions:

• Take as per doctor's Prescription.
• Take the tablet whole with a glass of water, do not crush or chew it.
• It is recommended to take this medication with meals only.

In the case of an overdose of Trimetazidine Dihydrochloride 35mg Tablets, it is important to seek medical assistance promptly. Symptoms of an overdose may include severe dizziness, fainting, and a significant drop in blood pressure. If you or someone you know has taken an excessive amount of this medication, contact a healthcare professional or go to the nearest emergency room. Quick action can help prevent potential complications and ensure appropriate treatment is provided.

In the case of a missed dose of Trimetazidine Dihydrochloride 35mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, consult your healthcare professional for advice on how to proceed, as they may recommend adjusting your dosing schedule to ensure optimal treatment.

To take Trimetazidine Dihydrochloride 35mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional, without crushing or chewing the tablet.

Here are the situations when Trimetazidine Dihydrochloride 35mg Tablet should not be used:

• Should not be used in patients with a known allergy or hypersensitivity to Trimetazidine or any of its inactive ingredients.
• Contraindicated in patients with severe liver impairment or severe kidney disease.
• Not recommended for individuals with heart failure or low blood pressure (hypotension).
• Should not be used during pregnancy or breastfeeding.
• Not suitable for children and adolescents under 18 years of age.
• Avoid in patients with a history of muscle disorders or muscle weakness.
• Contraindicated in patients with severe metabolic disorders, such as severe lactic acidosis.
• Should not be used in patients with a rare genetic problem of galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency.

The side effects of Trimetazidine Dihydrochloride 35mg Tablet may include:

• Gastrointestinal issues such as nausea, vomiting, and abdominal pain.
• Headaches and dizziness.
• Fatigue and weakness.
• Skin rashes or itching.
• Insomnia or sleep disturbances.
• Dry mouth.
• In rare cases, it may cause palpitations or irregular heartbeats.

Following are the precautions and warnings for Trimetazidine Dihydrochloride 35mg Tablet:

• Do not use if you are allergic to Trimetazidine or any other similar medications.
• This medication should be used with caution in patients with severe kidney or liver disease, as it may require dosage adjustments.
• Patients with a history of heart problems, such as heart block or heart failure, should be closely monitored while taking this medicine.
• Trimetazidine may cause dizziness or blurred vision, so avoid driving or operating heavy machinery until you know how the medication affects you.
• Inform your doctor if you have a history of Parkinson's disease, as this medicine might worsen the symptoms.
• It is important to maintain a balanced diet and not rely solely on this medication for the treatment of angina.
• Elderly patients may be more sensitive to the side effects, hence close monitoring is advised.
• Always inform your doctor about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Trimetazidine Dihydrochloride 35mg Tablet:

• Avoid combining with beta-blockers, as it may decrease the effectiveness of both medications.
• Concomitant use with calcium channel blockers can increase the risk of hypotension.
• Trimetazidine may interact with antiarrhythmic drugs, affecting heart rate and rhythm.
• It can enhance the effects of antihypertensive medications, leading to excessive blood pressure drop.
• Combining with nitrates can result in additive hypotensive effects.
• Use with statins may increase the risk of muscle-related side effects.
• Trimetazidine may influence the metabolism of certain drugs metabolized by CYP enzymes.

Following are the food interactions for Trimetazidine Dihydrochloride 35mg Tablet:

• Avoid consuming large amounts of grapefruit or grapefruit juice as it can interfere with the medication's metabolism, leading to increased drug levels in the body.
• Alcohol consumption should be limited or avoided as it may exacerbate side effects such as dizziness and fatigue.
• Caffeinated beverages like coffee and energy drinks should be consumed in moderation as they may interact with the medication's cardiovascular effects.
• Avoid high-fat meals as they can delay the absorption of Trimetazidine, affecting its effectiveness.
• Avoid excessive salt intake, as Trimetazidine is often prescribed for cardiovascular conditions, and a high-sodium diet may counteract its therapeutic benefits.
• Maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall health while taking this medication.
• Stay hydrated by drinking adequate water, especially if experiencing any gastrointestinal side effects.
• Consult a healthcare professional for personalized dietary advice, especially if you have specific dietary restrictions or medical conditions.

Trimetazidine Dihydrochloride 35mg Tablets should be stored in a secure and dry location, away from direct sunlight and moisture. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity. Avoid exposing the medication to extreme temperatures, such as in the bathroom or near heat sources, as this can impact its effectiveness. Always check the expiration date before using any medication, and properly dispose of any unused or expired tablets. Do not flush them or pour them down the drain; instead, consult a pharmacist for guidance on safe disposal methods. Keep all medications securely stored and out of the reach of children to prevent accidental consumption.

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Following are the quick tips for Trimetazidine Dihydrochloride 35mg Tablet:

• Consult a doctor for proper dosage and duration based on your medical condition.
• Swallow the tablet whole, do not crush or chew.
• Take it with a full glass of water, preferably with or after meals.
• Avoid cutting back or stopping the medication without consulting your doctor.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your health and report any unusual symptoms to your healthcare provider.