Cutibet G (0.05/0.1%) 15g Cream

Hydrochlorothiazide and telmisartan are both components of a combination medication used to treat hypertension (high blood pressure). Hydrochlorothiazide is a diuretic (sometimes called a 'water pill') that works by inhibiting the reabsorption of sodium and chloride in the distal convoluted tubule of the kidney, leading to increased excretion of water and sodium, which helps lower blood pressure. Telmisartan, on the other hand, is an angiotensin II receptor blocker (ARB). It blocks the action of angiotensin II, a hormone that normally causes blood vessels to narrow. By blocking this effect, telmisartan causes blood vessels to relax and widen, thereby reducing blood pressure. This dual mechanism of action helps to effectively control blood pressure by different pathways, making it a useful combination for managing hypertension.

Betamethasone, Gentamycin

Angiotensin Receptor Blocker, Diuretic.

cream

The following are the uses of Hydrochlorothiazide, Telmisartan Cream:

• Used for controlling high blood pressure
• Used to treat hypertension
• Used to reduce the risk of cardiovascular events in patients with high blood pressure
• Used to promote blood flow and lower blood pressure
• Used in the treatment of heart failure, often alongside other medications
• Used to reduce fluid retention and swelling
• Used for managing diabetes-related kidney disease
• Used to prevent kidney damage and delay the progression of kidney disease

In the case of an overdose of Hydrochlorothiazide, symptoms may include excessive urination, electrolyte imbalances, and dehydration. Medical attention should be sought to manage symptoms. For Telmisartan Cream, an overdose is unlikely to cause severe symptoms, but it may lead to increased blood pressure and dizziness. It is important to contact a healthcare professional for guidance and to determine the best course of action in either case.

In the case of a missed dose of Hydrochlorothiazide, it is generally recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Telmisartan Cream, if you forget to apply it, apply it as soon as you remember, but if it's close to the time for your next application, skip the missed application and continue with your regular application schedule. Do not double the dose to make up for a missed one.

To apply Hydrochlorothiazide, Telmisartan Cream, clean and dry the affected area, then gently massage a thin layer of the cream onto the skin once daily, following the instructions provided by your healthcare professional or as directed on the product packaging.

Following are the conditions/situations when Hydrochlorothiazide and Telmisartan Cream should not be used:

• Should not be used in individuals with a known allergy to Hydrochlorothiazide, Telmisartan, or any of the cream's components.
• Contraindicated in patients with a history of angioedema or allergic reactions to other blood pressure medications.
• Not recommended for individuals with severe kidney disease or impaired kidney function.
• Should not be used in patients with severe liver disease or biliary obstruction.
• Contraindicated during pregnancy and breastfeeding.
• Avoid using the cream if you have diabetes or impaired glucose tolerance without proper medical supervision.
• Not suitable for individuals with low blood sodium levels (hyponatremia) or low blood potassium levels (hypokalemia).
• Should not be used in patients with gout or a history of elevated uric acid levels.

The side effects may include:

• Increased urination
• Dizziness or lightheadedness
• Fatigue and weakness
• Nausea and vomiting
• Electrolyte imbalances (low potassium, sodium, or magnesium levels)
• Skin sensitivity to sunlight
• Headaches
• Muscle cramps
• Skin irritation or rash at the application site
• Itching or redness
• Mild dizziness
• Nasal congestion
• Back pain
• Diarrhea
• Upper respiratory tract infections

Following are the precautions and warnings for Hydrochlorothiazide, Telmisartan Cream:

• Avoid using this medication if you are allergic to any of its ingredients, including hydrochlorothiazide and telmisartan.
• Patients with a history of kidney or liver disease should use this medication with caution and under medical supervision as it may affect these organs.
• Inform your doctor if you have diabetes, as hydrochlorothiazide can alter blood sugar levels. Regular monitoring is necessary.
• Be cautious if you have a history of angioedema or are taking medications that may cause angioedema, as telmisartan may increase the risk.
• Do not drive or operate heavy machinery if you experience dizziness or lightheadedness as a side effect.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as it may have potential risks for the fetus and infant.
• Keep this medication out of reach of children and pets. Store it at room temperature, away from direct sunlight and moisture.

