Curitol (200mg) 100ml,1 Vial Infusion

Ofloxacin 200mg, a synthetic chemotherapeutic antibiotic, exerts its bactericidal effect by targeting two essential bacterial enzymes DNA gyrase and topoisomerase IV. By binding to these enzymes, Ofloxacin inhibits DNA replication and transcription, thereby preventing the bacteria from multiplying. This mechanism is highly effective against a broad spectrum of gram-positive and gram-negative bacteria, making Ofloxacin a potent antimicrobial agent. The drug disrupts the structure of bacterial DNA, leading to cellular dysfunction and ultimately, bacterial cell death.

Quinolone antibiotic.

Infusion

The following are the uses of Ofloxacin 200mg Infusion:

• Used for treating severe bacterial infections that require rapid action, such as septicemia (blood poisoning).
• Used for bacterial infections in patients who cannot take oral medications.
• Used for serious lung infections like pneumonia, especially in hospitalized patients.
• Used for complicated urinary tract infections that have spread to the kidneys.
• Used for skin and soft tissue infections, ensuring deep penetration to eradicate bacteria.
• Used for bone and joint infections, as it can reach these areas effectively.
• Used for intra-abdominal infections, providing broad-spectrum coverage.
• Used for certain sexually transmitted infections caused by bacteria.

In the case of an overdose of Ofloxacin 200mg Infusion, several symptoms may occur, including nausea, vomiting, dizziness, and headaches. It is important to recognize the signs of an overdose, which can range from mild gastrointestinal discomfort to more severe neurological effects. If you suspect an overdose, seek medical advice promptly. Timely intervention can help manage the symptoms and prevent potential complications associated with excessive Ofloxacin intake.

In the case of a missed dose of Ofloxacin 200mg Infusion, it is important to take action promptly. If you remember within a few hours of the missed dose, administer the medication as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare professional if you have any concerns or if you miss multiple doses.

To administer Ofloxacin 200mg Infusion, prepare the infusion solution as directed, ensuring proper dilution, and administer the entire contents intravenously over a period of 60 minutes, preferably at a constant rate using an infusion pump.

Here are the situations when Ofloxacin 200mg Infusion should not be used:

• Should not be used in patients with a known allergy to Ofloxacin or other quinolone antibiotics.
• Contraindicated in patients with a history of myasthenia gravis as it can worsen muscle weakness.
• Not suitable for individuals with a history of tendon disorders or tendon rupture related to previous quinolone therapy.
• Should be avoided in patients with epilepsy or other seizure disorders, as it may lower the seizure threshold.
• Contraindicated in patients with prolonged QT intervals or known heart rhythm disorders.
• Should not be used in individuals with severe liver disease or reduced liver function.
• Not recommended for children, adolescents, pregnant women, and breastfeeding mothers.
• Should be discontinued if severe diarrhea, abdominal pain, or signs of pseudomembranous colitis occur.
• Avoid exposure to sunlight or UV rays during treatment due to increased photosensitivity.
• Discontinue use if signs of serious skin reactions or rashes appear.

The side effects of Ofloxacin 200mg Infusion may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Skin rash or itching
• Sensitivity to sunlight (photosensitivity)
• Central Nervous System (CNS) effects like confusion, insomnia, or rarely, seizures
• Joint and muscle pain

Following are the precautions and warnings for Ofloxacin 200mg Infusion:

• Not recommended for individuals with a known hypersensitivity or allergy to Ofloxacin or other quinolone antibiotics.
• Caution is advised in patients with a history of seizures or epilepsy, as Ofloxacin may lower the seizure threshold.
• Should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• Avoid excessive exposure to sunlight or UV rays as Ofloxacin can increase skin sensitivity.
• Not suitable for children, pregnant or breastfeeding women, and elderly patients without medical advice.
• Patients may experience dizziness or lightheadedness; avoid activities that require alertness until the effects are known.
• Discontinue use and seek medical attention if severe side effects such as tendon pain, central nervous system effects, or allergic reactions occur.

Following are the drug interactions for Ofloxacin 200mg Infusion:

• Theophylline absorption may be reduced, leading to lower blood levels and potential therapeutic failure.
• Probenecid can decrease the renal tubular secretion of ofloxacin, increasing its blood levels.
• Concomitant use with other drugs that prolong QT interval (e.g., certain antiarrhythmics, antipsychotics) may increase the risk of cardiac arrhythmias.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of central nervous system stimulation and seizures.
• Antacids containing magnesium or aluminum can reduce the absorption of ofloxacin, decreasing its effectiveness.
• Sucralfate can reduce the absorption of ofloxacin, leading to lower blood levels.
• Ofloxacin may enhance the effects of warfarin and other oral anticoagulants, requiring close monitoring of coagulation parameters.

Following are the food interactions for Ofloxacin 200mg Infusion:

• Avoid caffeine and energy drinks as they may enhance the side effects of Ofloxacin, leading to increased nervousness, anxiety, and insomnia.
• Limit dairy products like milk, cheese, and yogurt, as they can decrease the absorption of Ofloxacin, reducing its effectiveness.
• Avoid high-fat meals as they may delay the absorption of Ofloxacin, potentially affecting its therapeutic efficacy.
• Alcohol should be avoided as it can increase the risk of Ofloxacin's side effects, particularly central nervous system effects like dizziness and lightheadedness.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Ofloxacin, leading to increased drug levels and potential side effects.
• Consuming iron-rich foods like red meat, beans, and spinach close to the time of Ofloxacin administration may decrease its absorption. It's best to separate them by a few hours.
• Vitamin and mineral supplements containing zinc, magnesium, and iron can interfere with Ofloxacin absorption and should be taken at different times.
• Ensure adequate hydration by drinking plenty of fluids, especially water, to reduce the risk of Ofloxacin-related side effects on the kidneys.

Ofloxacin 200mg Infusion should be stored in a secure and controlled environment, preferably in a dedicated storage area with restricted access. Maintain a cool and dry storage location, ideally at room temperature (20-25°C), to preserve the integrity of the medication. Protect the infusion from direct sunlight, as exposure to light can degrade its potency. Ensure the packaging remains intact and tightly sealed to prevent contamination and maintain sterility. It is crucial to adhere to proper waste management practices by disposing of any unused or expired Ofloxacin Infusion according to local regulations and guidelines. Do not dispose of it in regular household waste or pour it down the drain; instead, contact healthcare professionals or pharmacists for guidance on safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption, as it is intended for professional medical use only.

Following are the quick tips for Ofloxacin 200mg Infusion:

• Administer the infusion under medical supervision for best results.
• Ensure the infusion is prepared and administered by trained medical staff.
• Check the infusion for any discoloration or particles before use.
• Use a sterile, non-pyrogenic, low-adsorption intravenous infusion set for administration.
• Infuse over a period of 60 minutes to minimize side effects.
• Do not mix with other medications in the same infusion; use a separate line if necessary.
• Store the infusion at room temperature, away from direct sunlight and moisture.