Following are the drug interactions for Hydrochlorothiazide and Telmisartan Cream:

• Hydrochlorothiazide can increase the risk of lithium toxicity when used with lithium, and close monitoring of lithium levels is required.
• The antihypertensive effect of Telmisartan may be reduced when used with NSAIDs (e.g., ibuprofen, naproxen), possibly leading to decreased blood pressure control.
• Potassium-sparing diuretics (e.g., spironolactone, eplerenone) and potassium supplements may increase the risk of hyperkalemia when used with Telmisartan. Regular monitoring of potassium levels is advised.
• The blood pressure-lowering effect of Hydrochlorothiazide may be reduced by corticosteroids, possibly leading to decreased efficacy.
• Telmisartan may enhance the blood glucose-lowering effect, potentially increasing the risk of hypoglycemia.
• The antihypertensive effect of Hydrochlorothiazide can be reduced by estrogens and oral contraceptives, requiring careful monitoring of blood pressure.
• Telmisartan may increase serum digoxin levels, so monitoring for digoxin toxicity is necessary when these drugs are used together.

Following are the food interactions for Hydrochlorothiazide and Telmisartan Cream:

• Grapefruit and grapefruit juice should be avoided as they may decrease the breakdown of Hydrochlorothiazide, leading to increased drug levels in the body and potentially causing electrolyte imbalances and other side effects.
• Alcohol consumption may increase the blood pressure-lowering effect of Telmisartan, and excessive alcohol intake can also reduce the effectiveness of Hydrochlorothiazide.
• Salt substitutes containing potassium should be used with caution as Hydrochlorothiazide can increase potassium levels, and excessive potassium intake may lead to hyperkalemia.
• Limit the consumption of foods high in potassium like bananas, oranges, and tomatoes, as Hydrochlorothiazide can affect potassium levels.
• Avoid or limit the use of licorice, especially if you have high blood pressure, as it may reduce the effectiveness of Hydrochlorothiazide.
• Avoid excessive consumption of dairy products, as Hydrochlorothiazide may cause calcium loss, and Telmisartan can increase calcium levels.
• Be cautious with salty foods, as Hydrochlorothiazide is a diuretic and can increase the loss of sodium.
• Avoid or limit caffeine intake, as it may reduce the effectiveness of Telmisartan in lowering blood pressure.

Hydrochlorothiazide and Telmisartan Cream should be stored in a secure and dry location, preferably in its original container, away from direct sunlight, moisture, and heat sources like ovens or radiators. Maintaining a consistent room temperature is crucial for the medication's stability. When disposing of Hydrochlorothiazide and Telmisartan Cream, avoid flushing it down the toilet or pouring it into drains. Instead, consult your pharmacist or healthcare provider for safe disposal methods to prevent environmental contamination. Always keep medications out of children's reach to prevent accidental ingestion. Proper storage and disposal practices ensure the safety and effectiveness of the medication while minimizing potential risks.

Following are the quick tips for Hydrochlorothiazide and Telmisartan Cream:

• Consult your doctor before use, especially if you have kidney or liver problems.
• Take the medication as directed, usually once daily, to maintain effectiveness.
• Hydrochlorothiazide may cause increased sensitivity to the sun; limit sun exposure and use sunscreen.
• Avoid getting Telmisartan Cream in your eyes; if contact occurs, rinse thoroughly with water.
• Do not stop taking Hydrochlorothiazide without consulting your doctor to prevent potential complications.
• Store Hydrochlorothiazide at room temperature, away from moisture and heat.
• Telmisartan Cream should be applied as a thin layer to the affected area, as instructed by your healthcare provider.